Catalog No.
YHG64204
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Thr22-Ala563
Predicted molecular weight
61.58 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
NP_061486.2
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Laminin subunit gamma-2, Cell-scattering factor 140 kDa subunit, CSF 140 kDa subunit, Epiligrin subunit gamma, Kalinin subunit gamma, Kalinin/nicein/epiligrin 100 kDa subunit, Ladsin 140 kDa subunit, Laminin B2t chain, Laminin-5 subunit gamma, Large adhesive scatter factor 140 kDa subunit, Nicein subunit gamma, LAMC2, LAMB2T, LAMNB2, laminin-5, laminin-332, epiligrin, kalinin, nicein
EBV Reactivation-associated gene signature predicts poor prognosis in nasopharyngeal carcinoma., PMID:40457434
Single-cell transcription reveals hepatocyte-to-cholangiocyte reprogramming and biliary gene profile in biliary atresia., PMID:40366121
Anlotinib inhibits c-MET and ITGA2 in the treatment of anaplastic thyroid carcinoma., PMID:40281512
Laminin-γ2-NR6A1 Fusion Protein Promotes Metastatic Potential in Non-Small-Cell Lung Carcinoma Cells without Epidermal Growth Factor Receptor Mutation., PMID:40252971
Identification of Specific Biomarkers for Anaplastic Thyroid Carcinoma Through Spatial Transcriptomic and Immunohistochemical Profiling., PMID:40244468
A model of basement membrane-related regulators for prediction of prognoses in esophageal cancer and verification in vitro., PMID:40234833
EGFR-mediated local invasiveness and response to Cetuximab in head and neck cancer., PMID:40121428
A single-cell map of patients with non-small cell lung cancer harboring rare-driver mutations after anti-PD-1 treatment., PMID:40021042
miR-212-5p Regulates PM2.5-Induced Apoptosis by Targeting LAMC2 and LAMA3., PMID:40004224
Knockdown of LAMA3 enhances the sensitivity of colon cancer to oxaliplatin by regulating the Hippo-YAP pathway., PMID:39798821
Anticancer and therapeutic efficacy of XPO1 inhibition in pancreatic ductal adenocarcinoma through DNA damage and modulation of miR-193b/KRAS/LAMC2/ERK/AKT signaling cascade., PMID:39778762
Fructo-Oligosaccharides Enhance the Expression of Genes Related to Focal Adhesion- and Inflammation-Pathways in Small Intestinal Absorptive Caco-2 Cells., PMID:39756968
ERO1A levels are a prognostic indicator in EGFR mutated non small cell lung cancer., PMID:39496753
Serum laminin γ2 monomer as a predictive biomarker for hepatocellular carcinoma in patients with chronic hepatitis B virus infection: a retrospective cohort study., PMID:39455696
Anti-Laminin β4 IgG Drives Tissue Damage in Anti-p200 Pemphigoid and Shows Interactions with Laminin α3 and γ1/2 Chains., PMID:39320300
20(S)-Ginsenoside Rh2 overcomes gemcitabine resistance in pancreatic cancer by inhibiting LAMC2-Modulated ABC transporters., PMID:39270979
TNF Induces Laminin-332-Encoding Genes in Endothelial Cells and Laminin-332 Promotes an Atherogenic Endothelial Phenotype., PMID:39201392
Identification of hub genes and key modules in laryngeal squamous cell carcinoma., PMID:39145051
Expression of the laminin genes family and its relationship to prognosis in pancreatic carcinoma., PMID:39039002
MAP3K8 is a potential therapeutic target in airway epithelial inflammation., PMID:39030600
Tibial cortex transverse transport surgery improves wound healing in patients with severe type 2 DFUs by activating a systemic immune response: a cross-sectional study., PMID:38954658
Hepatocyte transformation is induced by laminin γ2 monomer., PMID:38951133
Dissecting Crucial Gene Markers Involved in HPV-Associated Oropharyngeal Squamous Cell Carcinoma from RNA-Sequencing Data through Explainable Artificial Intelligence., PMID:38940026
