Catalog No.
EHG05301
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
Asp23-Gln393
Predicted molecular weight
69.76 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q05586
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
N-methyl-D-aspartate receptor subunit NR1, GluN1, Glutamate [NMDA] receptor subunit zeta-1, Glutamate receptor ionotropic, NMDA 1, NMD-R1, GRIN1, NMDAR1
Genetic aetiologies in relation to response to the ketogenic diet in 226 children with epilepsy., PMID:40290421
Dysregulated ac4C modification of mRNA in a mouse model of early-stage Alzheimer's disease., PMID:40223095
Targeted NMDA receptor knockdown in recall-activated neuronal ensembles impairs remote fear extinction., PMID:40188029
The effects of risperidone and voluntary exercise intervention on synaptic plasticity gene expressions in the hippocampus and prefrontal cortex of juvenile female rats., PMID:40096936
Bridging the gap: insights into sensorimotor deficits in NMDA receptor antibody encephalitis., PMID:40026244
Neuroprotective Effects of Myrtle Berry By-Product Extracts on 6-OHDA-Induced Cytotoxicity in PC12 Cells., PMID:39857422
Molecular scalpels dissect new GluN1 hot spots in anti-NMDA receptor encephalitis., PMID:39752539
Crocin nano-chitosan-coated compound mitigates hippocampal blood-brain barrier disruption, anxiety, and cognitive deficits in chronic immobilization stress-induced rats., PMID:39640648
Case report: Novel variants cause developmental and epileptic encephalopathy in three unrelated families from Mali., PMID:39624497
Combination of Haloperidol With UNC9994, β-arrestin-Biased Analog of Aripiprazole, Ameliorates Schizophrenia-Related Phenotypes Induced by NMDAR Deficit in Mice., PMID:39612588
Antidepressant- and Anxiolytic-Like Effect of the Froriepia subpinnata Extract in the Rat: Neurochemical Correlates., PMID:39607287
A versatile pipeline to identify convergently lost ancestral conserved fragments associated with convergent evolution of vocal learning., PMID:39581870
Differential Expression of Proteins and Genes at the Tumor-Brain Interface in Invasive Meningioma., PMID:39535842
Ligand distances as key predictors of pathogenicity and function in NMDA receptors., PMID:39535073
Motor phenotypes associated with genetic neurodevelopmental disorders., PMID:39487960
SETD2 deficiency in peripheral sensory neurons induces allodynia by promoting NMDA receptor expression through NFAT5 in rodent models., PMID:39476923
Pubertal- and Stress-Dependent Changes in Cellular Activation and Expression of Excitatory Amino Acid Receptor Subunits in the Paraventricular Nucleus of the Hypothalamus in Male and Female Rats., PMID:39467516
Establishment of human pluripotent stem cell-derived cortical neurosphere model to study pathomechanisms and chemical toxicity in Kleefstra syndrome., PMID:39343771
NMDAR1 autoantibodies as potential biomarkers for schizophrenia phenotyping., PMID:39300631
Evaluation of SK-N-SH Cells as a Model for NMDA Receptor Induced Toxicity., PMID:39215550
Foxg1 regulates translation of neocortical neuronal genes, including the main NMDA receptor subunit gene, Grin1., PMID:39183266
Progress report on new medications for seizures and epilepsy: A summary of the 17th Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XVII). II. Drugs in more advanced clinical development., PMID:39171993
Subtype-specific conformational landscape of NMDA receptor gating., PMID:39154344
Long-term saturated fat-enriched diets impair hippocampal learning and memory processes in a sex-dependent manner., PMID:39128582
RNA-sequencing reveals a shared neurotranscriptomic profile in the medial preoptic area of highly social songbirds and rats., PMID:39052331
Interplay of miRNAs and molecular pathways in spaceflight-induced depression: Insights from a rat model using simulated complex space environment., PMID:39037540
TFAP2A is involved in neuropathic pain by regulating Grin1 expression in glial cells of the dorsal root ganglion., PMID:39009095
Conditional deletion of the AMPA-GluA1 and NMDA-GluN1 receptor subunit genes in midbrain D1 neurons does not alter cocaine reward in mice., PMID:39002853
Dynamic regulation of CeA gene expression during acute and protracted abstinence from chronic binge drinking of male and female C57BL/6J mice., PMID:38945280
Targeting m6A mRNA demethylase FTO alleviates manganese-induced cognitive memory deficits in mice., PMID:38908185
Src dependency of the regulation of LTP by alternative splicing of GRIN1 exon 5., PMID:38853562
Disease-Associated Variants in GRIN1, GRIN2A and GRIN2B genes: Insights into NMDA Receptor Structure, Function, and Pathophysiology., PMID:38836461
Hippocampal proteome comparison of infant and adult Fmr1 deficiency mice reveals adult-related changes associated with postsynaptic density., PMID:38797434
Distances from ligands as main predictive features for pathogenicity and functional effect of variants in NMDA receptors., PMID:38766179
NLRP4E regulates actin cap formation through SRC and CDC42 during oocyte meiosis., PMID:38730334
Spectrum of NMDA Receptor Variants in Neurodevelopmental Disorders and Epilepsy., PMID:38727899
Neuroprotective Therapeutic Potential of microRNA-149-5p against Murine Ischemic Stroke., PMID:38573413
Altered excitatory and inhibitory ionotropic receptor subunit expression in the cortical visuospatial working memory network in schizophrenia., PMID:38548877
De novo GRIN variants in M3 helix associated with neurological disorders control channel gating of NMDA receptor., PMID:38538865
Acute Administration of HIV-1 Tat Protein Drives Glutamatergic Alterations in a Rodent Model of HIV-Associated Neurocognitive Disorders., PMID:38514527
Generation of an induced pluripotent stem cell line GWCMCi006-A from a patient with autosomal dominant neurodevelopmental disorder with or without hyperkinetic movements and seizures harboring GRIN1 c.389A > G mutation., PMID:38452705
Accumulation of NMDA receptors in accumbal neuronal ensembles mediates increased conditioned place preference for cocaine after prolonged withdrawal., PMID:38401668
L-serine treatment in patients with GRIN-related encephalopathy: a phase 2A, non-randomized study., PMID:38380699
The importance of routine genetic testing in pediatric epilepsy surgery., PMID:38366963
Dynamic regulation of CeA gene expression during acute and protracted abstinence from chronic binge drinking of male and female C57BL/6J mice., PMID:38352404
Developmental loss of NMDA receptors results in supernumerary forebrain neurons through delayed maturation of transit-amplifying neuroblasts., PMID:38336823
The mechanistic functional landscape of retinitis pigmentosa: a machine learning-driven approach to therapeutic target discovery., PMID:38321543
Behavioral and Molecular Characterization of Prenatal Stress Effects on the C57BL/6J Genetic Background for the Study of Autism Spectrum Disorder., PMID:38262736
Maf1 loss regulates spinogenesis and attenuates cognitive impairment in Alzheimer's disease., PMID:38226680
Potential mechanism of Qinggong Shoutao pill alleviating age-associated memory decline based on integration strategy., PMID:38145345
For research use only. Not for human or drug use.
