Catalog No.
EHF19201
Expression system
Insect Cells
Species
Homo sapiens (Human)
Protein length
Met1-Val220
Predicted molecular weight
24.10 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P56747
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Claudin-6, CLDN6, Skullin
Inhibition of DLK1 regulates AT2 differentiation and alleviates established pulmonary fibrosis by upregulating TTF-1/CLDN6., PMID:40380180
The Chimeric Antigen Receptor T Cell Target Claudin 6 Is a Marker for Early Organ-Specific Epithelial Progenitors and Is Expressed in Some Pediatric Solid Tumor Entities., PMID:40149257
Novel therapeutics in refractory germ cell tumors., PMID:40065678
CLDN6 triggers NRF2-mediated ferroptosis through recruiting DLG1/PBK complex in breast cancer., PMID:39984471
A mini-overview of antibody-drug conjugates in platinum-resistant ovarian cancer: A preclinical and clinical perspective., PMID:39922351
177Lu-Labeled Anticlaudin 6 Monoclonal Antibody for Targeted Therapy in Esophageal Cancer., PMID:39915118
Clinicopathological Significance of Claudin-6 Immunoreactivity in Low-grade, Early-stage Endometrioid Endometrial Carcinoma., PMID:39740870
Antibody-drug conjugates as targeted therapy for treating gynecologic cancers: update 2025., PMID:39480912
SAIL66, a next generation CLDN6-targeting T-cell engager, demonstrates potent antitumor efficacy through dual binding to CD3/CD137., PMID:39401967
NDMA enhances claudin-1 and -6 expression viaCYP2E1/ROS in AGS cells., PMID:39395750
Claudin 1, 4, 6 and 18 isoform 2 as targets for the treatment of cancer (Review)., PMID:39301632
CLDN6 inhibits breast cancer growth and metastasis through SREBP1-mediated RAS palmitoylation., PMID:39169280
Fetal gut cell-like differentiation in esophageal adenocarcinoma defines a rare tumor subtype with therapeutically relevant claudin-6 positivity and SWI/SNF gene alteration., PMID:38866822
Comprehensive landscape of junctional genes and their association with overall survival of patients with lung adenocarcinoma., PMID:38841188
Preclinical efficacy and pharmacokinetics of an RNA-encoded T cell-engaging bispecific antibody targeting human claudin 6., PMID:38776391
Tight Junction Proteins as Therapeutic Targets to Treat Liver Fibrosis and Hepatocellular Carcinoma., PMID:38648796
The Expression of the Claudin Family of Proteins in Colorectal Cancer., PMID:38540693
NK-92MI Cells Engineered with Anti-claudin-6 Chimeric Antigen Receptors in Immunotherapy for Ovarian Cancer., PMID:38481806
CLDN6 inhibited cellular biological function of nonsmall cell lung cancer cells through suppressing aerobic glycolysis via the RIP1/ASK1/JNK axis., PMID:38462752
Increased IgA-mediated responses to the gut paracellular pathway and blood-brain barrier proteins predict delirium due to hip fracture in older adults., PMID:38379706
Claudins and hepatocellular carcinoma., PMID:38185042
Systematic characterization of antibody-drug conjugate targets in central nervous system tumors., PMID:37870091
CLDN6 inhibits colorectal cancer proliferation dependent on restraining p53 ubiquitination via ZO-1/PTEN axis., PMID:37852424
Identification of key claudin genes associated with survival prognosis and diagnosis in colon cancer through integrated bioinformatic analysis., PMID:37799140
Breast-to-brain metastasis is exacerbated with chemotherapy through blood-cerebrospinal fluid barrier and induces Alzheimer's-like pathology., PMID:37787045
Binding of YY1/CREB to an Enhancer Region Triggers Claudin 6 Expression in H. pylori LPS-Stimulated AGS Cells., PMID:37762277
The tight junction protein claudin 6 is a potential target for patient-individualized treatment in esophageal and gastric adenocarcinoma and is associated with poor prognosis., PMID:37592303
Downregulation of CLDN6 inhibits cell migration and invasion and promotes apoptosis by regulation of the JAK2/STAT3 signaling pathway in hepatocellular carcinoma., PMID:37588735
CLDN6 Suppresses Migration and Invasion of MCF-7 and SKBR-3 Breast Cancer Cells by Blocking the SMAD/Snail/MMP-2/9 Axis., PMID:37566248
The Src-Family Kinases SRC and BLK Contribute to the CLDN6-Adhesion Signaling., PMID:37443730
[Advances of Claudin6-targeting drugs in cancer therapy]., PMID:37154307
PRAME and CTCFL-reactive TCRs for the treatment of ovarian cancer., PMID:37026005
Double mutation of claudin-1 and claudin-3 causes alopecia in infant mice., PMID:37002535
Targeting CLDN6 in germ cell tumors by an antibody-drug-conjugate and studying therapy resistance of yolk-sac tumors to identify and screen specific therapeutic options., PMID:36991316
CLDN6 inhibits breast cancer metastasis through WIP-dependent actin cytoskeleton-mediated autophagy., PMID:36935496
Preclinical Efficacy of the Antibody-Drug Conjugate CLDN6-23-ADC for the Treatment of CLDN6-Positive Solid Tumors., PMID:36884217
Antibody specificity against highly conserved membrane protein Claudin 6 driven by single atomic contact point., PMID:36505931
Claudin-6 enhances the malignant progression of gestational trophoblastic neoplasm by promoting proliferation and metastasis., PMID:36471225
Chromosomally Unstable Gastric Cancers Overexpressing Claudin-6 Disclose Cross-Talk between HNF1A and HNF4A, and Upregulated Cholesterol Metabolism., PMID:36430456
A single mutation in the E2 glycoprotein of hepatitis C virus broadens the claudin specificity for its infection., PMID:36424447
Target Mechanisms of the Cyanotoxin Cylindrospermopsin in Immortalized Human Airway Epithelial Cells., PMID:36422959
Knockdown of CLAUDIN-6 Inhibited Apoptosis and Induced Proliferation of Bovine Cumulus Cells., PMID:36362009
Claudin-6 increases SNAI1, NANOG and SOX2 gene expression in human gastric adenocarcinoma AGS cells., PMID:36169897
Research advance in lipid nanoparticle-mRNA delivery system and its application in CAR-T cell therapy., PMID:36161298
Claudin‑9 is a novel prognostic biomarker for endometrial cancer., PMID:36129146
Claudin 6 is associated with a short survival and a short recurrent free interval in non-small cell lung carcinoma., PMID:35848474
A phase II study assessing the safety and efficacy of ASP1650 in male patients with relapsed refractory germ cell tumors., PMID:35759134
CLDN6 inhibits breast cancer cell malignant behavior by suppressing ERK signaling., PMID:35752352
High-Frequency Irreversible Electroporation (H-FIRE) Induced Blood-Brain Barrier Disruption Is Mediated by Cytoskeletal Remodeling and Changes in Tight Junction Protein Regulation., PMID:35740406
The expression and the tumor suppressor role of CLDN6 in colon cancer., PMID:35701678
For research use only. Not for human or drug use.
