Catalog No.
EMJ44301
Expression system
Mammalian Cells
Species
Mus musculus (Mouse)
Protein length
Val18-Tyr435
Predicted molecular weight
51.42 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O89017
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Legumain, 3.4.22.34, Asparaginyl endopeptidase, Protease, cysteine 1, Lgmn, Prsc1
Transcriptome and proteome profile analysis of the regulation of chicken ovarian development., PMID:40466268
Cystatin 6 (CST6) and Legumain (LGMN) are potential mediators in the pathogenesis of preeclampsia., PMID:40234537
Soluble-microneedle enhance three T-cell activation signals as efficient tumor vaccines for melanoma prevention and treatment., PMID:40233828
Legumain In Situ Engineering Promotes Efferocytosis of CAR Macrophage to Treat Cardiac Fibrosis., PMID:40223483
Predictive potential of combined secretomics and image-based morphometry as a non-invasive method for selecting implanting embryos., PMID:40221726
The CD163 + tissue-infiltrating macrophages regulate ferroptosis in thyroid-associated ophthalmopathy orbital fibroblasts via the TGF-β/Smad2/3 signaling pathway., PMID:40211281
Targeting legumain-mediated cell-cell interaction sensitizes glioblastoma to immunotherapy in preclinical models., PMID:40131864
Pulmonary exposure to renewable diesel exhaust particles alters protein expression and toxicity profiles in bronchoalveolar lavage fluid and plasma of mice., PMID:39739031
Legumain deficiency halts atherogenesis by modulating T cell receptor signaling., PMID:39473192
Proteomic Characterization of Ubiquitin Carboxyl-Terminal Hydrolase 19 Deficient Cells Reveals a Role for USP19 in the Secretion of Lysosomal Proteins., PMID:39389361
Legumain/asparaginyl endopeptidase-resistant tau fibril fold produces corticobasal degeneration-specific C-terminal tau fragment., PMID:39353514
Integrated multi-omic high-throughput strategies across-species identified potential key diagnostic, prognostic, and therapeutic targets for atherosclerosis under high glucose conditions., PMID:39223351
Mutual exclusivity and co-occurrence patterns of immune checkpoints indicate NKG2A relates to anti-PD-1 resistance in gastric cancer., PMID:39097734
Investigation of prognostic values of immune infiltration and LGMN expression in the microenvironment of osteosarcoma., PMID:38980440
Assessment of circulating proteins in thyroid cancer: Proteome-wide Mendelian randomization and colocalization analysis., PMID:38947504
Quantitative proteomics reveals cellular responses to individual mAb expression and tunicamycin in CHO cells., PMID:38896138
Four-Dimensional Label-Free Quantitative Proteomics of Ginsenoside Rg2 Ameliorated Scopolamine-Induced Memory Impairment in Mice through the Lysosomal Pathway., PMID:38885433
Legumain-deficient macrophages regulate inflammation and lipid metabolism in adipose tissues to protect against diet-induced obesity., PMID:38815795
Multi-omics analysis identifies sex-specific hepatic protein-metabolite networks in yellow catfish (Pelteobagrus fulvidraco) exposed to chronic hypoxia., PMID:38677698
Protection against overfeeding-induced weight gain is preserved in obesity but does not require FGF21 or MC4R., PMID:38331907
The Cysteine Protease Legumain Is Upregulated by Vitamin D and Is a Regulator of Vitamin D Metabolism in Mice., PMID:38201240
Pigmented Microbial Extract (PMB) from Exiguobacterium Species MB2 Strain (PMB1) and Bacillus subtilis Strain MB1 (PMB2) Inhibited Breast Cancer Cells Growth In Vivo and In Vitro., PMID:38139241
Immune modulation of goat monocytes by Fasciola gigantica Legumain-1 protein (Fg-LGMN-1)., PMID:38081528
CD4+ T-Cell Legumain Deficiency Attenuates Hypertensive Damage via Preservation of TRAF6., PMID:38047378
The transcriptional and phenotypic characteristics that define alveolar macrophage subsets in acute hypoxemic respiratory failure., PMID:37978185
Weighted gene co-expression network analysis and machine learning identified the lipid metabolism-related gene LGMN as a novel biomarker for keloid., PMID:37930112
Data-Independent Acquisition Mass Spectrometry Analysis of FFPE Rectal Cancer Samples Offers In-Depth Proteomics Characterization of the Response to Neoadjuvant Chemoradiotherapy., PMID:37895091
Hypoxia-driven protease legumain promotes immunosuppression in glioblastoma., PMID:37858339
Integrated multi-omics reveals the beneficial role of chlorogenic acid in improving the growth performance and immune function of immunologically stressed broilers., PMID:37635925
The presence of blastocyst within the uteri facilitates lumenal epithelium transformation for implantation via upregulating lysosome proteostasis activity., PMID:37584546
Downregulation of lysosomal trafficking in ARPE19 cells leads to decreased transfection efficiency at high passage., PMID:37546846
Accumulation of plasmacytoid dendritic cell is associated with a treatment response to DNA-damaging treatment and favorable prognosis in lung adenocarcinoma., PMID:37435086
Integrated analysis of methylation profiles and transcriptome of Marek's disease virus-infected chicken spleens reveal hypomethylation of CD4 and HMGB1 genes might promote Marek's disease tumorigenesis., PMID:37043960
NQO1 regulates expression and alternative splicing of apoptotic genes associated with Alzheimer's disease in PC12 cells., PMID:37002649
Role of LGMN in tumor development and its progression and connection with the tumor microenvironment., PMID:36825203
Identification of Novel Plasma Biomarkers for Abdominal Aortic Aneurysm by Protein Array Analysis., PMID:36551281
The Heterogeneity of Tumour-Associated Macrophages Contributes to the Recurrence and Outcomes of Glioblastoma Patients., PMID:36542317
DAP12 deletion causes age-related motor function impairment but promotes functional recovery after sciatic nerve crush injury., PMID:36503041
Metformin regulates autophagy via LGMN to inhibit choriocarcinoma., PMID:36464174
A review on the role of PCGEM1 lncRNA in cancer., PMID:36403313
Fetal Programming of the Endocrine Pancreas: Impact of a Maternal Low-Protein Diet on Gene Expression in the Perinatal Rat Pancreas., PMID:36232358
Legumain affects the PI3K/AKT tumor progression pathway in retinoblastoma., PMID:36041510
Autocrine pro-legumain promotes breast cancer metastasis via binding to integrin αvβ3., PMID:35854065
ScRNA-seq expression of IFI27 and APOC2 identifies four alveolar macrophage superclusters in healthy BALF., PMID:35820705
Cerebrospinal Fluid in Classical Trigeminal Neuralgia: An Exploratory Study on Candidate Biomarkers., PMID:35625736
Circadian Regulator CLOCK Drives Immunosuppression in Glioblastoma., PMID:35413115
Neuronal C/EBPβ/AEP pathway shortens life span via selective GABAnergic neuronal degeneration by FOXO repression., PMID:35353567
Expression of extracellular matrix proteins nidogen-1 and legumain in endometrial carcinomas., PMID:35128760
Legumain Is an Endogenous Modulator of Integrin αvβ3 Triggering Vascular Degeneration, Dissection, and Rupture., PMID:35100526
Identification of the Cysteine Protease Legumain as a Potential Chronic Hypoxia-Specific Multiple Myeloma Target Gene., PMID:35053409
For research use only. Not for human or drug use.
