Catalog No.
YHK85601
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Phe64-Ala162
Predicted molecular weight
23.62 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q96T53
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Ghrelin O-acyltransferase, 2.3.1.-, Membrane-bound O-acyltransferase domain-containing protein 4, O-acyltransferase domain-containing protein 4, MBOAT4, GOAT, OACT4, FKSG89
A Modular Customizable Ligand-Conjugate (LC) System Targeting Ghrelin O-Acyltransferase., PMID:40001510
Side-Stream Based Marine Solubles From Atlantic Cod (Gadus morhua) Modulate Appetite and Dietary Nutrient Utilization in Atlantic Salmon (Salmo salar L.) and can Replace Fish Meal., PMID:39949357
The antidiabetic effect of safflower yellow by regulating the GOAT/ghrelin/GHS-R1a/cAMP/TRPM2 pathway., PMID:39934157
The GHSR1a antagonist LEAP2 regulates islet hormone release in a sex-specific manner., PMID:39292603
GOAT rs10096097 and CREB1 rs6740584 single nucleotide polymorphisms are associated with type 2 diabetes mellitus in Egyptians., PMID:38713912
Genetic insights into obesity: in silico identification of pathogenic SNPs in MBOAT4 gene and their structural molecular dynamics consequences., PMID:37921712
Efficacy and safety of the ghrelin-O-acyltransferase inhibitor BI 1356225 in overweight/obesity: Data from two Phase I, randomised, placebo-controlled studies., PMID:36958671
Assessing the Immune Cell Subset and Genetic Mutations in Patients With Palindromic Rheumatism Seronegative for Rheumatoid Factor and Anti-Cyclic Citrullinated Peptide., PMID:35819819
CHST4 might promote the malignancy of cholangiocarcinoma., PMID:35294478
Ghrelin-O-acyltransferase (GOAT) acylates ghrelin in the hippocampus., PMID:35180934
In Search of Small Molecules That Selectively Inhibit MBOAT4., PMID:34946685
Hypoglycemia, Vascular Disease and Cognitive Dysfunction in Diabetes: Insights from Text Mining-Based Reconstruction and Bioinformatics Analysis of the Gene Networks., PMID:34830301
The suppressive effect of REVERBs on ghrelin and GOAT transcription in gastric ghrelin-producing cells., PMID:34450431
Assessing the role of ghrelin and the enzyme ghrelin O-acyltransferase (GOAT) system in food reward, food motivation, and binge eating behavior., PMID:34438062
Ghrelin octanoylation by ghrelin O-acyltransferase: protein acylation impacting metabolic and neuroendocrine signalling., PMID:34315274
A closer look at alcohol-induced changes in the ghrelin system: novel insights from preclinical and clinical data., PMID:33908131
Mouse gastric mucosal endocrine cells are sources and sites of action of Phoenixin-20., PMID:33862165
Predicting the Radiation Sensitivity of Male and Female Rhesus Macaques Using Gene Expression., PMID:33181854
Unacylated-Ghrelin Impairs Hippocampal Neurogenesis and Memory in Mice and Is Altered in Parkinson's Dementia in Humans., PMID:33103129
An overview of ghrelin O-acyltransferase inhibitors: a literature and patent review for 2010-2019., PMID:32564644
Knockdown of ghrelin-O-acyltransferase attenuates colitis through the modulation of inflammatory factors and tight junction proteins in the intestinal epithelium., PMID:32281710
Pregnancy, but not dietary octanoic acid supplementation, stimulates the ghrelin-pituitary growth hormone axis in mice., PMID:32176867
Ghrelin Signaling: GOAT and GHS-R1a Take a LEAP in Complexity., PMID:31636018
The ghrelin O-acyltransferase structure reveals a catalytic channel for transmembrane hormone acylation., PMID:31413115
Biochemical Assays for Ghrelin Acylation and Inhibition of Ghrelin O-Acyltransferase., PMID:31152408
Targeting Peripheral CB1 Receptors Reduces Ethanol Intake via a Gut-Brain Axis., PMID:31105045
ETV5 regulates GOAT/ghrelin system in an mTORC1-dependent manner., PMID:30735697
Ghrelin octanoylation by ghrelin O-acyltransferase: Unique protein biochemistry underlying metabolic signaling., PMID:30626708
Differential expression of the ghrelin-related mRNAs GHS-R1a, GHS-R1b, and MBOAT4 in Japanese patients with schizophrenia., PMID:30597386
Ghrelin cascade changes in the peripheral blood of Japanese patients with Alzheimer's disease., PMID:30366284
Ghrelin-O-Acyltransferase (GOAT) Enzyme as a Novel Potential Biomarker in Gastroenteropancreatic Neuroendocrine Tumors., PMID:30297816
Plasma ghrelin O-acyltransferase (GOAT) enzyme levels: A novel non-invasive diagnosis tool for patients with significant prostate cancer., PMID:30256519
Dietary caprylic acid and ghrelin O-acyltransferase activity to modulate octanoylated ghrelin functions: What is new in this nutritional field?, PMID:30103923
The effect of ghrelin O-acyltransferase inhibitor on gastric H+-K+-ATPase activity and GOAT/ghrelin system in gastric mucosal cells in vitro., PMID:29966658
Functional group and stereochemical requirements for substrate binding by ghrelin O-acyltransferase revealed by unnatural amino acid incorporation., PMID:29738973
Inhibition of ghrelin o-acyltransferase attenuated lipotoxicity by inducing autophagy via AMPK-mTOR pathway., PMID:29713145
Inhibitory Effect of (-)-Epigallocatechin-3-O-gallate on Octanoylated Ghrelin Levels in Vitro and in Vivo., PMID:29607924
Cinnamomum osmophloeum Kanehira ethanol extracts prevents human liver-derived HepG2 cell death from oxidation stress by induction of ghrelin gene expression., PMID:29358557
Desacyl Ghrelin Decreases Anxiety-like Behavior in Male Mice., PMID:29155981
Endogenous ghrelin-O-acyltransferase (GOAT) acylates local ghrelin in the hippocampus., PMID:29063591
Identification and Characterization of a New Series of Ghrelin O-Acyl Transferase Inhibitors., PMID:28846466
The role of acylated-ghrelin in the regulation of sucrose intake., PMID:28652538
The Ghrelin/GOAT System Regulates Obesity-Induced Inflammation in Male Mice., PMID:28368434
Unacylated ghrelin promotes adipogenesis in rodent bone marrow via ghrelin O-acyl transferase and GHS-R1a activity: evidence for target cell-induced acylation., PMID:28361877
Fasting up-regulates ferroportin 1 expression via a Ghrelin/GHSR/MAPK signaling pathway., PMID:28338217
Synthetic Triterpenoid Inhibition of Human Ghrelin O-Acyltransferase: The Involvement of a Functionally Required Cysteine Provides Mechanistic Insight into Ghrelin Acylation., PMID:28134508
Protein interaction mapping interpretation of none alcoholic fatty liver disease model of rats after fat diet feeding., PMID:29511485
Triterpenes suppress octanoylated ghrelin production in ghrelin-expressing human gastric carcinoma cells., PMID:28003581
Reduced intake of carbohydrate prevents the development of obesity and impaired glucose metabolism in ghrelin O-acyltransferase knockout mice., PMID:27816752
Glucose tolerance female-specific QTL mapped in collaborative cross mice., PMID:27807798
For research use only. Not for human or drug use.
