Catalog No.
PHJ82801
Species reactivity
Human, Mouse, Rat
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human DICER1 (Leu6-Ser290).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
DICER, DICER1, Helicase MOI, Endoribonuclease Dicer, Helicase with RNase motif, HERNA, KIAA0928
Purification
Purified by antigen affinity column.
Accession
Q9UPY3
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Focal High-Grade Areas with a Tumor-in-Tumor Pattern: Another Feature of Pediatric DICER1-Associated Thyroid Carcinoma?, PMID:40448797
Exomic and epigenomic analysis of pulmonary blastoma., PMID:39121796
Histone H3 trimethylation on lysine 27 immunostaining pattern in DICER1-associated tumors., PMID:38715664
A comparative mRNA- and miRNA transcriptomics reveals novel molecular signatures associated with metastatic prostate cancers., PMID:36468011
Widespread formation of double-stranded RNAs in testis., PMID:34158368
Pathogenic Germline Variants in Cancer Susceptibility Genes in Children and Young Adults With Rhabdomyosarcoma., PMID:34095712
MicroRNA-497 Reduction and Increase of Its Family Member MicroRNA-424 Lead to Dysregulation of Multiple Inflammation Related Genes in Synovial Fibroblasts With Rheumatoid Arthritis., PMID:33841401
Dicer represses the interferon response and the double-stranded RNA-activated protein kinase pathway in mouse embryonic stem cells., PMID:33837743
Dicer increases the indication for trastuzumab treatment in gastric cancer patients via overexpression of human epidermal growth factor receptor 2., PMID:33772068
Evaluating genomic biomarkers associated with resistance or sensitivity to chemotherapy in patients with advanced breast and colorectal cancer., PMID:32847480
MicroRNA-425-5p Expression Affects BRAF/RAS/MAPK Pathways In Colorectal Cancers., PMID:31673240
Nuclear re-localization of Dicer in primary mouse embryonic fibroblast nuclei following DNA damage., PMID:29394246
Issues with the Specificity of Immunological Reagents for NLRP3: Implications for Age-related Macular Degeneration., PMID:29323137
Whole blood microRNA expression pattern differentiates patients with rheumatoid arthritis, their seropositive first-degree relatives, and healthy unrelated control subjects., PMID:29126434
Suppression of microRNA activity amplifies IFN-γ-induced macrophage activation and promotes anti-tumour immunity., PMID:27295554
Dicer expression in estrogen receptor-positive versus triple-negative breast cancer: an antibody comparison., PMID:27260947
Hypoxia-upregulated microRNA-630 targets Dicer, leading to increased tumor progression., PMID:26725326
Ablation of Dicer leads to widespread perturbation of signaling pathways., PMID:26032504
Dicer is required for maintenance of adult pancreatic acinar cell identity and plays a role in Kras-driven pancreatic neoplasia., PMID:25405615
Downregulated expression of Dicer1 predicts inferior survival in primary gastrointestinal diffuse large B-cell lymphoma treated with CHOP-like regimen and rituximab., PMID:25195038
Human nuclear Dicer restricts the deleterious accumulation of endogenous double-stranded RNA., PMID:24814348
An immunohistochemical and molecular analysis of problematic and unclassified ovarian sex cord-stromal tumors., PMID:24134930
AC1MMYR2, an inhibitor of dicer-mediated biogenesis of Oncomir miR-21, reverses epithelial-mesenchymal transition and suppresses tumor growth and progression., PMID:23811941
Expression of the RNase III enzyme DROSHA is reduced during progression of human cutaneous melanoma., PMID:23370771
Dicer and Drosha expression and response to Bevacizumab-based therapy in advanced colorectal cancer patients., PMID:23266047
Deregulated sex chromosome gene expression with male germ cell-specific loss of Dicer1., PMID:23056286
The RNase III enzyme Dicer is essential for germinal center B-cell formation., PMID:22117047
High expression of Dicer reveals a negative prognostic influence in certain subtypes of primary cutaneous T cell lymphomas., PMID:21937200
Functional dicer is necessary for appropriate specification of radial glia during early development of mouse telencephalon., PMID:21826226
Expression of the ribonucleases Drosha, Dicer, and Ago2 in colorectal carcinomas., PMID:21769619
Deregulation of MYCN, LIN28B and LET7 in a molecular subtype of aggressive high-grade serous ovarian cancers., PMID:21533284
Overexpression of Dicer predicts poor survival in colorectal cancer., PMID:21345667
Genome-wide identification of Ago2 binding sites from mouse embryonic stem cells with and without mature microRNAs., PMID:21258322
MicroRNAs prevent the generation of autoreactive antibodies., PMID:21093320
Dicer is a key player in oocyte maturation., PMID:20827505
MicroRNAs are essential for the developmental switch from neurogenesis to gliogenesis in the developing spinal cord., PMID:20554876
Characterization of the miRNA-RISC loading complex and miRNA-RISC formed in the Drosophila miRNA pathway., PMID:19451544
Dicer is required for female reproductive tract development and fertility in the mouse., PMID:19197916
Dicer ablation affects antibody diversity and cell survival in the B lymphocyte lineage., PMID:18329371
ATP modulates siRNA interactions with an endogenous human Dicer complex., PMID:16177131
Dicer-deficient mouse embryonic stem cells are defective in differentiation and centromeric silencing., PMID:15713842
For research use only. Not for human or drug use.