Identification of exosomal microRNAs and related hub genes associated with imatinib resistance in chronic myeloid leukemia., PMID:38916832
Understanding the dynamics of TKI-induced changes in the tumor immune microenvironment for improved therapeutic effect., PMID:38908857
Identification of key modules and hub genes involved in regulating the feather follicle development of Wannan chickens using WGCNA., PMID:38908121
Bulk and single-cell RNA sequencing reveal the contribution of laminin γ2 -CD44 to the immune resistance in lymphocyte-infiltrated squamous lung cancer subtype., PMID:38803944
Leptin Promotes Vasculogenic Mimicry in Breast Cancer Cells by Regulating Aquaporin-1., PMID:38791252
Extracellular matrix marker LAMC2 targets ZEB1 to promote TNBC malignancy via up-regulating CD44/STAT3 signaling pathway., PMID:38760717
LAMC2 regulates the proliferation, invasion, and metastasis of gastric cancer via PI3K/Akt signaling pathway., PMID:38703300
Junctional Epidermolysis Bullosa Linked to Homozygous Mutation in LAMC2 Gene: A Case Report With Eosinophil-Rich Inflammatory Infiltrate., PMID:38648026
Oncogenic Roles of Laminin Subunit Gamma-2 in Intrahepatic Cholangiocarcinoma via Promoting EGFR Translation., PMID:38526177
YAP/TAZ-mediated regulation of laminin 332 is enabled by β4 integrin repression of ZEB1 to promote ferroptosis resistance., PMID:38508310
Knockdown of ribosome RNA processing protein 15 suppresses migration of hepatocellular carcinoma through inhibiting PATZ1-associated LAMC2/FAK pathway., PMID:38475740
Cellular senescence is associated with the spatial evolution toward a higher metastatic phenotype in colorectal cancer., PMID:38446659
Phenotypic differences in intermediate generalized junctional epidermolysis bullosa with homozygous LAMC2 mutation and a potential genetic modifier., PMID:38376117
Endothelium-specific deletion of p62 causes organ fibrosis and cardiac dysfunction., PMID:38365674
Machine learning identifies SLC6A14 as a novel biomarker promoting the proliferation and metastasis of pancreatic cancer via Wnt/β-catenin signaling., PMID:38267509
Capsaicin and Cold exposure promote EMT-mediated premetastatic niche formation to facilitate colorectal cancer metastasis., PMID:38169517
Genotype-Phenotype Correlation in Junctional Epidermolysis Bullosa: Signposts to Severity., PMID:38157931
Crucial Roles of the Mesenchymal Androgen Receptor in Wolffian Duct Development., PMID:38146640
Upregulated LAMA3 modulates proliferation, adhesion, migration and epithelial‑to‑mesenchymal transition of cholangiocarcinoma cells., PMID:38114514
Release of miR-29 Target Laminin C2 Improves Skin Repair., PMID:37981221
LAMC2 mitigates ER stress by enhancing ER-mitochondria interaction via binding to MYH9 and MYH10., PMID:37891404
Dystonin modifiers of junctional epidermolysis bullosa and models of epidermolysis bullosa simplex without dystonia musculorum., PMID:37883475
Migration-inducing gene-7 promotes glioma cell proliferation and invasiveness via activating the MAPK signaling pathway., PMID:37789777
Laminin 332 expression levels predict clinical outcomes and chemotherapy response in patients with pancreatic adenocarcinoma., PMID:37779898
Immuno-oncologic signature of malignant transformation in oral squamous cell carcinoma., PMID:37739913
Engineered TCR T-cell therapy targeting mass spectrometry-identified natural epitope in PDAC., PMID:37640197
Analyses of damage-associated molecular patterns, particularly biglycan, in cisplatin-induced rat progressive renal fibrosis., PMID:37577365
For research use only. Not for human or drug use.
