Catalog No.
PHB97701
Species reactivity
Human, Mouse, Rat
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human COL4A1 (His1444-Thr1669).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, IF: 1:50-1:100, WB: 1:1000-1:4000
Target
Collagen alpha-1(IV) chain, COL4A1
Purification
Purified by antigen affinity column.
Accession
P02462
Applications
ELISA, IHC, IF, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
A distinct subset of urothelial cells with enhanced EMT features promotes chemotherapy resistance and cancer recurrence by increasing COL4A1-ITGB1 mediated angiogenesis., PMID:38968684
Identifying hub genes in response to ustekinumab and the impact of ustekinumab treatment on fibrosis in Crohn's disease., PMID:38840917
lncRNA CDKN2B-AS1 regulates collagen expression., PMID:38833008
Autophagy activates EGR1 via MAPK/ERK to induce FGF2 in renal tubular cells for fibroblast activation and fibrosis during maladaptive kidney repair., PMID:37978868
Tubular cells produce FGF2 via autophagy after acute kidney injury leading to fibroblast activation and renal fibrosis., PMID:35491858
Autologous hematopoietic stem cell transplantation promotes connective tissue remodeling in systemic sclerosis patients., PMID:35488348
Type IV Collagen Is Essential for Proper Function of Integrin-Mediated Adhesion in Drosophila Muscle Fibers., PMID:31623094
Modulating EGFR-MTORC1-autophagy as a potential therapy for persistent fetal vasculature (PFV) disease., PMID:31462148
Identification of a common epitope in the sequences of COL4A1 and COL6A1 recognized by monoclonal antibody #141., PMID:30321347
C-peptide prevents SMAD3 binding to alpha promoters to inhibit collagen type IV synthesis., PMID:29844093
Identification of COL4A1 as a potential gene conferring trastuzumab resistance in gastric cancer based on bioinformatics analysis., PMID:29512712
Embryo implantation triggers dynamic spatiotemporal expression of the basement membrane toolkit during uterine reprogramming., PMID:27619726
Novel COL4A1 mutation in an infant with severe dysmorphic syndrome with schizencephaly, periventricular calcifications, and cataract resembling congenital infection., PMID:26879631
Normal immunofluorescence pattern of skin basement membranes in a family with porencephaly due to COL4A1 G749S mutation., PMID:26686511
Bone Morphogenetic Protein 4 and Smad1 Mediate Extracellular Matrix Production in the Development of Diabetic Nephropathy., PMID:25995358
Dependence of fibroblast infiltration in tumor stroma on type IV collagen-initiated integrin signal through induction of platelet-derived growth factor., PMID:25686533
Modulation of tumor cell stiffness and migration by type IV collagen through direct activation of integrin signaling pathway., PMID:24823860
Extracellular matrix of adipogenically differentiated mesenchymal stem cells reveals a network of collagen filaments, mostly interwoven by hexagonal structural units., PMID:23851162
Prognostic value of glomerular collagen IV immunofluorescence studies in male patients with X-linked Alport syndrome., PMID:23371956
Arresten, a collagen-derived angiogenesis inhibitor, suppresses invasion of squamous cell carcinoma., PMID:23227231
Antibody blockade of c-fms suppresses the progression of inflammation and injury in early diabetic nephropathy in obese db/db mice., PMID:19466391
Hoxa1 is required for the retinoic acid-induced differentiation of embryonic stem cells into neurons., PMID:18512762
Sox18 is transiently expressed during angiogenesis in granulation tissue of skin wounds with an identical expression pattern to Flk-1 mRNA., PMID:11454981
Ultrastructural, physiological, and molecular defects in the inner ear of a gene-knockout mouse model for autosomal Alport syndrome., PMID:9682811
Serum-stimulated alpha 1 type IV collagen gene transcription is mediated by TGF-beta and inhibited by estradiol., PMID:9486219
Immunohistochemical localization of basement membrane collagens and associated proteins in the murine cochlea., PMID:8844186
Differential expression of two basement membrane collagen genes, COL4A6 and COL4A5, demonstrated by immunofluorescence staining using peptide-specific monoclonal antibodies., PMID:7657706
Purification of the sequence-specific transcription factor CTCBF, involved in the control of human collagen IV genes: subunits with homology to Ku antigen., PMID:7882982
For research use only. Not for human or drug use.
