Catalog No.
PHJ52701
Species reactivity
Human
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human CD169/SIGLEC1 (Gly34-Gly240).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
Siglec-1, CD169, SIGLEC1, SN, Sialic acid-binding Ig-like lectin 1, Sialoadhesin
Purification
Purified by antigen affinity column.
Accession
Q9BZZ2
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Impact of Manganese on Neuronal Function: An Exploratory MultiOmic Study on Ferroalloy Workers in Brescia, Italy., PMID:40385409
Interferon-induced activation of dendritic cells and monocytes by yellow fever vaccination correlates with early antibody responses., PMID:40333758
Macrophages direct location-dependent recall of B cell memory to vaccination., PMID:40300604
Porcine peritoneal macrophages are susceptible to porcine reproductive and respiratory syndrome virus infection., PMID:39723134
Proteomics of circulating extracellular vesicles reveals diverse clinical presentations of COVID-19 but fails to identify viral peptides., PMID:39569406
Development of a Versatile Cancer Vaccine Format Targeting Antigen-Presenting Cells Using Proximity-Based Sortase A-Mediated Ligation of T-Cell Epitopes., PMID:39511711
Pathological Complete Response to Liver Metastasis With Pembrolizumab in a Previously Treated Patient With Microsatellite Instability-high Colorectal Cancer., PMID:39197935
Targeting a STING agonist to perivascular macrophages in prostate tumors delays resistance to androgen deprivation therapy., PMID:39060021
Nanobody-liposomes as novel cancer vaccine platform to efficiently stimulate T cell immunity., PMID:38795934
Elevated unphosphorylated STAT1 and IRF9 in T and B cells of primary sjögren's syndrome: Novel biomarkers for disease activity and subsets., PMID:38788537
Preclinical development of humanized monoclonal antibodies against CD169 as a broad antiviral therapeutic strategy., PMID:38754263
Characterization of in vitro viral neutralization targets of highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV) in alveolar macrophage and evaluation of protection potential against HP-PRRSV challenged based on combination of HP-PRRSV-structure proteins in vitro., PMID:38484577
Dysfunction of sinus macrophages in tumor-bearing host induces resistance to immunotherapy., PMID:37923388
Amyloid-β (Aβ) immunotherapy induced microhemorrhages are associated with activated perivascular macrophages and peripheral monocyte recruitment in Alzheimer's disease mice., PMID:37649100
Breast cancer associated CD169+ macrophages possess broad immunosuppressive functions but enhance antibody secretion by activated B cells., PMID:37404831
Zoledronate/Anti-VEGF Neutralizing Antibody Combination Administration Increases Osteal Macrophages in a Murine Model of MRONJ Stage 0-like Lesions., PMID:36902701
Apoptotic cell fragments locally activate tingible body macrophages in the germinal center., PMID:36868219
CD169-CD43 interaction is involved in erythroblastic island formation and erythroid differentiation., PMID:36861412
CD169+ sinus macrophages in regional lymph nodes do not predict mismatch-repair status of patients with colorectal cancer., PMID:36846928
CD169+ subcapsular sinus macrophage-derived microvesicles are associated with light zone follicular dendritic cells., PMID:35907260
Skeletal muscle provides the immunological micro-milieu for specific plasma cells in anti-synthetase syndrome-associated myositis., PMID:35612662
LA-ICP-MS and Immunohistochemical Staining with Lanthanide-Labeled Antibodies to Study the Uptake of CeO2 Nanoparticles by Macrophages in Tissue Sections., PMID:35583351
SARS-CoV-2 T Cell Response in Severe and Fatal COVID-19 in Primary Antibody Deficiency Patients Without Specific Humoral Immunity., PMID:35359967
CSF-1-induced DC-SIGN+ macrophages are present in the ovarian endometriosis., PMID:35260161
Evaluation of SIGLEC1 in the diagnosis of suspected systemic lupus erythematosus., PMID:34849605
The role of sialic acid-binding immunoglobulin-like-lectin-1 (siglec-1) in immunology and infectious disease., PMID:34494938
CD169 Defines Activated CD14+ Monocytes With Enhanced CD8+ T Cell Activation Capacity., PMID:34394090
Cell Analysis from Dried Blood Spots: New Opportunities in Immunology, Hematology, and Infectious Diseases., PMID:34278739
BTLA Expression and Function Are Impaired on SLE B Cells., PMID:33968071
Asymptomatic COVID-19: disease tolerance with efficient anti-viral immunity against SARS-CoV-2., PMID:33961735
CD169+ lymph node macrophages have protective functions in mouse breast cancer metastasis., PMID:33852863
CD169/SIGLEC1 is expressed on circulating monocytes in COVID-19 and expression levels are associated with disease severity., PMID:33825125
CD169+ Subcapsular Macrophage Role in Antigen Adjuvant Activity., PMID:33815376
Interferon Alpha Favors Macrophage Infection by Visceral Leishmania Species Through Upregulation of Sialoadhesin Expression., PMID:32582193
Characterization of the IgA response to PRRS virus in pig oral fluids., PMID:32126095
Characterisation of a New Human Alveolar Macrophage-Like Cell Line (Daisy)., PMID:31732808
Islet macrophages are associated with islet vascular remodeling and compensatory hyperinsulinemia during diabetes., PMID:31573842
OMIP-061: 20-Color Flow Cytometry Panel for High-Dimensional Characterization of Murine Antigen-Presenting Cells., PMID:31424632
TNF-α induced by porcine reproductive and respiratory syndrome virus inhibits the replication of classical swine fever virus C-strain., PMID:31213269
Anti-Siglec-1 antibodies block Ebola viral uptake and decrease cytoplasmic viral entry., PMID:31160823
Anatomy, immunohistochemistry, and numerical distribution of human splenic microvessels., PMID:31121286
Dendritic Cells From the Cervical Mucosa Capture and Transfer HIV-1 via Siglec-1., PMID:31114569
Activation of CD8⁺ T Cell Responses after Melanoma Antigen Targeting to CD169⁺ Antigen Presenting Cells in Mice and Humans., PMID:30764534
Maea expressed by macrophages, but not erythroblasts, maintains postnatal murine bone marrow erythroblastic islands., PMID:30674470
Immunophenotyping of Sheep Paraffin-Embedded Peripheral Lymph Nodes., PMID:30619264
Signatures of T and B Cell Development, Functional Responses and PD-1 Upregulation After HCMV Latent Infections and Reactivations in Nod.Rag.Gamma Mice Humanized With Cord Blood CD34+ Cells., PMID:30524448
Comparison of Protein and Peptide Targeting for the Development of a CD169-Based Vaccination Strategy Against Melanoma., PMID:30237798
Immune cell census in murine atherosclerosis: cytometry by time of flight illuminates vascular myeloid cell diversity., PMID:29726984
Intracellular replication of Streptococcus pneumoniae inside splenic macrophages serves as a reservoir for septicaemia., PMID:29662129
Long-term culture and differentiation of porcine red bone marrow hematopoietic cells co-cultured with immortalized mesenchymal cells., PMID:28895865
For research use only. Not for human or drug use.
