Catalog No.
EHC13502
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
His25-Ser153
Predicted molecular weight
17.86 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P05112
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Interleukin-4, IL-4, B-cell stimulatory factor 1, BSF-1, Binetrakin, Lymphocyte stimulatory factor 1, Pitrakinra, IL4
Evaluation of 'Cytorisk Index' (IL-6*survivin/IL-4 ratio) as a predictor of tumour aggression in breast cancer., PMID:40435911
Association of IL4 (Rs2243250) Gene Variant and Mycoplasma Pneumoniae Infection with Asthma Susceptibility in an Iraqi Population., PMID:40420775
Blocking of IL-4/IL-13 Signalling With Dupilumab Results in Restoration of Serum and Cutaneous Abnormalities in Netherton Syndrome., PMID:40344324
Evaluation of pruritus biomarkers expression in chronic spontaneous urticaria., PMID:40261414
[Observation of the efficacy of dupilumab for treatment of atopic dermatitis in the elderly]., PMID:40219560
Plasma IL4 Levels Linked to Pulmonary Hypertension Severity and Outcome., PMID:40210614
PLM-IL4: Enhancing IL-4-inducing peptide prediction with protein language model., PMID:40203796
MiR-135a-5p/STAT6-mediated EMT regulates IL-4 secretion in non-small cell lung cancer to affect M2-like TAM polarization., PMID:40199139
The role of LINC00114 in atopic dermatitis: modulating inflammation and epidermal barrier dysfunction., PMID:40167775
Semaphorin 7a Regulates the Expression of IL-4 and IL-33 in a Cell Model of Atopic Dermatitis and Is Associated With Disease Severity., PMID:40129061
Younger severe asthma patients with interleukin 4 (CC variant) and dupilumab treatment are more likely to achieve clinical remission., PMID:40119276
LKB1 activated by NaB inhibits the IL-4/STAT6 axis and ameliorates renal fibrosis through the suppression of M2 macrophage polarization., PMID:40097066
Phenotype-endotype relationship in elderly atopic dermatitis and effects of dupilumab therapy: prospective study., PMID:40095170
Cellular morphometry of the neoplastic microenvironment and its association with the immunoexpression of interleukin-4., PMID:40058089
Antagonizing Il10 and Il4 signaling via intracerebral decoy receptor expression attenuates Aβ accumulation., PMID:40055831
Monocyte-derived Langerhans cells express Delta-like 4 induced by peptidoglycan and interleukin-4 mediated suppression., PMID:40018044
Stellate ganglia block reduces airway hyperresponsiveness with modulates the IKK/NF-κB/IL-4/IL-5/IL-13 pathway., PMID:39985034
OM85 ameliorates bleomycin-induced pulmonary fibrosis in mice by inhibiting Notch expression and modulating the IFN-γ/IL-4 ratio., PMID:39948140
Changes and clinical significance of serum vitamin A, 25-(OH)D3, TG2, IL-4 and IL-13 levels in children with eczema., PMID:39921740
IL-4 induces CD22 expression to restrain the effector program of virtual memory T cells., PMID:39919198
STAT6 mutations compensate for CREBBP mutations and hyperactivate IL4/STAT6/RRAGD/mTOR signaling in follicular lymphoma., PMID:39910284
IL-4-primed human umbilical cord mesenchymal stem cells-derived extracellular vesicles facilitate recovery in spinal cord injury via the miR-21-5p/PDCD4-mediated shifting of macrophage M1/M2 polarization., PMID:39909387
NLRP3 deficiency aggravated DNFB-induced chronic itch by enhancing type 2 immunity IL-4/TSLP-TRPA1 axis in mice., PMID:39867900
Basophil-Derived IL-4 Production and Its Potential Pro-Tumoural Role in Th2-Polarisation Within Sentinel Lymph Nodes of Primary Cutaneous Melanoma., PMID:39865442
Genetic variation in IL-4 activated tissue resident macrophages determines strain-specific synergistic responses to LPS epigenetically., PMID:39863579
