Catalog No.
PHE25401
Species reactivity
Human
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human CD42d/GP5 (Gln17-Pro242).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
Platelet glycoprotein V, CD42d, GP5, GPV, Glycoprotein 5
Purification
Purified by antigen affinity column.
Accession
P40197
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
CD19 chimeric antigen receptor-T cell therapy in murine immune thrombocytopenia., PMID:40139759
Preventative and therapeutic effects of a novel humanized anti-glycoprotein Ibα fragment of antigen-binding region in a murine model of thrombotic thrombocytopenic purpura., PMID:39956431
A novel antibody against GPIbα inhibits platelet function and thrombosis without increasing bleeding., PMID:39924011
Jararaca GPIb-binding protein causes thrombocytopenia during Bothrops jararaca envenomation., PMID:39738271
The role of protein kinase C and the glycoprotein Ibα cytoplasmic tail in anti-glycoprotein Ibα antibody-induced platelet apoptosis and thrombocytopenia., PMID:39541612
Platelet collagen receptors and their role in modulating platelet adhesion patterns and activation on alternatively processed collagen substrates., PMID:39499978
The effects of complement-independent, autoantibody-induced apoptosis of platelets in immune thrombocytopenia (ITP)., PMID:39271523
Platelet-Type von Willebrand Disease: Complex Pathophysiology and Insights on Novel Therapeutic and Diagnostic Strategies., PMID:39191406
Novel GPIb-independent platelet aggregation induced by botrocetin: implications for diagnosis and antithrombotic therapy., PMID:39147240
Nanobody activator improves sensitivity of the von Willebrand factor activity assay to multimer size., PMID:38704122
GPIbα CAAR T cells function like a Trojan horse to eliminate autoreactive B cells to treat immune thrombocytopenia., PMID:38299614
Genetic Polymorphisms of GP1BA, PEAR1, and PAI-1 may be Associated with Serum sIgE and Blood Eosinophil Levels in Chinese Patients with Allergic Diseases., PMID:38299390
Recombinantly Expressed Tagged SUrface Protein (RETSUP) assay: a new diagnostic system for the detection of antibodies to platelets., PMID:38184205
Anti-GPIb/IX autoantibodies are associated with poor response to dexamethasone combined with rituximab therapy in primary immune thrombocytopenia patients., PMID:37722393
Synergy by Ristocetin and CXCL12 in Human Platelet Activation: Divergent Regulation by Rho/Rho-Kinase and Rac., PMID:37298667
TMIGD1: Emerging functions of a tumor supressor and adhesion receptor., PMID:37087524
[Platelet adhesion mediated by von Willebrand factor in patients with premature coronary artery disease]., PMID:37061861
Serum from half of patients with immune thrombocytopenia trigger macrophage phagocytosis of platelets., PMID:37042934
The association between platelet glycoprotein-specific antibodies and response to short-term high-dose dexamethasone with prednisone maintenance treatment in adult patients with primary immune thrombocytopenia., PMID:36799363
von Willebrand factor neutralizing and non-neutralizing alloantibodies in 213 subjects with type 3 von Willebrand disease enrolled in 3WINTERS-IPS., PMID:36792472
Anti-glycoprotein autoantibodies are related to bleeding severity in children with newly diagnosed ITP and very low platelet counts., PMID:36377718
Bitiscetin-3, a Novel C-Type Lectin-like Protein Cloned from the Venom Gland of the Viper Bitis arietans, Induces Platelet Agglutination and Inhibits Binding of Von Willebrand Factor to Collagen., PMID:35448845
Acute drug-induced immune thrombocytopenia - A work of articaine., PMID:35305268
Fast clearance of platelets in a commonly used mouse model for GPIbα is impeded by an anti-GPIbβ antibody derivative., PMID:35305057
Structure-Based Cyclic Glycoprotein Ibα-Derived Peptides Interfering with von Willebrand Factor-Binding, Affecting Platelet Aggregation under Shear., PMID:35216161
Antiplatelet antibody predicts platelet desialylation and apoptosis in immune thrombocytopenia., PMID:35199503
The impact of aberrant von Willebrand factor-GPIbα interaction on megakaryopoiesis and platelets in humanized type 2B von Willebrand disease model mouse., PMID:35142156
Humanized von Willebrand factor reduces platelet sequestration in ex vivo and in vivo xenotransplant models., PMID:34657336
Anti-glycoprotein antibodies and sequestration pattern of indium-labeled platelets in immune thrombocytopenia., PMID:34654052
Performance characteristics of platelet autoantibody testing for the diagnosis of immune thrombocytopenia using strict clinical criteria., PMID:34109621
In vitro assessment and phase I randomized clinical trial of anfibatide a snake venom derived anti-thrombotic agent targeting human platelet GPIbα., PMID:34083615
Platelet autoantibody specificity and response to rhTPO treatment in patients with primary immune thrombocytopenia., PMID:33993469
Differential regulation of the platelet GPIb-IX complex by anti-GPIbβ antibodies., PMID:33915031
A fibrinolytic snake venom metalloproteinase, mutalysin-II, with antiplatelet activity and targeting capability toward glycoprotein GPIbα and glycoprotein GPVI., PMID:33548391
Influence of long-term proteasome inhibition on platelet responsiveness mediated by bortezomib., PMID:33422688
Novel aptamer to von Willebrand factor A1 domain (TAGX-0004) shows total inhibition of thrombus formation superior to ARC1779 and comparable to caplacizumab., PMID:33131252
Production of fever mediator PGE2 in human monocytes activated with MDP adjuvant is controlled by signaling from MAPK and p300 HAT: Key role of T cell derived factor., PMID:33126082
Targeting shear gradient activated von Willebrand factor by the novel single-chain antibody A1 reduces occlusive thrombus formation in vitro., PMID:33054112
Glycoprotein VI is not a Functional Platelet Receptor for Fibrin Formed in Plasma or Blood., PMID:32492725
"ITP" is not always immune thrombocytopenia., PMID:32419170
Physiological functions of junctional adhesion molecules (JAMs) in tight junctions., PMID:32247783
Red blood cell-derived semaphorin 7A promotes thrombo-inflammation in myocardial ischemia-reperfusion injury through platelet GPIb., PMID:32161256
Mechanisms of anti-GPIbα antibody-induced thrombocytopenia in mice., PMID:32157300
Platelet depletion limits the severity but does not prevent the occurrence of experimental transfusion-related acute lung injury., PMID:32108957
Anti-platelet antibody immunoassays in childhood immune thrombocytopenia: a systematic review., PMID:32080872
A modern reassessment of glycoprotein-specific direct platelet autoantibody testing in immune thrombocytopenia., PMID:31891657
T cell-derived soluble glycoprotein GPIbα mediates PGE2 production in human monocytes activated with the vaccine adjuvant MDP., PMID:31594856
Appropriation of GPIbα from platelet-derived extracellular vesicles supports monocyte recruitment in systemic inflammation., PMID:31467123
A Uniform Shear Assay for Human Platelet and Cell Surface Receptors via Cone-plate Viscometry., PMID:31233025
Is the mysterious platelet receptor GPV an unsuspected major target for platelet autoantibodies?, PMID:31152089
For research use only. Not for human or drug use.
