Catalog No.
YHD46801
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ser635-Gly944
Predicted molecular weight
38.30 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P21675
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
p250, TAF(II)250, CCGS, BA2R, TAF1, Transcription initiation factor TFIID subunit 1, Cell cycle gene 1 protein, TAFII-250, TAF2A, CCG1, TBP-associated factor 250 kDa, Transcription initiation factor TFIID 250 kDa subunit, TAFII250
A screen of chromatin-targeting compounds identifies TAF1 as a novel regulator of HIV latency., PMID:40475469
Histone and N-terminal acetyltransferases play important roles in female reproduction and embryogenesis of the red flour beetle Tribolium castaneum., PMID:40437965
PROTAC-Mediated Degradation of TAF1 Induces Apoptosis in AML Cells and Inhibits Tumor Growth In Vivo., PMID:40376796
Genetic insight into lung neuroendocrine tumors: Notch and Wnt signaling pathways as potential targets., PMID:40361150
Conformational and Functional Regulation of SET by Legumain Cleavage., PMID:40187686
Development and comparison of single FLT3-inhibitors to dual FLT3/TAF1-inhibitors as an anti-leukemic approach., PMID:40153395
Transcriptional activation and coactivator binding by yeast Ino2 and human proto-oncoprotein c-Myc., PMID:39820713
OSI-027 as a Potential Drug Candidate Targeting Upregulated Hub Protein TAF1 in Potential Mechanism of Sinonasal Squamous Cell Carcinoma: Insights from Proteomics and Molecular Docking., PMID:39765756
Molecular Profiling of Sinonasal Adenoid Cystic Carcinoma: Canonical and Noncanonical Gene Fusions and Mutation., PMID:39760648
Harnessing the TAF1 Acetyltransferase for Targeted Acetylation of the Tumor Suppressor p53., PMID:39716936
The roles of TAF1 in neuroscience and beyond., PMID:39323550
G-quadruplexes in an SVA retrotransposon cause aberrant TAF1 gene expression in X-linked dystonia parkinsonism., PMID:39287133
Identification and validation of coagulation and fibrinolytic-related diagnostic biomarkers for ulcerative colitis by bioinformatics analysis., PMID:39252244
Transgenerational response of germline histone acetyltransferases and deacetylases to nanoplastics at predicted environmental doses in Caenorhabditis elegans., PMID:39218082
ZNF91 is an endogenous repressor of the molecular phenotype associated with X-linked dystonia-parkinsonism (XDP)., PMID:39102544
LncR-GAS5 decrease in adenine phosphoribosyltransferase expresssion via binding TAF1 to increase kidney damage created by CIH., PMID:38994083
Mini-heterochromatin domains constrain the cis-regulatory impact of SVA transposons in human brain development and disease., PMID:38834915
Taf1 knockout is lethal in embryonic male mice and heterozygous females show weight and movement disorders., PMID:38804708
The Pseudo-Natural Product Tafbromin Selectively Targets the TAF1 Bromodomain 2., PMID:38801173
A G-quadruplex-binding platinum complex induces cancer mitochondrial dysfunction through dual-targeting mitochondrial and nuclear G4 enriched genome., PMID:38741159
[Clinical features and genetic analysis of 17 Chinese pedigrees affected with X-linked intellectual disability]., PMID:38684296
TAF1 is needed for the proliferation and maturation of thyroid follicle cells via Notch signaling., PMID:38656129
Stability of Mosaic Divergent Repeat Interruptions in X-Linked Dystonia-Parkinsonism., PMID:38616406
Therapeutic targeting of BET bromodomain and other epigenetic acetylrecognition domain-containing factors., PMID:38564841
ETS translocation variant 5 (ETV5) promotes CD4+ T cell-mediated intestinal inflammation and fibrosis in inflammatory bowel diseases., PMID:38555025
Participation of the TBP-associated factors (TAFs) in cell differentiation., PMID:38126142
A scoping review on the diagnosis and treatment of X-linked dystonia-parkinsonism., PMID:38072720
Proteomic analysis of X-linked dystonia parkinsonism disease striatal neurons reveals altered RNA metabolism and splicing., PMID:38042508
IKZF3 polymorphisms contribute to the increased risk of acute lymphoblastic leukemia in children., PMID:38018448
Ino2, activator of yeast phospholipid biosynthetic genes, interacts with basal transcription factors TFIIA and Bdf1., PMID:37947853
Deletion of taf1 and taf5 in zebrafish capitulate cardiac and craniofacial abnormalities associated with TAFopathies through perturbations in metabolism., PMID:37746814
A bioinformatics screen reveals hox and chromatin remodeling factors at the Drosophila histone locus., PMID:37735352
Taf1 N-terminal domain 2 (TAND2) of TFIID promotes formation of stable and mobile unstable TBP-TATA complexes., PMID:37716588
AMPK Associates with Chromatin and Phosphorylates the TAF-1 Subunit of the Transcription Initiation Complex to Regulate Histone Gene Expression in ALL Cells., PMID:37682252
Hierarchical TAF1-dependent co-translational assembly of the basal transcription factor TFIID., PMID:37386215
Genomic analyses in Cornelia de Lange Syndrome and related diagnoses: Novel candidate genes, genotype-phenotype correlations and common mechanisms., PMID:37377026
The Effect of Glucocorticoids on TAF1 Gene Transcription in X-linked Dystonia Parkinsonism., PMID:37234925
Tracking human neurologic disease status in mouse brain/plasma using reporter-tagged, EV-associated biomarkers., PMID:37198883
Targeting TAF1 with BAY-299 induces antitumor immunity in triple-negative breast cancer., PMID:37148745
MIAT shuttled by tumor-secreted exosomes promotes paclitaxel resistance in esophageal cancer cells by activating the TAF1/SREBF1 axis., PMID:37132394
Hierarchical TAF1-dependent co-translational assembly of the basal transcription factor TFIID., PMID:37066372
Deciphering Selectivity Mechanism of BRD9 and TAF1(2) toward Inhibitors Based on Multiple Short Molecular Dynamics Simulations and MM-GBSA Calculations., PMID:36985555
TAF1 bromodomain inhibition as a candidate epigenetic driver of congenital heart disease., PMID:36958711
Skewed X-chromosome inactivation in unsolved neurodevelopmental disease cases can guide re-evaluation For X-linked genes., PMID:36879111
The predictive value of plasma exosomal lncRNAs/mRNAs in NSCLC patients receiving immunotherapy., PMID:36801676
TFIID dependency of steady-state mRNA transcription altered epigenetically by simultaneous functional loss of Taf1 and Spt3 is Hsp104-dependent., PMID:36757926
A bioinformatics screen reveals Hox and chromatin remodeling factors at the Drosophila histone locus., PMID:36711759
Recent Advances on Small-Molecule Bromodomain-Containing Histone Acetyltransferase Inhibitors., PMID:36695774
Can molecular dynamics simulations improve predictions of protein-ligand binding affinity with machine learning?, PMID:36681903
Integrated Analysis Identifies Novel Fusion Transcripts in Laterally Spreading Tumors Suggestive of Distinct Etiology Than Colorectal Cancers., PMID:36480069
For research use only. Not for human or drug use.
