Catalog No.
PHJ83901
Species reactivity
Human, Mouse, Rat
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human TRPC6 (Met1-Leu192).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
TrpC6, TRP-6, Short transient receptor potential channel 6, Transient receptor protein 6, TRP6, TRPC6
Purification
Purified by antigen affinity column.
Accession
Q9Y210
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Cdc42 Activation in Anti-nephrin Antibody-Induced Nephropathy., PMID:40459930
TRPC6-targeted dexamethasone nanobubbles with ultrasound-guided theranostics for adriamycin-induced nephropathy., PMID:40448086
Distribution of TRPC1, TRPC3, and TRPC6 in the human thyroid., PMID:39740284
Evaluation of immunohistochemical TRPC3 and TRPC6 expression patterns in human endometriosis., PMID:39689787
TRPC6 is ubiquitously present in lymphatic tissues: A study using samples from body donors., PMID:39161881
Immunohistochemical expression of the cation channel TRPC6 in the submandibular and lacrimal gland and in salivary gland tumors., PMID:39098247
Distribution of TRPC3 and TRPC6 in the human exocrine and endocrine pancreas., PMID:38870712
TRPC3 Is Downregulated in Primary Hyperparathyroidism., PMID:38673977
Immunohistochemistry Reveals TRPC Channels in the Human Hearing Organ-A Novel CT-Guided Approach to the Cochlea., PMID:37298241
Familial systemic lupus erythematosus associated with a loss-of-function mutation in TRPC6., PMID:36944475
Neuroprotective Effects of Estrogen Through BDNF-Transient Receptor Potential Channels 6 Signaling Pathway in the Hippocampus in a Rat Model of Perimenopausal Depression., PMID:35875795
Evaluation of the presence of TRPC6 channels in human vessels: A pilot study using immunohistochemistry., PMID:35371476
RAGE and αVβ3-integrin are essential for suPAR signaling in podocytes., PMID:34166766
The ATP-gated P2X1 ion channel contributes to the severity of antibody-mediated Transfusion-Related Acute Lung Injury in mice., PMID:30914724
Potential Arrhythmogenic Role of TRPC Channels and Store-Operated Calcium Entry Mechanism in Mouse Ventricular Myocytes., PMID:30618800
Angiotensin II Type I Receptor Agonistic Autoantibody Induces Podocyte Injury via Activation of the TRPC6- Calcium/Calcineurin Pathway in Pre-Eclampsia., PMID:30380548
Endocardial TRPC-6 Channels Act as Atrial Mechanosensors and Load-Dependent Modulators of Endocardial/Myocardial Cross-Talk., PMID:30062171
Effects of nerve growth factor neutralization on TRP channel expression in laser-captured bladder afferent neurons in mice with spinal cord injury., PMID:29960052
Calcium-Sensing Receptor Stimulation in Cultured Glomerular Podocytes Induces TRPC6-Dependent Calcium Entry and RhoA Activation., PMID:29050010
Cardiovascular Effects of Renal Distal Tubule Deletion of the FGF Receptor 1 Gene., PMID:28993502
Genome-wide association study of cardiotoxicity in the NCCTG N9831 (Alliance) adjuvant trastuzumab trial., PMID:28763429
Differences in TRPC3 and TRPC6 channels assembly in mesenteric vascular smooth muscle cells in essential hypertension., PMID:27861908
Single nucleotide polymorphisms and genotypes of transient receptor potential ion channel and acetylcholine receptor genes from isolated B lymphocytes in myalgic encephalomyelitis/chronic fatigue syndrome patients., PMID:27834303
TRPV2 Channels Contribute to Stretch-Activated Cation Currents and Myogenic Constriction in Retinal Arterioles., PMID:27784066
Phage Immunoprecipitation Sequencing of Autoantigens in Autoimmune Retinopathy., PMID:27726466
TRPC6 channel activation promotes neonatal glomerular mesangial cell apoptosis via calcineurin/NFAT and FasL/Fas signaling pathways., PMID:27383564
TRPC6 May Protect Renal Ischemia-Reperfusion Injury Through Inhibiting Necroptosis of Renal Tubular Epithelial Cells., PMID:26913924
Using Phos-Tag in Western Blotting Analysis to Evaluate Protein Phosphorylation., PMID:26676139
TRPC6 channel translocation into phagosomal membrane augments phagosomal function., PMID:26604306
Relationship between calcium mobilization and platelet α- and δ-granule secretion. A role for TRPC6 in thrombin-evoked δ-granule exocytosis., PMID:26386308
Alpha1-Adrenergic Receptor Activation Stimulates Calcium Entry and Proliferation via TRPC6 Channels in Cultured Human Mesangial Cells., PMID:26202353
Focal segmental glomerulosclerosis: molecular genetics and targeted therapies., PMID:26156092
Receptor channel TRPC6 orchestrate the activation of human hepatic stellate cell under hypoxia condition., PMID:25845497
Functional expression of transient receptor potential channels in human endometrial stromal cells during the luteal phase of the menstrual cycle., PMID:25820697
Upregulation and Diverse Roles of TRPC3 and TRPC6 in Synaptic Reorganization of the Mossy Fiber Pathway in Temporal Lobe Epilepsy., PMID:25213992
Reducing endoglin activity limits calcineurin and TRPC-6 expression and improves survival in a mouse model of right ventricular pressure overload., PMID:25015075
IL-17A contributes to brain ischemia reperfusion injury through calpain-TRPC6 pathway in mice., PMID:24928352
Hyperforin attenuates microglia activation and inhibits p65-Ser276 NFκB phosphorylation in the rat piriform cortex following status epilepticus., PMID:24881563
Angiotensin II and canonical transient receptor potential-6 activation stimulate release of a signal transducer and activator of transcription 3-activating factor from mouse podocytes., PMID:24850910
Mechanotransduction channels of the trabecular meshwork., PMID:24215462
Expression and localization of TRPC proteins in rat ventricular myocytes at various developmental stages., PMID:24146259
Involvement of TRPC channels in lung cancer cell differentiation and the correlation analysis in human non-small cell lung cancer., PMID:23840757
STIM1 controls endothelial barrier function independently of Orai1 and Ca2+ entry., PMID:23512989
Knockout of the Trpc1 gene reveals that TRPC1 can promote recovery from anaphylaxis by negatively regulating mast cell TNF-α production., PMID:23489970
DAG-sensitive and Ca(2+) permeable TRPC6 channels are expressed in dentate granule cells and interneurons in the hippocampal formation., PMID:23193081
TRPC channels and their splice variants are essential for promoting human ovarian cancer cell proliferation and tumorigenesis., PMID:22920441
Brain-derived neurotrophic factor activation of CaM-kinase kinase via transient receptor potential canonical channels induces the translation and synaptic incorporation of GluA1-containing calcium-permeable AMPA receptors., PMID:22699894
Mild hypoxia-induced cardiomyocyte hypertrophy via up-regulation of HIF-1α-mediated TRPC signalling., PMID:22129453
Activation of TRPC cationic channels by mercurial compounds confers the cytotoxicity of mercury exposure., PMID:21984481
VEGF regulates TRPC6 channels in podocytes., PMID:21868397
For research use only. Not for human or drug use.
