Catalog No.
YHK83501
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Cys133
Predicted molecular weight
17.22 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9H3Z4
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
DnaJ homolog subfamily C member 5, CSP, DNAJC5, Ceroid-lipofuscinosis neuronal protein 4, CLN4, Cysteine string protein
Bioinformatics-led identification of pathophysiological hallmark genes in diabesotension via graph clustering method., PMID:40491693
Uncovering the Role of the Hsp40 Family Member, Cysteine String Protein-α, in Mouse Platelets., PMID:40472286
Neuronal lipofuscinosis caused by Kufs disease/CLN4 DNAJC5 mutations but not by a CSPα/DNAJC5 deficiency., PMID:40397740
DNAJC5 facilitates the proliferation and migration of lung adenocarcinoma cells by augmenting EGFR trafficking., PMID:40374748
Comprehensive Analysis of the Role of Heat Shock Proteins in the Immune Microenvironment and Clinical Significance of Hepatocellular Carcinoma., PMID:39991516
Enhanced secretion of the amyotrophic lateral sclerosis ALS-associated misfolded TDP-43 mediated by the ER-ubiquitin specific peptidase USP19., PMID:39948244
Decoding transcriptomic signatures of cysteine string protein alpha-mediated synapse maintenance., PMID:38833477
Heat shock protein-related diagnostic signature and molecular subtypes in ankylosing spondylitis: new pathogenesis insights., PMID:38679420
Molecular subtype identification of cerebral ischemic stroke based on ferroptosis-related genes., PMID:38653998
Tissue distribution of cysteine string protein/DNAJC5 in C. elegans analysed by CRISPR/Cas9-mediated tagging of endogenous DNJ-14., PMID:38403745
LINC00624 affects hepatocellular carcinoma proliferation and apoptosis through the miR-342-3p/DNAJC5 axis., PMID:38348704
Proximity labelling reveals effects of disease-causing mutation on the DNAJC5/cysteine string protein α interactome., PMID:38193346
Decoding transcriptomic signatures of Cysteine String Protein alpha-mediated synapse maintenance., PMID:37873460
L116 Deletion in CSPα Promotes α-Synuclein Aggregation and Neurodegeneration., PMID:37566176
DNAJB8 facilitates autophagic-lysosomal degradation of viral Vif protein and restricts HIV-1 virion infectivity by rescuing APOBEC3G expression in host cells., PMID:36723955
Unconventional secretion of α-synuclein mediated by palmitoylated DNAJC5 oligomers., PMID:36626307
The roles of HSP40/DNAJ protein family in neurodegenerative diseases., PMID:36581576
Extracellular chaperone networks and the export of J-domain proteins., PMID:36581212
CSPα in neurodegenerative diseases., PMID:36466613
A Caenorhabditis elegans model of autosomal dominant adult-onset neuronal ceroid lipofuscinosis identifies ethosuximide as a potential therapeutic., PMID:36282524
Studying Unconventional Secretion of Misfolded Proteins in Cultured Cells and Primary Neurons., PMID:35819775
Safeguarding Lysosomal Homeostasis by DNAJC5/CSPα-Mediated Unconventional Protein Secretion and Endosomal Microautophagy., PMID:35620055
Abnormal triaging of misfolded proteins by adult neuronal ceroid lipofuscinosis-associated DNAJC5/CSPα mutants causes lipofuscin accumulation., PMID:35506243
Adult-Onset Neuronal Ceroid Lipofuscinosis With a Novel DNAJC5 Mutation Exhibits Aberrant Protein Palmitoylation., PMID:35462699
Analysis of protein phosphorylation sites in the hypothalamus tissues of pubescent goats., PMID:35354085
Cysteine String Protein Controls Two Routes of Export for Misfolded Huntingtin., PMID:35069097
The bacterial toxin ExoU requires a host trafficking chaperone for transportation and to induce necrosis., PMID:34188051
DNAJC5 promotes hepatocellular carcinoma cells proliferation though regulating SKP2 mediated p27 degradation., PMID:33662413
Comparative profiling of the resistance of different genotypes of mannose-binding lectin to Mycoplasma pneumoniae infection in Chinese Merino sheep based on high-throughput sequencing technology., PMID:33476923
Decrease of neuronal FKBP4/FKBP52 modulates perinuclear lysosomal positioning and MAPT/Tau behavior during MAPT/Tau-induced proteotoxic stress., PMID:33459145
Autosomal dominant neuronal ceroid lipofuscinosis: Clinical features and molecular basis., PMID:32783189
Autosomal-dominant adult neuronal ceroid lipofuscinosis caused by duplication in DNAJC5 initially missed by Sanger and whole-exome sequencing., PMID:31919451
DNAJC proteins and pathways to parkinsonism., PMID:31120186
Loss of postnatal quiescence of neural stem cells through mTOR activation upon genetic removal of cysteine string protein-α., PMID:30926666
Kufs disease due to mutation of CLN6: clinical, pathological and molecular genetic features., PMID:30561534
Modulation of Heat Shock Response Proteins by ASS234, Targeted for Neurodegenerative Diseases Therapy., PMID:30133257
Secretion of misfolded cytosolic proteins from mammalian cells is independent of chaperone-mediated autophagy., PMID:30072379
Regulation of protein homeostasis by unconventional protein secretion in mammalian cells., PMID:29549062
DNAJC5 facilitates USP19-dependent unconventional secretion of misfolded cytosolic proteins., PMID:29531792
Evidence for Cholinergic Dysfunction in Autosomal Dominant Kufs Disease., PMID:29506599
U6 snRNA expression prevents toxicity in TDP-43-knockdown cells., PMID:29125873
The Role of Co-chaperones in Synaptic Proteostasis and Neurodegenerative Disease., PMID:28579939
Gene Therapy of Adult Neuronal Ceroid Lipofuscinoses with CRISPR/Cas9 in Zebrafish., PMID:28478735
A cluster of palmitoylated cysteines are essential for aggregation of cysteine-string protein mutants that cause neuronal ceroid lipofuscinosis., PMID:28127059
Using the social amoeba Dictyostelium to study the functions of proteins linked to neuronal ceroid lipofuscinosis., PMID:27881166
DnaJ/Hsc70 chaperone complexes control the extracellular release of neurodegenerative-associated proteins., PMID:27261198
Neuronal ceroid lipofuscinosis with DNAJC5/CSPα mutation has PPT1 pathology and exhibit aberrant protein palmitoylation., PMID:26659577
Clinically early-stage CSPα mutation carrier exhibits remarkable terminal stage neuronal pathology with minimal evidence of synaptic loss., PMID:26610600
For research use only. Not for human or drug use.
