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InVivoMAb Anti-HHV-5/HCMV Protein UL128 & UL131A Antibody (Iv0187)

Catalog #:   VVV27001 Specific References (50) DATASHEET
Host species: Human
Isotype: IgG1
Applications: FCM, Neutralization
Accession: P16837 & F5HET4
Overview

Catalog No.

VVV27001

Species reactivity

Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5), Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5)

Host species

Human

Isotype

IgG1

Clonality

Monoclonal

Target

Uncharacterized protein UL128, UL128, Protein UL131A, UL131A

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P16837 & F5HET4

Applications

FCM, Neutralization

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Clone ID

Iv0187

Data Image
References

Characterization of human cytomegalovirus infection dynamics in human microglia., PMID:40299764

Human cytomegalovirus gH/gL/gO binding to PDGFRα provides a regulatory signal activating the fusion protein gB that can be blocked by neutralizing antibodies., PMID:40202318

Human cytomegalovirus gH/gL/gO binding to PDGFRα provides a regulatory signal activating the fusion protein gB that can be blocked by neutralizing antibodies., PMID:39829861

A noncanonical glycoprotein H complex enhances cytomegalovirus entry., PMID:39416215

The Pentamer glycoprotein complex inhibits viral Immediate Early transcription during Human Cytomegalovirus infections., PMID:39292744

Mouse cytomegalovirus lacking sgg1 shows reduced import into the salivary glands., PMID:39093048

Inhibition of human cytomegalovirus entry into mucosal epithelial cells., PMID:39074588

Human cytomegalovirus glycoprotein variants governing viral tropism and syncytium formation in epithelial cells and macrophages., PMID:38837351

Dissecting the cytomegalovirus CC chemokine: Chemokine activity and gHgLchemokine-dependent cell tropism are independent players in CMV infection., PMID:38064525

Generation of UL128-shRNA transduced fibroblasts for the release of cell-free virus from clinical human cytomegalovirus isolates., PMID:37846844

Neutralization Epitopes in Trimer and Pentamer Complexes Recognized by Potent Cytomegalovirus-Neutralizing Human Monoclonal Antibodies., PMID:36342276

Polymorphic Forms of Human Cytomegalovirus Glycoprotein O Protect against Neutralization of Fibroblast Entry by Antibodies Targeting Epitopes Defined by Glycoproteins H and L., PMID:35891489

Combined knockdown of RL13 and UL128 for release of cell-free infectivity from recent HCMV isolates., PMID:35526667

Identification of functionally important domains of human cytomegalovirus gO that act after trimer binding to receptors., PMID:35452493

Structural basis for HCMV Pentamer recognition by neuropilin 2 and neutralizing antibodies., PMID:35275718

Engineering, decoding and systems-level characterization of chimpanzee cytomegalovirus., PMID:34982803

Inclusion of the Guinea Pig Cytomegalovirus Pentameric Complex in a Live Virus Vaccine Aids Efficacy against Congenital Infection but Is Not Essential for Improving Maternal and Neonatal Outcomes., PMID:34960639

Mutagenesis of Human Cytomegalovirus Glycoprotein L Disproportionately Disrupts gH/gL/gO over gH/gL/pUL128-131., PMID:34132577

Murine Cytomegalovirus MCK-2 Facilitates In Vivo Infection Transfer from Dendritic Cells to Salivary Gland Acinar Cells., PMID:34132572

Genome sequences of human cytomegalovirus strain TB40/E variants propagated in fibroblasts and epithelial cells., PMID:34082757

The Human Cytomegalovirus Protein UL116 Interacts with the Viral Endoplasmic-Reticulum-Resident Glycoprotein UL148 and Promotes the Incorporation of gH/gL Complexes into Virions., PMID:34011552

Role of Envelope Glycoprotein Complexes in Cell-Associated Spread of Human Cytomegalovirus., PMID:33918406

The Human Cytomegalovirus UL116 Glycoprotein Is a Chaperone to Control gH-Based Complexes Levels on Virions., PMID:33889136

Cytomegaloviral determinants of CD8+ T cell programming and RhCMV/SIV vaccine efficacy., PMID:33766849

In Utero Human Cytomegalovirus Infection Is Associated With Increased Levels of Putatively Protective Maternal Antibodies in Nonprimary Infection: Evidence for Boosting but Not Protection., PMID:33560335

