Catalog No.
PHJ25901
Species reactivity
Human, Mouse, Rat
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human DNER (Glu339-Asn583).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
Delta and Notch-like epidermal growth factor-related receptor, DNER, BET
Purification
Purified by antigen affinity column.
Accession
Q8NFT8
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Anti-Tr/DNER Antibody-Associated Ataxia in a Pediatric Hodgkin Lymphoma Survivor: Successful Treatment With Plasmapheresis and IVIG., PMID:39910728
Autoimmune brainstem encephalitis: Clinical associations, outcomes, and proposed diagnostic criteria., PMID:39708293
Anti-Tr/DNER Antibody-associated Paraneoplastic Neurological Syndrome Presenting Limbic Encephalitis with Anaplastic Large Cell Lymphoma: A Case Report., PMID:39662912
Autoimmune Encephalitis and Paraneoplastic Neurologic Syndromes: A Nationwide Study on Epidemiology and Antibody Testing Performance., PMID:39467237
Plasmapheresis and IVIG for Treatment of Non-Tumor Anti-Tr/DNER Antibody-Associated Ataxia: A Case Report., PMID:38874737
Diagnostic patterns of serum inflammatory protein markers in children with Lyme neuroborreliosis., PMID:38723400
Evaluation of potential prevalence of onconeural antibodies in women with breast cancer., PMID:38518226
Hematologic malignancies and hematopoietic stem cell transplantation., PMID:38494294
Paraneoplastic cerebellar and brainstem disorders., PMID:38494276
Favorable Outcomes in a Case of Non-paraneoplastic DNER Ataxia Treated with Immunotherapy., PMID:37991702
Mimics of Autoimmune Encephalitis: Validation of the 2016 Clinical Autoimmune Encephalitis Criteria., PMID:37582614
Antibodies Associated With Autoimmune Encephalitis in Patients With Presumed Neurodegenerative Dementia., PMID:37311646
Considering a new clinical presentation of the anti-Tr/DNER antibody-associated cerebellar ataxia., PMID:36385322
Anti-Tr/DNER antibody-associated cerebellar ataxia: three rare cases report and literature review., PMID:36094774
Anti-Zic4 paraneoplastic cerebellar degeneration in a patient with EGFR-mutated NSCLC: a case report., PMID:35958343
Cerebellar Ataxia With Anti-DNER Antibodies: Outcomes and Immunologic Features., PMID:35940913
Neuroborreliosis with involvement of rhombencephalon: A case report., PMID:35330755
Update on Paraneoplastic Cerebellar Degeneration., PMID:34827413
Anti-Tr/DNER Antibody-Associated Cerebellar Ataxia: a Systematic Review., PMID:34817790
Hodgkin Lymphoma With Diplopia and Nystagmus: A Paraneoplastic Cerebellar Degeneration With Ectopic Expression of DNER Antigen on Reed-Sternberg Cells., PMID:34782261
Neurological Autoimmunity Associated With Homer-3 Antibody: A Case Series From China., PMID:34580182
Combination of structural MRI, functional MRI and brain PET-CT provide more diagnostic and prognostic value in patients of cerebellar ataxia associated with anti-Tr/DNER: a case report., PMID:34560837
Anti-Tr/DNER antibody paraneoplastic cerebellar degeneration preceding a very late relapse of Hodgkin Lymphoma after 12 years., PMID:34090521
Cerebrospinal fluid, antineuronal autoantibody, EEG, and MRI findings from 992 patients with schizophreniform and affective psychosis., PMID:32782247
BET inhibitors synergize with venetoclax to induce apoptosis in MYC-driven lymphomas with high BCL-2 expression., PMID:32717030
Rhombencephalitis associated with isolated Zic4-antibodies in Paraneoplastic cerebellar degeneration: a case report., PMID:32450842
Autoimmune Vestibulocerebellar Syndromes., PMID:31958862
Neurochondrin Antibody Serum Positivity in Three Cases of Autoimmune Cerebellar Ataxia., PMID:31179511
The Notch ligand DNER regulates macrophage IFNγ release in chronic obstructive pulmonary disease., PMID:31060902
Monitoring of Protein Biomarkers of Inflammation in Human Traumatic Brain Injury Using Microdialysis and Proximity Extension Assay Technology in Neurointensive Care., PMID:31017044
Updates in the Diagnosis and Treatment of Paraneoplastic Neurologic Syndromes., PMID:30415318
Predictive value of electroencephalography in anti-NMDA receptor encephalitis., PMID:30135187
Quantum dot-based immunofluorescent imaging and quantitative detection of DNER and prognostic value in prostate cancer., PMID:29843212
Paraneoplastic cerebellar syndromes associated with antibodies against Purkinje cells., PMID:29199513
DNER and NFIA are expressed by developing and mature AII amacrine cells in the mouse retina., PMID:29071714
Anti-neuronal anti-bodies in patients with early psychosis., PMID:28461116
Microtubule-associated protein 1B: Novel paraneoplastic biomarker., PMID:28074593
Onconeural Antibodies in Acute Psychiatric Inpatient Care., PMID:27578448
Screening for MOG-IgG and 27 other anti-glial and anti-neuronal autoantibodies in 'pattern II multiple sclerosis' and brain biopsy findings in a MOG-IgG-positive case., PMID:26869529
Therapeutic targeting of BET protein BRD4 delays murine lupus., PMID:26590112
'Medusa head ataxia': the expanding spectrum of Purkinje cell antibodies in autoimmune cerebellar ataxia. Part 3: Anti-Yo/CDR2, anti-Nb/AP3B2, PCA-2, anti-Tr/DNER, other antibodies, diagnostic pitfalls, summary and outlook., PMID:26377319
Standardized test for anti-Tr/DNER in patients with paraneoplastic cerebellar degeneration., PMID:25745634
Therapeutic approaches in antibody-associated central nervous system pathologies., PMID:25189679
Antibodies to Delta/notch-like epidermal growth factor-related receptor in patients with anti-Tr, paraneoplastic cerebellar degeneration, and Hodgkin lymphoma., PMID:24935874
Seroprevalence of autoantibodies against brain antigens in health and disease., PMID:24853231
Encephalitis with refractory seizures, status epilepticus, and antibodies to the GABAA receptor: a case series, characterisation of the antigen, and analysis of the effects of antibodies., PMID:24462240
Determination of neuronal antibodies in suspected and definite Creutzfeldt-Jakob disease., PMID:24248099
Paraneoplastic neurological syndromes., PMID:23041955
Identification of delta/notch-like epidermal growth factor-related receptor as the Tr antigen in paraneoplastic cerebellar degeneration., PMID:22447725
Pancreatic islet and progenitor cell surface markers with cell sorting potential., PMID:21947380
For research use only. Not for human or drug use.
