Catalog No.
EHB08202
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
Asp45-Ser169
Predicted molecular weight
16.70 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O75084
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Frizzled-7, Fz-7, hFz7, FzE3, FZD7
G-protein-coupled receptor FZD7 as a therapeutic target in glioblastoma: Multi-cohort validation and identification of Cycloartobiloxanthone as an inhibitor., PMID:40412223
Non-canonical Wnt signaling promotes epithelial fluidization in the repairing airway., PMID:40319020
YTHDF1-mediated m6A modification promotes cisplatin resistance in ovarian cancer via the FZD7/Wnt/β-catenin pathway., PMID:40281310
Identification of FZD7 as a potential ferroptosis-related diagnostic gene in endometriosis by bioinformatics analysis., PMID:40021920
Frizzled-7-targeting antibody-derived bifunctional protein retargets NK cells against triple-negative breast cancer cells via MICA-NKG2D axis., PMID:40021214
Selective activation of FZD2 and FZD7 reveals non-redundant function during mesoderm differentiation., PMID:39824186
Silencing of FZD7 Inhibits Endometriotic Cell Viability, Migration, and Angiogenesis by Promoting Ferroptosis., PMID:39797998
Antibody/siRNA Nanocarriers Against Wnt Signaling Suppress Oncogenic and Stem-Like Behavior in Triple-Negative Breast Cancer Cells., PMID:39760151
A Putative Frizzled 7-Targeting Compound Acts as a Firefly Luciferase Inhibitor., PMID:39670643
SIRT7 stabilizes β-catenin and promotes canonical Wnt activation via upregulating FZD7., PMID:39542206
Peptide Cy RL-QN15 accelerates hair regeneration in diabetic mice by binding to the Frizzled-7 receptor., PMID:39479995
Structural basis of frizzled 7 activation and allosteric regulation., PMID:39198452
Integrin-linked kinase-frizzled 7 interaction maintains cancer stem cells to drive platinum resistance in ovarian cancer., PMID:38822429
HAS2 facilitates glioma cell malignancy and suppresses ferroptosis in an FZD7-dependent manner., PMID:38816349
Mulberry Leaf-Derived Morin Activates β-Catenin by Binding to Frizzled7 to Promote Intestinal Stem Cell Expansion upon Heat-Stable Enterotoxin b Injury., PMID:38651967
Mechanism of miR-548b-5p down-regulating FZD7 to impede the migratory and invasive behavior of gastric carcinoma cells., PMID:38279460
WNT7A promotes tumorigenesis of head and neck squamous cell carcinoma via activating FZD7/JAK1/STAT3 signaling., PMID:38246919
Bioinformatics analysis and experimental validation reveal the anti-ferroptosis effect of FZD7 in acute kidney injury., PMID:38071893
FZD7: A potential biomarker for endometriosis., PMID:37800830
C. difficile intoxicates neurons and pericytes to drive neurogenic inflammation., PMID:37699522
Structure-Based Ligand Discovery Targeting the Transmembrane Domain of Frizzled Receptor FZD7., PMID:37669317
NanoBiT- and NanoBiT/BRET-based assays allow the analysis of binding kinetics of Wnt-3a to endogenous Frizzled 7 in a colorectal cancer model., PMID:37055379
Frizzled 7 modulates goblet and Paneth cell fate, and maintains homeostasis in mouse intestine., PMID:36691900
Frizzled-7-targeting antibody (SHH002-hu1) potently suppresses non-small-cell lung cancer via Wnt/β-catenin signaling., PMID:36625184
An epitope-directed selection strategy facilitating the identification of Frizzled receptor selective antibodies., PMID:36513066
MiR-1-3p enhances the sensitivity of ovarian cancer cells to ferroptosis by targeting FZD7., PMID:36481629
An investigation of bacteriocin nisin anti-cancer effects and FZD7 protein interactions in liver cancer cells., PMID:36084725
FZD7 accelerates hepatic metastases in pancreatic cancer by strengthening EMT and stemness associated with TGF-β/SMAD3 signaling., PMID:35854234
GIPC2 interacts with Fzd7 to promote prostate cancer metastasis by activating WNT signaling., PMID:35347223
Epigenetic repression of Wnt receptors in AD: a role for Sirtuin2-induced H4K16ac deacetylation of Frizzled1 and Frizzled7 promoters., PMID:35296808
A FZD7-specific Antibody-Drug Conjugate Induces Ovarian Tumor Regression in Preclinical Models., PMID:34667113
Activation of Frizzled-7 attenuates blood-brain barrier disruption through Dvl/β-catenin/WISP1 signaling pathway after intracerebral hemorrhage in mice., PMID:34565396
Circular RNA ACTN4 promotes intrahepatic cholangiocarcinoma progression by recruiting YBX1 to initiate FZD7 transcription., PMID:34509526
Fzd7/Wnt7b signaling contributes to stemness and chemoresistance in pancreatic cancer., PMID:33934523
A novel humanized Frizzled-7-targeting antibody enhances antitumor effects of Bevacizumab against triple-negative breast cancer via blocking Wnt/β-catenin signaling pathway., PMID:33436039
Heat-stable enterotoxin inhibits intestinal stem cell expansion to disrupt the intestinal integrity by downregulating the Wnt/β-catenin pathway., PMID:33373490
Selective activation of FZD7 promotes mesendodermal differentiation of human pluripotent stem cells., PMID:33331818
MITF functions as a tumor suppressor in non-small cell lung cancer beyond the canonically oncogenic role., PMID:33293474
Regulation of ABCG2 expression by Wnt5a through FZD7 in human pancreatic cancer cells., PMID:33200805
Frizzled-7 Identifies Platinum-Tolerant Ovarian Cancer Cells Susceptible to Ferroptosis., PMID:33172933
WNT11-FZD7-DAAM1 signalling supports tumour initiating abilities and melanoma amoeboid invasion., PMID:33082334
Non-canonical Fzd7 signaling contributes to breast cancer mesenchymal-like stemness involving Col6a1., PMID:32894152
YTHDF1 Promotes Gastric Carcinogenesis by Controlling Translation of FZD7., PMID:32788173
Concurrent Wnt pathway component expression in breast and colorectal cancer., PMID:32534708
Targeting Wnt Signaling for the Treatment of Gastric Cancer., PMID:32486243
CDDO-Me Elicits Anti-Breast Cancer Activity by Targeting LRP6 and FZD7 Receptor Complex., PMID:32015160
Expression of LGR5, FZD7, TROY, and MIST1 in Perioperatively Treated Gastric Carcinomas and Correlation with Therapy Response., PMID:31827644
Scutellarin ameliorates cartilage degeneration in osteoarthritis by inhibiting the Wnt/β-catenin and MAPK signaling pathways., PMID:31757676
Targeting Frizzled-7 Decreases Stemness and Chemotherapeutic Resistance in Gastric Cancer Cells by Suppressing Myc Expression., PMID:31733054
In Silico Identification of Potential Inhibitors of the Wnt Signaling Pathway in Human Breast Cancer., PMID:31647315
For research use only. Not for human or drug use.
