Catalog No.
YHK17401
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gly178-Ala536
Predicted molecular weight
42.68 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q5XG87
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Non-canonical poly(A) RNA polymerase PAPD7, Topoisomerase-related function protein 4-1, Terminal nucleotidyltransferase 4A, LAK-1, TUTase 5, PAP-associated domain-containing protein 7, Terminal uridylyltransferase 5, DNA polymerase sigma, TRF4, TRF4-1, POLS, PAPD7, TENT4A, TRAMP-like complex polyadenylate polymerase, Terminal guanylyltransferase
Noncanonical Poly(A) Polymerase TENT4 Drives Expression of Subgenomic Hepatitis A Virus RNAs in Infected Cells., PMID:40431677
Widespread mono- and oligoadenylation direct small noncoding RNA maturation versus degradation fates., PMID:39975393
Biochemical analysis of the host factor activity of ZCCHC14 in hepatitis A virus replication., PMID:38501662
USB1 is a miRNA deadenylase that regulates hematopoietic development., PMID:36862787
The ZCCHC14/TENT4 complex is required for hepatitis A virus RNA synthesis., PMID:35867748
TENT4A Non-Canonical Poly(A) Polymerase Regulates DNA-Damage Tolerance via Multiple Pathways That Are Mutated in Endometrial Cancer., PMID:34203408
Host Poly(A) Polymerases PAPD5 and PAPD7 Provide Two Layers of Protection That Ensure the Integrity and Stability of Hepatitis B Virus RNA., PMID:34191584
A genome-wide CRISPR screen identifies UFMylation and TRAMP-like complexes as host factors required for hepatitis A virus infection., PMID:33730579
Chemical inhibition of PAPD5/7 rescues telomerase function and hematopoiesis in dyskeratosis congenita., PMID:32559291
Viral hijacking of the TENT4-ZCCHC14 complex protects viral RNAs via mixed tailing., PMID:32451488
A Genome-wide CRISPR Screen Identifies ZCCHC14 as a Host Factor Required for Hepatitis B Surface Antigen Production., PMID:31801065
PAPD5/7 Are Host Factors That Are Required for Hepatitis B Virus RNA Stabilization., PMID:30365161
3' RNA Uridylation in Epitranscriptomics, Gene Regulation, and Disease., PMID:30057901
Mixed tailing by TENT4A and TENT4B shields mRNA from rapid deadenylation., PMID:30026317
MicroRNP-mediated translational activation of nonadenylated mRNAs in a mammalian cell-free system., PMID:29626383
Molecular cloning and characterization of a novel isoform of the non-canonical poly(A) polymerase PAPD7., PMID:23376078
Tri-snRNP-associated proteins interact with subunits of the TRAMP and nuclear exosome complexes, linking RNA decay and pre-mRNA splicing., PMID:22336707
Air1 zinc knuckles 4 and 5 and a conserved IWRXY motif are critical for the function and integrity of the Trf4/5-Air1/2-Mtr4 polyadenylation (TRAMP) RNA quality control complex., PMID:21878619
Interaction profiling identifies the human nuclear exosome targeting complex., PMID:21855801
No evidence for shared etiology in two demyelinative disorders, MS and PLOSL., PMID:19019460
Semi-quantitative fluorescent PCR analysis identifies PRKAA1 on chromosome 5 as a potential candidate cancer gene of cervical cancer., PMID:16595147
Characterization of a multisubunit transcription factor complex essential for spliced-leader RNA gene transcription in Trypanosoma brucei., PMID:16055738
Efficient and error-free replication past a minor-groove DNA adduct by the sequential action of human DNA polymerases iota and kappa., PMID:15199127
Effects of base sequence context on translesion synthesis past a bulky (+)-trans-anti-B[a]P-N2-dG lesion catalyzed by the Y-family polymerase pol kappa., PMID:12600213
Replication-related activities establish cohesion between sister chromatids., PMID:11894848
Evidence that replication fork components catalyze establishment of cohesion between sister chromatids., PMID:11459963
[Mutagenesis by Escherichia coli DinB and its mammalian homolog Pol kappa]., PMID:11436305
Pol kappa: A DNA polymerase required for sister chromatid cohesion., PMID:10926539
The topoisomerase-related function gene TRF4 affects cellular sensitivity to the antitumor agent camptothecin., PMID:10066793
For research use only. Not for human or drug use.
