Catalog No.
YHK85501
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gly100-Pro142
Predicted molecular weight
32.97 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q8WYQ3
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Coiled-coil-helix-coiled-coil-helix domain-containing protein 10, mitochondrial, Protein N27C7-4, CHCHD10, C22orf16
Impacts of pathogenic mutations on the structures of the CHCHD10 monomer: An AlphaFold3 study linked to the generation of conformational ensembles., PMID:40490178
har-1/CHCHD10 mutations induce neurodegeneration and mitochondrial fragmentation in Caenorhabditis elegans., PMID:40452868
Dose-dependent CHCHD10 dysregulation dictates motor neuron disease severity and alters creatine metabolism., PMID:40400037
Expression profile of Chchd10 gene during testicular development., PMID:40368000
Clioquinol induces mitochondrial toxicity in SH-SY5Y neuroblastoma cells by affecting the respiratory chain complex IV and OPA1 dynamin-like GTPase., PMID:40125820
The Mia40 substrate Mix17 exposes its N-terminus to the cytosolic side of the mitochondrial outer membrane., PMID:40094392
Identification of novel biomarkers for gastric adenocarcinoma through two-sample Mendelian randomization analysis of the human plasma proteome., PMID:40052612
Dysregulation of mitochondrial α-ketoglutarate dehydrogenase leads to elevated lipid peroxidation in CHCHD2-linked Parkinson's disease models., PMID:40011434
Chchd10: A Novel Metabolic Sensor Modulating Adipose Tissue Homeostasis., PMID:39985288
Bidirectional Mendelian Randomization identifies plasma proteins associated with urticaria risk., PMID:39961865
Identifying Hub Genes and Metabolic Pathways in Collagen VI-Related Dystrophies: A Roadmap to Therapeutic Intervention., PMID:39595553
Nifuroxazide rescues the deleterious effects due to CHCHD10-associated MICOS defects in disease models., PMID:39478664
Effects of the Amyotrophic Lateral Sclerosis-related Q108P Mutation on the Structural Ensemble Characteristics of CHCHD10., PMID:39444183
DELE1 maintains muscle proteostasis to promote growth and survival in mitochondrial myopathy., PMID:39379554
CHCHD10P80L knock-in zebrafish display a mild ALS-like phenotype., PMID:39260590
CHCHD2 P14L, found in amyotrophic lateral sclerosis, exhibits cytoplasmic mislocalization and alters Ca2+ homeostasis., PMID:39131911
Amyloid fibril structures link CHCHD10 and CHCHD2 to neurodegeneration., PMID:39091724
Genetic and clinical landscape of Chinese frontotemporal dementia: dominance of TBK1 and OPTN mutations., PMID:38872230
High fat diet ameliorates mitochondrial cardiomyopathy in CHCHD10 mutant mice., PMID:38724625
CHCHD10S59L/+ mouse model: Behavioral and neuropathological features of frontotemporal dementia., PMID:38583639
DELE1 promotes translation-associated homeostasis, growth, and survival in mitochondrial myopathy., PMID:38529505
Loss of CHCHD2 Stability Coordinates with C1QBP/CHCHD2/CHCHD10 Complex Impairment to Mediate PD-Linked Mitochondrial Dysfunction., PMID:38453793
Multiplex Proteomics in the Identification of Potential Biomarkers of Very Severe Sinusoidal Obstruction Syndrome/Veno-Occlusive Disease in Allogeneic Hematopoietic Cell Transplant Patients Treated with Defibrotide., PMID:38330921
Mitochondrial protein CHCHD10 inhibits NDV replication and reduces pathological changes., PMID:38244394
Simple models to understand complex disease: 10 years of progress from Caenorhabditis elegans models of amyotrophic lateral sclerosis and frontotemporal lobar degeneration., PMID:38239833
NDV inhibited IFN-β secretion through impeding CHCHD10-mediated mitochondrial fusion to promote viral proliferation., PMID:38211361
Disruption of Mitophagy Flux through the PARL-PINK1 Pathway by CHCHD10 Mutations or CHCHD10 Depletion., PMID:38132101
Mitochondria, a Key Target in Amyotrophic Lateral Sclerosis Pathogenesis., PMID:38002924
CHCHD10 mutations induce tissue-specific mitochondrial DNA deletions with a distinct signature., PMID:37815936
The identification of high-performing antibodies for Coiled-coil-helix-coiled-coil-helix domain containing protein 10 (CHCHD10) for use in Western Blot, immunoprecipitation and immunofluorescence., PMID:37767023
Neuroinflammatory Pathways in the ALS-FTD Continuum: A Focus on Genetic Variants., PMID:37628709
The impacts of the mitochondrial myopathy-associated G58R mutation on the dynamic structural properties of CHCHD10., PMID:37349880
Frontotemporal Dementia-Related V57E Mutation Impairs Mitochondrial Function and Alters the Structural Properties of CHCHD10., PMID:37194187
CHCHD2 and CHCHD10-related neurodegeneration: molecular pathogenesis and the path to precision therapy., PMID:37021679
High fat diet ameliorates mitochondrial cardiomyopathy in CHCHD10 mutant mice., PMID:36865125
Loss of mitochondrial Chchd10 or Chchd2 in zebrafish leads to an ALS-like phenotype and Complex I deficiency independent of the mitochondrial integrated stress response., PMID:36799027
Effects of the Jokela type of spinal muscular atrophy-related G66V mutation on the structural ensemble characteristics of CHCHD10., PMID:36625206
Calmodulin Binding Domains in Critical Risk Proteins Involved in Neurodegeneration., PMID:36421678
Single cell analysis of docosahexaenoic acid suppression of sequential LPS-induced proinflammatory and interferon-regulated gene expression in the macrophage., PMID:36405730
Inter-organellar and systemic responses to impaired mitochondrial matrix protein import in skeletal muscle., PMID:36198903
Neurodegeneration-associated mitochondrial proteins, CHCHD2 and CHCHD10-what distinguishes the two?, PMID:36158221
CHCHD2 and CHCHD10: Future therapeutic targets in cognitive disorder and motor neuron disorder., PMID:36061599
Intrinsically disordered proteins and proteins with intrinsically disordered regions in neurodegenerative diseases., PMID:35791387
Modulation of synaptic plasticity, motor unit physiology, and TDP-43 pathology by CHCHD10., PMID:35787294
Pathological characterization of a novel mouse model expressing the PD-linked CHCHD2-T61I mutation., PMID:35786718
Recent Updates on the Genetics of Amyotrophic Lateral Sclerosis and Frontotemporal Dementia., PMID:35768750
CHCHD10 Modulates Thermogenesis of Adipocytes by Regulating Lipolysis., PMID:35709007
OMA1 mediates local and global stress responses against protein misfolding in CHCHD10 mitochondrial myopathy., PMID:35700042
CHCHD10 and SLP2 control the stability of the PHB complex: a key factor for motor neuron viability., PMID:35656794
For research use only. Not for human or drug use.