IL-4, TSLP and IL-31 Cytokine Profiles as Related to Psychometric Measures in Patients with Mastocytosis., PMID:39859245
Simple dysmood disorder, a mild subtype of major depression, is not an inflammatory condition: Depletion of the compensatory immunoregulatory system., PMID:39848470
Improvement of IL-4, IL-6, IL-10, TNF-α and IFN-γ in children with mycoplasma pneumonia through the combination of video scenario-based breathing training and antibiotics., PMID:39806240
Replication Study and Meta-Analysis of the Contribution of Seven Genetic Polymorphisms in Immune-Related Genes to the Risk of Gastric and Colorectal Cancers., PMID:39800859
The Association of TSLP and IL-4 with Patient-Reported Outcome Measures in Chronic Rhinosinusitis with Nasal Polyps., PMID:39791191
Production of the Key Immunoregulatory Cytokines and the Content of FoxP3+ T-Regulatory Lymphocytes in the Epicardial and Thymus Adipose Tissue in Patients with Coronary Heart Disease., PMID:39762697
Pesticide exposure promotes disease activity by decreasing lymphoproliferative activity and increasing IL-4 production in systemic sclerosis patients., PMID:39726168
Characterisation and Profiling of Standard Atopic Dermatitis Therapies in a Chronic Dermatitis Murine Model Induced by Oxazolone., PMID:39715989
Diagnostic Value of IL-4, IL-10, and Neutrophil/Lymphocyte Ratio in Febrile Seizures During Viral Epidemic Period., PMID:39714524
Heart Rate Variability and Cytokines are Involved in Anxiety in Breast Cancer Patients: A Cross-Sectional Study., PMID:39706708
Adiponectin, resistin, interleukin-4 and TGF-β2 levels in treatment resistant schizophrenia patients., PMID:39701174
Early-life IL-4 administration induces long-term changes in microglia in the cerebellum and prefrontal cortex., PMID:39676699
Investigation of the circulatory microRNAs and their involvement in regulation of inflammation in patients with COVID-19., PMID:39667207
Interleukin-4 promotes the clearance of amyloid-β by monocyte through enhancing the recognition and intracellular processing of amyloid-β., PMID:39660534
Computational Insight in the Identification of Non-Synonymous Single-Nucleotide Polymorphism Affecting the Structure and Function of Interleukin-4., PMID:39648289
Leukemia inhibitory factor (LIF) receptor amplifies pathogenic activation of fibroblasts in lung fibrosis., PMID:39636853
CCR4+Tfh2 cells specifically produce IL-4 driving the pathological reaction in IgG4-related disease., PMID:39625839
Reduced thymic IL-4 impairs negative T cell selection in nonobese diabetic mice., PMID:39621313
Effect of linex treatment on IFN-γ and IL-4 in mice infected with Trichinella., PMID:39609767
Multi-locus high-risk alleles association from interleukin's genes with female infertility and certain comorbidities., PMID:39580416
Association between 25-hydroxy vitamin D, interleukin-4, and interferon-γ levels and asthma in children with Mycoplasma pneumonia infection., PMID:39572779
Selective regulation of IFN-γ and IL-4 co-producing unconventional T cells by purinergic signaling., PMID:39560665
Sorafenib-induced macrophage extracellular traps via ARHGDIG/IL4/PADI4 axis confer drug resistance through inhibiting ferroptosis in hepatocellular carcinoma., PMID:39529192
Characterization of CD8+ virtual memory T cells in IL-4 knockout mice using single-cell RNA sequencing., PMID:39515094
Diphencyprone reduces the CD8+ lymphocytes and IL-4 and enhences IgG2a/IgG1 ratio in pathogenicity of acute leishmania major infection in BALB/c mice., PMID:39488893
For research use only. Not for human or drug use.
