Catalog No.
PHE64501
Species reactivity
Human, Mouse
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human CDK8 (Glu21-Asp392).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
Mediator complex subunit CDK8, Mediator of RNA polymerase II transcription subunit CDK8, Protein kinase K35, Cyclin-dependent kinase 8, CDK8, Cell division protein kinase 8
Purification
Purified by antigen affinity column.
Accession
P49336
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Synthesis and Structure-Activity Relationships of Novel Benzofuran Derivatives with Osteoblast Differentiation-Promoting Activity., PMID:39805602
Inhibition of CDK8/19 Mediator kinase potentiates HER2-targeting drugs and bypasses resistance to these agents in vitro and in vivo., PMID:35914167
Recombinase-mediated cassette exchange-based screening of a CRISPR/Cas9 library for enhanced recombinant protein production in human embryonic kidney cells: Improving resistance to hyperosmotic stress., PMID:35398513
The Inhibition of CDK8/19 Mediator Kinases Prevents the Development of Resistance to EGFR-Targeting Drugs., PMID:33445730
Selective and Potent CDK8/19 Inhibitors Enhance NK-Cell Activity and Promote Tumor Surveillance., PMID:32024684
Mitochondrial translocation of cyclin C stimulates intrinsic apoptosis through Bax recruitment., PMID:31385392
The microRNA-141-3p/ CDK8 pathway regulates the chemosensitivity of breast cancer cells to trastuzumab., PMID:31087707
The Cdk8/19-cyclin C transcription regulator functions in genome replication through metazoan Sld7., PMID:30695077
Cdk8 deletion in the Apc(Min) murine tumour model represses EZH2 activity and accelerates tumourigenesis., PMID:26235356
Mutated K-ras activates CDK8 to stimulate the epithelial-to-mesenchymal transition in pancreatic cancer in part via the Wnt/β-catenin signaling pathway., PMID:25305448
Regulation of renal fibrosis by Smad3 Thr388 phosphorylation., PMID:24485922
IFNα signaling through PKC-θ is essential for antitumor NK cell function., PMID:25960930
Silibinin suppresses growth of human colorectal carcinoma SW480 cells in culture and xenograft through down-regulation of beta-catenin-dependent signaling., PMID:20454513
A homologue of Cdk8 is required for spore cell differentiation in Dictyostelium., PMID:15196949
Walleye dermal sarcoma virus cyclin interacts with components of the mediator complex and the RNA polymerase II holoenzyme., PMID:12134008
Molecular cloning and characterisation of p15(CDK-BP), a novel CDK-binding protein., PMID:12007796
Characterization of mediator complexes from HeLa cell nuclear extract., PMID:11416138
Characterization of a novel cdk1-related kinase., PMID:10447673
Functional cooperation of cyclin C and c-Myc in mediating homotypic cell adhesion via very late antigen-4 activation and vascular cell adhesion molecule-1 induction., PMID:9845536
A human RNA polymerase II complex containing factors that modify chromatin structure., PMID:9710619
Cell cycle phase specificity of putative cyclin-dependent kinase variants in synchronized alfalfa cells., PMID:9061953
Alternatively spliced cyclin C mRNA is widely expressed, cell cycle regulated, and encodes a truncated cyclin box., PMID:8761291
The cyclin C/Cdk8 kinase., PMID:9552396
For research use only. Not for human or drug use.
