Catalog No.
PHD95801
Species reactivity
Human, Rat
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human FMO3 (Lys280-Thr532).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
Dimethylaniline oxidase 3, FMO form 2, Dimethylaniline monooxygenase [N-oxide-forming] 3, FMO3, FMO II, FMO 3, Trimethylamine monooxygenase, Hepatic flavin-containing monooxygenase 3
Purification
Purified by antigen affinity column.
Accession
P31513
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Hepatic Flavin-Containing Monooxygenase 3 Enzyme Suppressed by Type 1 Allergy-Produced Nitric Oxide., PMID:28760731
Drug oxygenation activities mediated by liver microsomal flavin-containing monooxygenases 1 and 3 in humans, monkeys, rats, and minipigs., PMID:24821112
Pharmacogenomics variation in drug metabolizing enzymes and transporters in relation to docetaxel toxicity in Lebanese breast cancer patients: paving the way for OMICs in low and middle income countries., PMID:23758476
Identification of human cytochrome P450 isoforms and esterases involved in the metabolism of mirabegron, a potent and selective β3-adrenoceptor agonist., PMID:22509825
CYP4F enzymes are responsible for the elimination of fingolimod (FTY720), a novel treatment of relapsing multiple sclerosis., PMID:21045201
In vitro metabolism studies of nomifensine monooxygenation pathways: metabolite identification, reaction phenotyping, and bioactivation mechanism., PMID:20595377
In vitro metabolism and inhibitory effects of pranlukast in human liver microsomes., PMID:19336906
Differential localization of flavin-containing monooxygenase (FMO) isoforms 1, 3, and 4 in rat liver and kidney and evidence for expression of FMO4 in mouse, rat, and human liver and kidney microsomes., PMID:19307449
Purification and characterization of flavin-containing monooxygenase isoform 3 from rat kidney microsomes., PMID:18775983
Identification of the human enzymes involved in the oxidative metabolism of dasatinib: an effective approach for determining metabolite formation kinetics., PMID:18556438
Role of flavin-containing monooxygenase in oxidative metabolism of voriconazole by human liver microsomes., PMID:18362161
Hepatic metabolism of MK-0457, a potent aurora kinase inhibitor: interspecies comparison and role of human cytochrome P450 and flavin-containing monooxygenase., PMID:17537870
Determination of cellular localization of expression of flavin-containing monooxygenase genes in mouse tissues by in situ hybridization., PMID:16719401
Species differential stereoselective oxidation of a methylsulfide metabolite of MK-0767 [(+/-)-5-[(2,4-dioxothiazolidin-5-yl)methyl]-2-methoxy-N-[[(4-trifluoromethyl)phenyl]methyl]benzamide], a peroxisome proliferator-activated receptor dual agonist., PMID:15229170
Unique monooxygenation pattern indicates novel flavin-containing monooxygenase in liver of rainbow trout., PMID:15178073
Identification of metabolic pathways involved in the biotransformation of tolperisone by human microsomal enzymes., PMID:12695352
Human kidney flavin-containing monooxygenases and their potential roles in cysteine s-conjugate metabolism and nephrotoxicity., PMID:12490590
Cloning, sequencing and tissue distribution of rat flavin-containing monooxygenase 4: two different forms are produced by tissue-specific alternative splicing., PMID:12488558
Metabolism of a disulfiram metabolite, S-methyl N,N-diethyldithiocarbamate, by flavin monooxygenase in human renal microsomes., PMID:11159801
In vitro evaluation of the disposition of A novel cysteine protease inhibitor., PMID:11038163
Immunoquantitation of FMO1 in human liver, kidney, and intestine., PMID:10950857
Relative contribution of cytochromes P-450 and flavin-containing monoxygenases to the metabolism of albendazole by human liver microsomes., PMID:10759686
Interspecies comparison and role of human cytochrome P450 and flavin-containing monooxygenase in hepatic metabolism of L-775,606, a potent 5-HT(1D) receptor agonist., PMID:10659950