Antibody-Independent Quantification of Cytomegalovirus Virion Protein Incorporation Using HiBiT., PMID:33555589

Rat Cytomegalovirus Virion-Associated Proteins R131 and R129 Are Necessary for Infection of Macrophages and Dendritic Cells., PMID:33228102

The structural basis of herpesvirus entry., PMID:33087881

Association of human cytomegalovirus (HCMV) neutralizing antibodies with antibodies to the HCMV glycoprotein complexes., PMID:32746933

The power of human cytomegalovirus (HCMV) hijacked UL/b' functions lost in vitro., PMID:32551781

Influence of Human Cytomegalovirus Glycoprotein O Polymorphism on the Inhibitory Effect of Soluble Forms of Trimer- and Pentamer-Specific Entry Receptors., PMID:32350071

Specialization for Cell-Free or Cell-to-Cell Spread of BAC-Cloned Human Cytomegalovirus Strains Is Determined by Factors beyond the UL128-131 and RL13 Loci., PMID:32321807

Immunization with Human Cytomegalovirus Core Fusion Machinery and Accessory Envelope Proteins Elicit Strong Synergistic Neutralizing Activities., PMID:32294946

Comparative neutralizing potencies of antibodies suggest conservation as well as mechanistic differences in human cytomegalovirus entry into epithelial and endothelial cells., PMID:32268919

Immuno-informatics approach to design a multi-epitope vaccine to combat cytomegalovirus infection., PMID:32119992

Phase 2 Study of Anti-Human Cytomegalovirus Monoclonal Antibodies for Prophylaxis in Hematopoietic Cell Transplantation., PMID:32015031

Polymorphisms in Human Cytomegalovirus Glycoprotein O (gO) Exert Epistatic Influences on Cell-Free and Cell-to-Cell Spread and Antibody Neutralization on gH Epitopes., PMID:31996433

Differential Expression of PDGF Receptor-α in Human Placental Trophoblasts Leads to Different Entry Pathways by Human Cytomegalovirus Strains., PMID:31974453

Distribution of the CMV glycoprotein gH/gL/gO and gH/gL/pUL128/pUL130/pUL131A complex variants and associated clinical manifestations in infants infected congenitally or postnatally., PMID:31705022

Production Strategies for Pentamer-Positive Subviral Dense Bodies as a Safe Human Cytomegalovirus Vaccine., PMID:31480520

Entry of betaherpesviruses., PMID:31439151

Dense Bodies of a gH/gL/UL128/UL130/UL131 Pentamer-Repaired Towne Strain of Human Cytomegalovirus Induce an Enhanced Neutralizing Antibody Response., PMID:31189713

OR14I1 is a receptor for the human cytomegalovirus pentameric complex and defines viral epithelial cell tropism., PMID:30894498

Inclusion of Antibodies to Cell Culture Media Preserves the Integrity of Genes Encoding RL13 and the Pentameric Complex Components During Fibroblast Passage of Human Cytomegalovirus., PMID:30841507

HCMV trimer- and pentamer-specific antibodies synergize for virus neutralization but do not correlate with congenital transmission., PMID:30733288

Analysis of relationships between polymorphisms in the genes encoding the pentameric complex and neutralization of clinical cytomegalovirus isolates., PMID:30174240

The Human Cytomegalovirus Trimer and Pentamer Promote Sequential Steps in Entry into Epithelial and Endothelial Cells at Cell Surfaces and Endosomes., PMID:30111564

From recognition to execution-the HCMV Pentamer from receptor binding to fusion triggering., PMID:29866439

Expression Levels of Glycoprotein O (gO) Vary between Strains of Human Cytomegalovirus, Influencing the Assembly of gH/gL Complexes and Virion Infectivity., PMID:29743375

CD147 Promotes Entry of Pentamer-Expressing Human Cytomegalovirus into Epithelial and Endothelial Cells., PMID:29739904

Datasheet
$ 372
Product specifications
100 μg 372 1 mg 1486

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For research use only. Not for human or drug use.

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InVivoMAb Anti-HHV-5/HCMV Protein UL128 & UL131A Antibody (Iv0187) [VVV27001]
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