Catalog No.
PHE84201
Species reactivity
Human, Mouse, Rat
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human IRAK1 (Phe212-Leu434).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
Interleukin-1 receptor-associated kinase 1, IRAK1, IRAK, IRAK-1
Purification
Purified by antigen affinity column.
Accession
P51617
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Identification of soluble biomarkers that associate with distinct manifestations of long COVID., PMID:40307449
A TNIP1-driven systemic autoimmune disorder with elevated IgG4., PMID:39060650
Effects of Aeromonas infection on the immune system, physical barriers and microflora structure in the intestine of juvenile grass carp (Ctenopharyngodon idella)., PMID:39059563
Investigating the therapeutic mechanism of Jiedu-Quyu-Ziyin Fang on systemic lupus erythematosus through the ERα-miRNA-TLR7 immune axis., PMID:38948043
Potential involvement of circulating exosomal miRNA-146a in disease activity and TRAF6 gene expression in juvenile proliferative lupus nephritis., PMID:38355214
ADCT-602, a Novel PBD Dimer-containing Antibody-Drug Conjugate for Treating CD22-positive Hematologic Malignancies., PMID:38324336
IL-33 Suppresses the Progression of Atherosclerosis via the ERK1/2-IRF1-VCAM-1 Pathway., PMID:37957490
Biomarkers in Systemic Sclerosis: An Overview., PMID:37886934
Biomarkers in the Pathogenesis, Diagnosis, and Treatment of Systemic Sclerosis., PMID:37868834
[Novel therapeutic strategy for targeting chronic myeloid leukemia stem cells via IRAK1/4 inhibition]., PMID:37793857
Current landscape of translational and clinical research in myelodysplastic syndromes/neoplasms (MDS): Proceedings from the 1st International Workshop on MDS (iwMDS) Of the International Consortium for MDS (icMDS)., PMID:36934059
Pacritinib abrogates the lupus phenotype in ABIN1[D485N] mice., PMID:36822800
Inhibition of IRAK1 Is an Effective Therapy for Autoimmune Hypophysitis in Mice., PMID:36499283
Paeoniflorin Inhibits LPS-Induced Activation of Splenic CD4+ T Lymphocytes and Relieves Pathological Symptoms in MRL/lpr Mice by Suppressing IRAK1 Signaling., PMID:36467552
Novel Methods of Targeting IL-1 Signalling for the Treatment of Breast Cancer Bone Metastasis., PMID:36230739
Macrophage- and BCR-derived but not TLR-derived signals support the growth of CLL and Richter syndrome murine models in vivo., PMID:36084319
Effects of substituting soybean meal with corn on immune function and gene expression of gut TLR4 pathway of growing goats., PMID:35186490
IRAK1-regulated IFN-γ signaling induces MDSC to facilitate immune evasion in FGFR1-driven hematological malignancies., PMID:34906138
MicroRNA-146a-5p alleviates lipopolysaccharide-induced NLRP3 inflammasome injury and pro-inflammatory cytokine production via the regulation of TRAF6 and IRAK1 in human umbilical vein endothelial cells (HUVECs)., PMID:34733985
SIGIRR Mutation in Human Necrotizing Enterocolitis (NEC) Disrupts STAT3-Dependent microRNA Expression in Neonatal Gut., PMID:34563711
Effect of heparanase inhibitor on tissue factor overexpression in platelets and endothelial cells induced by anti-β2-GPI antibodies., PMID:34107171
Salmonella Typhimurium Adhesin OmpV Activates Host Immunity To Confer Protection against Systemic and Gastrointestinal Infection in Mice., PMID:34097470
Endothelial cells response to neutrophil-derived extracellular vesicles miRNAs in anti-PR3 positive vasculitis., PMID:33527387
Association study between immune-related miRNAs and mixed connective tissue disease., PMID:33430976
miR-146a in Myasthenia Gravis Thymus Bridges Innate Immunity With Autoimmunity and Is Linked to Therapeutic Effects of Corticosteroids., PMID:32210951
MiR-146a relieves kidney injury in mice with systemic lupus erythematosus through regulating NF-κB pathway., PMID:31486503
Triptolide Inhibits Preformed Fibril-Induced Microglial Activation by Targeting the MicroRNA155-5p/SHIP1 Pathway., PMID:31182996
Intravenous administration of cardiac progenitor cell-derived exosomes protects against doxorubicin/trastuzumab-induced cardiac toxicity., PMID:31098627
TLR Signaling Is Activated in Lymph Node-Resident CLL Cells and Is Only Partially Inhibited by Ibrutinib., PMID:30498085
Polysaccharide from Phellinus Igniarius activates TLR4-mediated signaling pathways in macrophages and shows immune adjuvant activity in mice., PMID:30439422
Aggregates of IVIG or Avastin, but not HSA, modify the response to model innate immune response modulating impurities., PMID:30065306
Efficacy of a Virus-Like Nanoparticle As Treatment for a Chronic Viral Infection Is Hindered by IRAK1 Regulation and Antibody Interference., PMID:29354118
miR-21 promotes dengue virus serotype 2 replication in HepG2 cells., PMID:28365456
Deficiency in IRAK4 activity attenuates manifestations of murine Lupus., PMID:28295231
MiR-146a potentially promotes IVIg-mediated inhibition of TLR4 signaling in LPS-activated human monocytes., PMID:28288804
Micro RNA-146a But Not IRAK1 is Associated with Rheumatoid Arthritis in the Tunisian Population., PMID:28207326
Extracellular MicroRNA Signature of Human Helper T Cell Subsets in Health and Autoimmunity., PMID:28077577
Polydatin ameliorates Staphylococcus aureus-induced mastitis in mice via inhibiting TLR2-mediated activation of the p38 MAPK/NF-κB pathway., PMID:27890916
Display of ISKNV orf086 protein on the surface of Aeromonas hydrophila and its immunogenicity in Chinese perch (Siniperca chuatsi)., PMID:27436517
Dual Inhibition of Rip2 and IRAK1/4 Regulates IL-1β and IL-6 in Sarcoidosis Alveolar Macrophages and Peripheral Blood Mononuclear Cells., PMID:27402699
Pin1-Targeted Therapy for Systemic Lupus Erythematosus., PMID:27159270
Legionella pneumophila-Derived Outer Membrane Vesicles Promote Bacterial Replication in Macrophages., PMID:27105429
Anti-TNF-α treatment modulates SASP and SASP-related microRNAs in endothelial cells and in circulating angiogenic cells., PMID:26943583
Salmonella Virulence Factor SsrAB Regulated Factor Modulates Inflammatory Responses by Enhancing the Activation of NF-κB Signaling Pathway., PMID:26673132
Early protein ORF086 is an effective vaccine candidate for infectious spleen and kidney necrosis virus in mandarin fish Siniperca chuatsi., PMID:26099219
TNF-α Induced by Hepatitis C Virus via TLR7 and TLR8 in Hepatocytes Supports Interferon Signaling via an Autocrine Mechanism., PMID:26023919
Activated microglia/macrophage whey acidic protein (AMWAP) inhibits NFκB signaling and induces a neuroprotective phenotype in microglia., PMID:25928566
Involvement of DNA-PKcs in the type I IFN response to CpG-ODNs in conventional dendritic cells in TLR9-dependent or -independent manners., PMID:25812014
Heme oxygenase-1 protects rat liver against warm ischemia/reperfusion injury via TLR2/TLR4-triggered signaling pathways., PMID:25780291
A multilocus genetic study in a cohort of Italian SLE patients confirms the association with STAT4 gene and describes a new association with HCP5 gene., PMID:25369137
For research use only. Not for human or drug use.
