Catalog No.
EHH55901
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
Ser19-Glu351
Predicted molecular weight
66.13 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q6UXV0
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
GDNF family receptor alpha-like, GFRAL, C6orf144, UNQ9356/PRO34128
Growth Differentiation Factor 15 Induces Gastric Fundus Contraction Involving Cholinergic Excitation: Morphofunctional Evidence in Rodent Models., PMID:40464681
Biology of RET receptor and its ligands: focus on the nervous system., PMID:40272927
GDF15 links adipose tissue lipolysis with anxiety., PMID:40234625
Deletion of GFRAL blunts weight lowering effects of FGF21 in female mice., PMID:40167255
Mapping growth differentiation factor-15 (GDF15)-mediated signaling pathways in cancer: insights into its role across different cancer types., PMID:40128491
GDF15 Analogues Acting as GFRAL Ligands., PMID:39907315
Molecular and Functional Significance of Growth Differentiation Factor-15: A Review on Cardiovascular-Kidney-Metabolic Biomarker., PMID:39781722
Selpercatinib mitigates cancer cachexia independent of anti-tumor activity in the HT1080 tumor model., PMID:39778760
Brainstem BDNF neurons are downstream of GFRAL/GLP1R signalling., PMID:39737892
A systematic review of the neuroprotective role and biomarker potential of GDF15 in neurodegeneration., PMID:39737171
Targeting the GDF15 Signalling for Obesity Treatment: Recent Advances and Emerging Challenges., PMID:39700016
GDF15-GFRAL signaling drives weight loss and lipid metabolism in mouse model of amyotrophic lateral sclerosis., PMID:39672239
GDF15/MIC-1: a stress-induced immunosuppressive factor which promotes the aging process., PMID:39643709
GDNF family receptor alpha-like (GFRAL) expression is restricted to the caudal brainstem., PMID:39608751
GDF15 is required for maintaining subcutaneous adipose tissue lipid metabolic signature., PMID:39505926
GDF15 is still a mystery hormone., PMID:39472228
GB18-06, a nanobody targeting GDF15, effectively alleviates weight loss and restores physical function in cachexia models., PMID:39400041
Neutralizing antibody against GDF15 for treatment of cancer-associated cachexia., PMID:39172988
A Growth Differentiation Factor 15 Receptor Agonist in Randomized Placebo-Controlled Trials in Healthy or Obese Persons., PMID:39148430
PTER is a N-acetyltaurine hydrolase that regulates feeding and obesity., PMID:39112712
Bitter-tasting drugs tune GDF15 and GLP-1 expression via bitter taste or motilin receptors in the intestine of patients with obesity., PMID:39111389
Growth differentiation factor 15: Emerging role in liver diseases., PMID:39111112
Central mechanisms of emesis: A role for GDF15., PMID:39108013
Comprehensive Role of GDF15 in Inhibiting Adipogenesis and Hyperlipidemia, Enhancing Cardiovascular Health and Alleviating Inflammation in Metabolic Disorders., PMID:38934286
Fibroblast Smad7 Induction Protects the Remodeling Pressure-Overloaded Heart., PMID:38899461
Area postrema neurons mediate interleukin-6 function in cancer cachexia., PMID:38824130
Overview of growth differentiation factor 15 (GDF15) in metabolic diseases., PMID:38810400
Total and H-specific growth/differentiation factor 15 levels are unaffected by liraglutide or naltrexone/bupropion administration., PMID:38757729
GDF15 controls primary cilia morphology and function thereby affecting progenitor proliferation., PMID:38719753
Plasma proteomic biomarkers and the association between poor cardiovascular health and incident dementia: The UK Biobank study., PMID:38710337
GFRAL Is Widely Distributed in the Brain and Peripheral Tissues of Mice., PMID:38474863
Preventing obesity, insulin resistance and type 2 diabetes by targeting MT1-MMP., PMID:38367902
Growth/differentiation factor 15 controls ependymal and stem cell number in the V-SVZ., PMID:38366596
Artesunate treats obesity in male mice and non-human primates through GDF15/GFRAL signalling axis., PMID:38310105
Lung Epithelium Releases Growth Differentiation Factor 15 in Response to Pathogen-mediated Injury., PMID:38301257
GDF-15 Inhibits ADP-Induced Human Platelet Aggregation through the GFRAL/RET Signaling Complex., PMID:38254638
The gastrointestinal tract is a major source of the acute metformin-stimulated rise in GDF15., PMID:38253650
GDF15 activates AMPK and inhibits gluconeogenesis and fibrosis in the liver by attenuating the TGF-β1/SMAD3 pathway., PMID:38176644
Genetic variants identified in novel candidate genes for anorexia nervosa and analysis of molecular pathways for diagnostic applications., PMID:38112957
GDF15 is a major determinant of ketogenic diet-induced weight loss., PMID:38056430
Growth differentiation factor-15 is an IFN-γ regulated mediator of infection-induced weight loss and the hepatic FGF21 response., PMID:38013040
Growth differentiation factor-15 stimulates the synthesis of corticotropin-releasing factor in hypothalamic 4B cells., PMID:37918484
Fatty Acids Increase GDF15 and Reduce Food Intake Through a GFRAL Signaling Axis., PMID:37847913
Immunization with a multi-antigen targeted DNA vaccine eliminates chemoresistant pancreatic cancer by disrupting tumor-stromal cell crosstalk., PMID:37814317
Cross-species comparison of pregnancy-induced GDF15., PMID:37584611
Creation of a Peptide Antagonist of the GFRAL-RET Receptor Complex for the Treatment of GDF15-Induced Malaise., PMID:37506293
Identification of GDF15 peptide fragments inhibiting GFRAL receptor signaling., PMID:37495041
GDF15 increases insulin action in the liver and adipose tissue via a β-adrenergic receptor-mediated mechanism., PMID:37473755
GDF15 enhances body weight and adiposity reduction in obese mice by leveraging the leptin pathway., PMID:37433299
GDF15 promotes weight loss by enhancing energy expenditure in muscle., PMID:37380764
For research use only. Not for human or drug use.
