Catalog No.
YHE79101
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Leu35-Gly306
Predicted molecular weight
32.90 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P50897
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
PPT-1, Palmitoyl-protein hydrolase 1, CLN1, PPT, PPT1, Palmitoyl-protein thioesterase 1
Dual Regulation of Sprouty 4 Palmitoylation by ZDHHC7 and Palmitoyl-Protein Thioesterase 1: A Potential Therapeutic Strategy for Cisplatin-Resistant Osteosarcoma., PMID:40416361
Niemann Pick C1 mistargeting disrupts lysosomal cholesterol homeostasis contributing to neurodegeneration in a Batten disease model., PMID:40333988
Genetic Reasons for Phenotypic Diversity in Neuronal Ceroid Lipofuscinoses and High-Resolution Imaging as a Marker of Retinal Disease., PMID:40206986
Defective anterograde protein-trafficking contributes to endoplasmic reticulum-stress in a CLN1 disease model., PMID:40158736
Melatonin protects aged oocytes from depalmitoylation-mediated quality reduction by promoting PPT1 degradation and antioxidation., PMID:39862447
2024 Scholars' Research Symposium Abstract: Sex-Split Analysis of Pathology and Motor-Behavioral Outcomes in a Mouse Model Of CLN8-Batten Disease., PMID:39820909
Gene therapy ameliorates bowel dysmotility and enteric neuron degeneration and extends survival in lysosomal storage disorder mouse models., PMID:39813314
Computational exploration of palmitoyl-protein thioesterase 1 inhibition by Juniperus phoenicea L. for anti-dementia treatment., PMID:39807377
GABAAR-PPT1 palmitoylation homeostasis controls synaptic transmission and circuitry oscillation., PMID:39695089
[Study of a case of Juvenile neuronal ceroid lipofuscinosis due to compound heterozygous variants of PPT1 gene]., PMID:39653353
Haploinsufficiency of lysosomal enzyme genes in Alzheimer's disease., PMID:39605615
Enhancing Gpx1 palmitoylation to inhibit angiogenesis by targeting PPT1., PMID:39423458
Investigating PPT2's role in ovarian cancer prognosis and immunotherapy outcomes., PMID:39394143
Machine learning-aided microRNA discovery for olive oil quality., PMID:39392838
Activation of D2-like dopamine receptors improves the neuronal network and cognitive function of PPT1KI mice., PMID:39284877
Divergent effects of acute and chronic PPT1 inhibition in melanoma., PMID:39265628
Reduction of neuroinflammation and seizures in a mouse model of CLN1 batten disease using the small molecule enzyme mimetic, N-Tert-butyl hydroxylamine., PMID:39033629
Assaying Lysosomal Enzyme Activity in Dictyostelium discoideum., PMID:38954197
Akap5 links synaptic dysfunction to neuroinflammatory signaling in a mouse model of infantile neuronal ceroid lipofuscinosis., PMID:38798824
Pulsed Electric Fields Induce STING Palmitoylation and Polymerization Independently of Plasmid DNA Electrotransfer., PMID:38543257
Emerging dimensions of autophagy in melanoma., PMID:38497492
Identification of New Modulators and Inhibitors of Palmitoyl-Protein Thioesterase 1 for CLN1 Batten Disease and Cancer., PMID:38496939
PPT1 Promotes Growth and Inhibits Ferroptosis of Oral Squamous Cell Carcinoma Cells., PMID:38299399
Lucanthone, a Potential PPT1 Inhibitor, Perturbs Stemness, Reduces Tumor Microtube Formation, and Slows the Growth of Temozolomide-Resistant Gliomas In Vivo., PMID:38296645
A Semisynthesis Platform for the Efficient Production and Exploration of Didemnin-Based Drugs., PMID:38291557
Disruption of lysosomal nutrient sensing scaffold contributes to pathogenesis of a fatal neurodegenerative lysosomal storage disease., PMID:38211816
[Analysis of a child with CLN1 neuronal ceroid lipofuscinosis in conjunct with Hereditary hyperferinemia cataract syndrome]., PMID:38171563
Cyclical palmitoylation regulates TLR9 signalling and systemic autoimmunity in mice., PMID:38169466
PON1 has palmitoyl-protein thioesterase (PPT) activity, and can affect the presence of SR-B1 on the endothelial cell membrane., PMID:38135490
Ezurpimtrostat, A Palmitoyl-Protein Thioesterase-1 Inhibitor, Combined with PD-1 Inhibition Provides CD8+ Lymphocyte Repopulation in Hepatocellular Carcinoma., PMID:38133710
Advances of Protein Palmitoylation in Tumor Cell Deaths., PMID:38067206
Loss of Depalmitoylation Disrupts Homeostatic Plasticity of AMPARs in a Mouse Model of Infantile Neuronal Ceroid Lipofuscinosis., PMID:37884348
Progress on lysosomal PPT1-mediated regulation of cellular homeostasis and pathogenesis., PMID:37872111
The presence of blastocyst within the uteri facilitates lumenal epithelium transformation for implantation via upregulating lysosome proteostasis activity., PMID:37584546
Intratumoral PPT1-positive macrophages determine immunosuppressive contexture and immunotherapy response in hepatocellular carcinoma., PMID:37385725
Grain Characteristics, Moisture, and Specific Peptides Produced by Ustilaginoidea virens Contribute to False Smut Disease in Rice (Oryza sativa L.)., PMID:37189416
Identification of PPT1 as a lysosomal core gene with prognostic value in hepatocellular carcinoma., PMID:37103469
Lysosomal lipid peroxidation mediates immunogenic cell death., PMID:37066873
Characterization of heterogeneous metabolism in hepatocellular carcinoma identifies new therapeutic target and treatment strategy., PMID:37006288
Ultrasensitive Quantification Method for Understanding Biologically Relevant Concentrations of Host Cell Proteins in Therapeutics., PMID:36977129
An innovative hematopoietic stem cell gene therapy approach benefits CLN1 disease in the mouse model., PMID:36876653
Lysosomal lipid peroxidation regulates tumor immunity., PMID:36795483
Treatment of CLN1 disease with a blood-brain barrier penetrating lysosomal enzyme., PMID:36324638
Combination of Antimalarial and CNS Drugs with Antineoplastic Agents in MCF-7 Breast and HT-29 Colon Cancer Cells: Biosafety Evaluation and Mechanism of Action., PMID:36291699
Insights into ultra-low affinity lipase-antibody noncovalent complex binding mechanisms., PMID:36284469
Computational and structural investigation of Palmitoyl-Protein Thioesterase 1 (PPT1) protein causing Neuronal Ceroid Lipofuscinoses (NCL)., PMID:36088080
Cross-species efficacy of enzyme replacement therapy for CLN1 disease in mice and sheep., PMID:36040802
First-In-Human Effects of PPT1 Inhibition Using the Oral Treatment with GNS561/Ezurpimtrostat in Patients with Primary and Secondary Liver Cancers., PMID:35949290
Seizures in PPT1 Knock-In Mice Are Associated with Inflammatory Activation of Microglia., PMID:35628400
For research use only. Not for human or drug use.