Roles of FMO and CYP450 in the metabolism in human liver microsomes of S-methyl-N,N-diethyldithiocarbamate, a disulfiram metabolite., PMID:10443982
Identification of cytochrome P450 enzymes involved in the metabolism of zotepine, an antipsychotic drug, in human liver microsomes., PMID:10219963
Expression of two different FMOs in sheep liver., PMID:9492394
Quantitation and kinetic properties of hepatic microsomal and recombinant flavin-containing monooxygenases 3 and 5 from humans., PMID:9305407
Enzymes involved in the bioactivation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in patas monkey lung and liver microsomes., PMID:9276633
Antibodies to a synthetic peptide that react with flavin-containing monooxygenase (HLFMO3) in human hepatic microsomes., PMID:9174980
Biocatalysts in detoxication of drugs of abuse., PMID:9260191
Characterization of the methionine S-oxidase activity of rat liver and kidney microsomes: immunochemical and kinetic evidence for FMO3 being the major catalyst., PMID:8806760
Cerebral metabolism of imipramine and a purified flavin-containing monooxygenase from human brain., PMID:8840349
Further characterization of rat brain flavin-containing monooxygenase. Metabolism of imipramine to its N-oxide., PMID:8630088
Olfactory toxicity of methimazole: dose-response and structure-activity studies and characterization of flavin-containing monooxygenase activity in the Long-Evans rat olfactory mucosa., PMID:7501959
Prochiral sulfides as in vitro probes for multiple forms of the flavin-containing monooxygenase., PMID:7720102
Metabolism of thioridazine by microsomal monooxygenases: relative roles of P450 and flavin-containing monooxygenase., PMID:7645304
Characterization of flavin-containing monooxygenase 5 (FMO5) cloned from human and guinea pig: evidence that the unique catalytic properties of FMO5 are not confined to the rabbit ortholog., PMID:7872795
Characterization of hepatic flavin monooxygenase from the marine teleost turbot (Scophthalmus maximus L.)., PMID:7618340
Characterization of liver flavin-containing monooxygenase of the dogfish shark (Squalus acanthias) and partial purification of liver flavin-containing monooxygenase of the silky shark (Carcharhinus falciformis)., PMID:7881827
Purification and characterization of a pyrrole-2-carboxylate oxygenase from Arthrobacter strain Py1., PMID:8011178
Role of flavin-dependent monooxygenases and cytochrome P450 enzymes in the sulfoxidation of S-methyl N,N-diethylthiolcarbamate., PMID:8274163
An assay of flavin-containing monooxygenase activity with benzydamine N-oxidation., PMID:8109727
Metabolism of the antimammary cancer antiestrogenic agent tamoxifen. II. Flavin-containing monooxygenase-mediated N-oxidation., PMID:8104125
Functional characterization of flavin-containing monooxygenase 1B1 expressed in Saccharomyces cerevisiae and Escherichia coli and analysis of proposed FAD- and membrane-binding domains., PMID:8449936
Purification of macaque liver flavin-containing monooxygenase: a form of the enzyme related immunochemically to an isozyme expressed selectively in adult human liver., PMID:8448176
Immunological characterization of flavin-containing monooxygenases from the liver of rainbow trout (Oncorhynchus mykiss): sexual- and age-dependent differences and the effect of trimethylamine on enzyme regulation., PMID:8427868
Channel catfish liver monooxygenases. Immunological characterization of constitutive cytochromes P450 and the absence of active flavin-containing monooxygenases., PMID:8424815
Cytochrome P-450 3A4 (nifedipine oxidase) is responsible for the C-oxidative metabolism of 1-nitropyrene in human liver microsomal samples., PMID:1423267
Cellular localization of flavin-containing monooxygenase in rabbit lung., PMID:1572320
The flavin-containing monooxygenase in mouse lung: evidence for expression of multiple forms., PMID:1479594
For research use only. Not for human or drug use.
