Characterization of human cytomegalovirus infection dynamics in human microglia., PMID:40299764
Human cytomegalovirus gH/gL/gO binding to PDGFRα provides a regulatory signal activating the fusion protein gB that can be blocked by neutralizing antibodies., PMID:40202318
Human cytomegalovirus gH/gL/gO binding to PDGFRα provides a regulatory signal activating the fusion protein gB that can be blocked by neutralizing antibodies., PMID:39829861
A noncanonical glycoprotein H complex enhances cytomegalovirus entry., PMID:39416215
Inhibition of human cytomegalovirus entry into mucosal epithelial cells., PMID:39074588
Human cytomegalovirus glycoprotein variants governing viral tropism and syncytium formation in epithelial cells and macrophages., PMID:38837351
Neutralization Epitopes in Trimer and Pentamer Complexes Recognized by Potent Cytomegalovirus-Neutralizing Human Monoclonal Antibodies., PMID:36342276
Polymorphic Forms of Human Cytomegalovirus Glycoprotein O Protect against Neutralization of Fibroblast Entry by Antibodies Targeting Epitopes Defined by Glycoproteins H and L., PMID:35891489
Development of broadly neutralizing antibodies targeting the cytomegalovirus subdominant antigen gH., PMID:35468974
Structural basis for HCMV Pentamer recognition by neuropilin 2 and neutralizing antibodies., PMID:35275718
In Utero Human Cytomegalovirus Infection Is Associated With Increased Levels of Putatively Protective Maternal Antibodies in Nonprimary Infection: Evidence for Boosting but Not Protection., PMID:33560335
Antibody-Independent Quantification of Cytomegalovirus Virion Protein Incorporation Using HiBiT., PMID:33555589
Immunization with Human Cytomegalovirus Core Fusion Machinery and Accessory Envelope Proteins Elicit Strong Synergistic Neutralizing Activities., PMID:32294946
Comparative neutralizing potencies of antibodies suggest conservation as well as mechanistic differences in human cytomegalovirus entry into epithelial and endothelial cells., PMID:32268919
Phase 2 Study of Anti-Human Cytomegalovirus Monoclonal Antibodies for Prophylaxis in Hematopoietic Cell Transplantation., PMID:32015031
Distribution of the CMV glycoprotein gH/gL/gO and gH/gL/pUL128/pUL130/pUL131A complex variants and associated clinical manifestations in infants infected congenitally or postnatally., PMID:31705022
Dense Bodies of a gH/gL/UL128/UL130/UL131 Pentamer-Repaired Towne Strain of Human Cytomegalovirus Induce an Enhanced Neutralizing Antibody Response., PMID:31189713
Role of pentamer complex-specific and IgG subclass 3 antibodies in HCMV hyperimmunoglobulin and standard intravenous IgG preparations., PMID:30203132
Analysis of relationships between polymorphisms in the genes encoding the pentameric complex and neutralization of clinical cytomegalovirus isolates., PMID:30174240
From recognition to execution-the HCMV Pentamer from receptor binding to fusion triggering., PMID:29866439
CD147 Promotes Entry of Pentamer-Expressing Human Cytomegalovirus into Epithelial and Endothelial Cells., PMID:29739904
Neutralization of Human Cytomegalovirus Entry into Fibroblasts and Epithelial Cells., PMID:29088098
Exploiting 2A peptides to elicit potent neutralizing antibodies by a multi-subunit herpesvirus glycoprotein complex., PMID:28989096
Structural basis for potent antibody-mediated neutralization of human cytomegalovirus., PMID:28783665
Cytomegalovirus UL128 homolog mutants that form a pentameric complex produce virus with impaired epithelial and trophoblast cell tropism and altered pathogenicity in the guinea pig., PMID:28651121
Identification of a Continuous Neutralizing Epitope within UL128 of Human Cytomegalovirus., PMID:28077639
Production of Cytomegalovirus Dense Bodies by Scalable Bioprocess Methods Maintains Immunogenicity and Improves Neutralizing Antibody Titers., PMID:27581989
Characterising variation in five genetic loci of cytomegalovirus during treatment for congenital infection., PMID:27486960
A Homolog Pentameric Complex Dictates Viral Epithelial Tropism, Pathogenicity and Congenital Infection Rate in Guinea Pig Cytomegalovirus., PMID:27387220
In Vitro Characterization of Human Cytomegalovirus-Targeting Therapeutic Monoclonal Antibodies LJP538 and LJP539., PMID:27270290
A First-in-Human Study To Assess the Safety and Pharmacokinetics of Monoclonal Antibodies against Human Cytomegalovirus in Healthy Volunteers., PMID:26926639
Scanning Mutagenesis of Human Cytomegalovirus Glycoprotein gH/gL., PMID:26656708
A cytomegalovirus DNA vaccine induces antibodies that block viral entry into fibroblasts and epithelial cells., PMID:26597035
Antigenic Characterization of the HCMV gH/gL/gO and Pentamer Cell Entry Complexes Reveals Binding Sites for Potently Neutralizing Human Antibodies., PMID:26485028
Vaccine-Derived Neutralizing Antibodies to the Human Cytomegalovirus gH/gL Pentamer Potently Block Primary Cytotrophoblast Infection., PMID:26378171
Human Cytomegalovirus gH/gL/gO Promotes the Fusion Step of Entry into All Cell Types, whereas gH/gL/UL128-131 Broadens Virus Tropism through a Distinct Mechanism., PMID:26085146
Expression of the human cytomegalovirus pentamer complex for vaccine use in a CHO system., PMID:26058896
Soluble Human Cytomegalovirus gH/gL/pUL128-131 Pentameric Complex, but Not gH/gL, Inhibits Viral Entry to Epithelial Cells and Presents Dominant Native Neutralizing Epitopes., PMID:25947373
Exploiting viral natural history for vaccine development., PMID:25794555
Structural and biochemical studies of HCMV gH/gL/gO and Pentamer reveal mutually exclusive cell entry complexes., PMID:25624487
Human cytomegalovirus vaccine based on the envelope gH/gL pentamer complex., PMID:25412505
Human cytomegalovirus gH/gL/UL128/UL130/UL131A complex elicits potently neutralizing antibodies in mice., PMID:24837507
Identification by mass spectrometry and immune response analysis of guinea pig cytomegalovirus (GPCMV) pentameric complex proteins GP129, 131 and 133., PMID:24531333
Pentameric complex of viral glycoprotein H is the primary target for potent neutralization by a human cytomegalovirus vaccine., PMID:24297878
Immunization to prevent congenital cytomegalovirus infection., PMID:23954939
A vaccine based on the rhesus cytomegalovirus UL128 complex induces broadly neutralizing antibodies in rhesus macaques., PMID:23152525
Restoration of viral epithelial tropism improves immunogenicity in rabbits and rhesus macaques for a whole virion vaccine of human cytomegalovirus., PMID:23107592
Cytomegalovirus CC chemokine promotes immune cell migration., PMID:22915808
Antibodies against neutralization epitopes of human cytomegalovirus gH/gL/pUL128-130-131 complex and virus spreading may correlate with virus control in vivo., PMID:22836657
Antibodies against the gH/gL/UL128/UL130/UL131 complex comprise the majority of the anti-cytomegalovirus (anti-CMV) neutralizing antibody response in CMV hyperimmune globulin., PMID:22532696
For research use only. Not for human or drug use.
