Catalog No.
YHE93201
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Lys368
Predicted molecular weight
43.88 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P52732
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
EG5, TR-interacting protein 5, Kinesin-like protein KIF11, TRIP-5, KNSL1, Kinesin-like spindle protein HKSP, TRIP5, Kinesin-related motor protein Eg5, Thyroid receptor-interacting protein 5, KIF11, Kinesin-like protein 1
Antitumor Activity of Tetrahydro-β-carboline Derivatives via Inhibition of Kinesin Spindle Protein: Validation by Molecular Docking, Molecular Dynamics, and In Vitro Assays., PMID:40508205
Gene expression network analysis identified CDK1 and KIF11 as possible key molecules in the development of colorectal cancer from normal tissues., PMID:40457491
Prepubertal exposure to 17β-estradiol downregulates motor protein genes, impairs sperm flagella formation, and reduces fertility in Nile tilapia (Oreochromis niloticus)., PMID:40412113
The Quest for Ligands Against Kinesin Motor Protein Eg5., PMID:40405485
Structure-guided development of Quinoline derivatives targeting kinesin spindle protein., PMID:40381704
The Kinesin-14 tail: Dual microtubule binding domains drive spindle morphogenesis through tight microtubule cross-linking and robust sliding., PMID:40327372
Homocapsaicin II induce ferroptosis in colorectal cancer cells via cholesterol-centrosome amplification-multipolarity axis., PMID:40319933
A comprehensive review and in silico analysis of the role of survivin (BIRC5) in hepatocellular carcinoma hallmarks: A step toward precision., PMID:40306500
TMC5 as a Marker of Tumor-Associated Telocytes in Hepatocellular Carcinoma., PMID:40302342
CDK2 inhibition produces a persistent population of polyploid cancer cells., PMID:40232858
Targeting Eg5 using Arry520 combats gastric cancer by inducing monopolar spindles., PMID:40187619
Identification of hub genes for the diagnosis and prognosis in triple negative breast cancer using transcriptome and differential methylation integration analysis., PMID:40092695
Mechanisms of Picrasma quassioides against hepatocellular carcinoma elucidated by network pharmacology and experimental validation., PMID:40092104
Integrative analysis of serum proteomics and transcriptomics in hepatitis C., PMID:40082995
KIF11 and KIF14 Are a Novel Potential Prognostic Biomarker in Patients with Endometrioid Carcinoma., PMID:40075652
Integrative analysis of T cell-mediated tumor killing-related genes reveals KIF11 as a novel therapeutic target in esophageal squamous cell carcinoma., PMID:39966857
KIF11 Inhibition Induces Retinopathy Progression by Affecting Photoreceptor Cell Ciliogenesis and Cell Cycle Regulation in Development., PMID:39957575
Gene Variant Spectrum in Probands With Familial Exudative Vitreoretinopathy Using an Expanded Panel., PMID:39918476
Integrative Bioinformatics Analysis for Targeting Hub Genes in Hepatocellular Carcinoma Treatment., PMID:39911278
Analysis and identification of potential biomarkers for dysfunctional uterine bleeding., PMID:39862473
Fragment-Based Drug Discovery of KIF11 Inhibitors for Glioblastoma Treatment: Molecular Insights and Therapeutic Potential., PMID:39842449
19S proteasome loss causes monopolar spindles through ubiquitin-independent KIF11 degradation., PMID:39829864
Maternal ELL3 loss-of-function leads to oocyte aneuploidy and early miscarriage., PMID:39820605
Insufficient MIRO1 contributes to declined oocyte quality during reproductive aging., PMID:39815032
High interstitial fluid pressure enhances USP1-dependent KIF11 protein stability to promote hepatocellular carcinoma progression., PMID:39810156
Identification and validation of the important role of KIF11 in the development and progression of endometrial cancer., PMID:39806429
Inferior sectoral chorioretinopathy in two patients with novel heterozygous KIF11 mutations., PMID:39803728
The miRNA-mRNA Regulatory Network in Human Hepatocellular Carcinoma by Transcriptomic Analysis From GEO., PMID:39764737
Identification and validation of KIF20A for predicting prognosis and treatment outcomes in patients with breast cancer., PMID:39733078
Identification of circRNA-miRNA-mRNA networks to explore underlying mechanism in lung cancer., PMID:39676897
HPV16 entry requires dynein for minus-end transport and utilizes kinesin Kif11 for plus-end transport along microtubules during mitosis., PMID:39629998
Phenotypic and Genetic Spectrum in 309 Consecutive Pediatric Patients with Inherited Retinal Disease., PMID:39596324
Exploring the Target Genes of Fucosylated Chondroitin Sulfate in Treating Lung Adenocarcinoma Based on the Integration of Bioinformatics Analysis, Molecular Docking, and Experimental Verification., PMID:39583738
Discovery of novel KSP-targeting PROTACs with potent antitumor effects in vitro and in vivo., PMID:39580911
Functional genetics reveals modulators of antimicrotubule drug sensitivity., PMID:39570287
Pan-cancer analysis of oncogenic role of CEP55 and experiment validation in clear cell renal cell carcinoma., PMID:39550427
Transport of Golgi-localized β-catenin p-S47 by KIF11 or KIFC3 induces primary ciliogenesis., PMID:39476973
Key genes and pathways in the molecular landscape of pancreatic ductal adenocarcinoma: A bioinformatics and machine learning study., PMID:39467488
KIF11 Variants Associated With Novel Renal System Involvement-Two Cases That Expand the Phenotypic Spectrum of Microcephaly With or Without Chorioretinopathy, Lymphedema, or Impaired Intellectual Development., PMID:39404449
Identification and evaluation of candidate COVID-19 critical genes and medicinal drugs related to plasma cells., PMID:39363208
A Boy With KIF11-Associated Disorder Along With ADHD and ASD: Collaboration Between Paediatrics and Child Psychiatry., PMID:39359715
Identification of exosome-related gene features in psoriasis and construction of a diagnostic model via integrated bioinformatics analysis., PMID:39358990
Integrated bioinformatic analysis reveals the gene signatures, epigenetic roles, and regulatory networks in endometriosis., PMID:39306912
Maximal clique centrality and bottleneck genes as novel biomarkers in ovarian cancer., PMID:39305503
Design and synthesis of ferrocenyl 1,4-dihydropyridines and their evaluation as kinesin-5 inhibitors., PMID:39291736
HN1 expression contributes to mitotic fidelity through Aurora A-PLK1-Eg5 axis., PMID:39291428
MG53 suppresses tumor growth via transcriptional inhibition of KIF11 in pancreatic cancer., PMID:39265509
A novel tumor-derived exosomal gene signature predicts prognosis in patients with pancreatic cancer., PMID:39262474
Transcriptomic landscape of quiescent and proliferating human corneal stromal fibroblasts., PMID:39243928
Microcephaly with or without chorioretinopathy, lymphedema, or mental retardation (MCLMR)- the new lacunae: a case report., PMID:39187757
For research use only. Not for human or drug use.
