Catalog No.
YHE28801
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gly98-Gly541
Predicted molecular weight
52.54 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P41002
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
FBXO1, F-box only protein 1, Cyclin-F, CCNF, FBX1
The Molecular Intersection of NEK1, C21ORF2, Cyclin F, and VCP in ALS Pathogenesis., PMID:40282367
Exploring the Role of CCNF Variants in Italian ALS Patients., PMID:39766833
Single-cell RNA sequencing reveals the communications between tumor microenvironment components and tumor metastasis in osteosarcoma., PMID:39324133
Cyclin F-EXO1 axis controls cell cycle-dependent execution of double-strand break repair., PMID:39121215
Injury-induced Foxm1 expression in the mouse kidney drives epithelial proliferation by a cyclin F-dependent mechanism., PMID:38916959
High-content analysis of proteostasis capacity in cellular models of amyotrophic lateral sclerosis (ALS)., PMID:38879591
Genetic and clinical landscape of Chinese frontotemporal dementia: dominance of TBK1 and OPTN mutations., PMID:38872230
A Predictive Model Based on the FBXO Family Reveals the Significance of Cyclin F in Hepatocellular Carcinoma., PMID:38812312
Overexpression of cyclin F/CCNF as an independent prognostic factor for poor survival in clear cell renal cell carcinoma., PMID:38654021
Zebrafish CCNF and FUS Mediate Stress-Specific Motor Responses., PMID:38474336
ALS/FTD-associated mutation in cyclin F inhibits ER-Golgi trafficking, inducing ER stress, ERAD and Golgi fragmentation., PMID:37993492
Behavioural Variant Frontotemporal Dementia due to CCNF Gene Mutation: A Case Report., PMID:37872794
A Comprehensive Analysis of the Prognostic, Immunological and Diagnostic Role of CCNF in Pan-cancer., PMID:37670965
Free heme exacerbates colonic injury induced by anti-cancer therapy., PMID:37342339
The E3 Ubiquitin Ligase SCF Cyclin F Promotes Sequestosome-1/p62 Insolubility and Foci Formation and is Dysregulated in ALS and FTD Pathogenesis., PMID:37243816
ALS-linked CCNF variant disrupts motor neuron ubiquitin homeostasis., PMID:37220877
Accuracy of a machine learning method based on structural and locational information from AlphaFold2 for predicting the pathogenicity of TARDBP and FUS gene variants in ALS., PMID:37208601
Genetic and Phenotypic Spectrum of Amyotrophic Lateral Sclerosis Patients with CCNF Variants from a Large Chinese Cohort., PMID:37171577
CCNF is a potential pancancer biomarker and immunotherapy target., PMID:37168372
Insight into the composite assembly process, nanofibril structure and stability of undenatured type II collagen in the presence of different types of nanocelluloses., PMID:37085069
TDP-43 pathology and functional deficits in wild-type and ALS/FTD mutant cyclin F mouse models., PMID:36951214
The Skp1-Cullin1-FBXO1 complex is a pleiotropic regulator required for the formation of gametes and motile forms in Plasmodium berghei., PMID:36898988
Short-term in vivo testing to discriminate genotoxic carcinogens from non-genotoxic carcinogens and non-carcinogens using next-generation RNA sequencing, DNA microarray, and qPCR., PMID:36755350
Study of Ubiquitin Pathway Genes in a French Population with Amyotrophic Lateral Sclerosis: Focus on HECW1 Encoding the E3 Ligase NEDL1., PMID:36674783
Inhibition of Cyclin F Promotes Cellular Senescence through Cyclin-dependent Kinase 1-mediated Cell Cycle Regulation., PMID:36602672
Mutation spectrum of chinese amyotrophic lateral sclerosis patients with frontotemporal dementia., PMID:36345033
ALS-linked loss of Cyclin-F function affects HSP90., PMID:36114006
Cyclin F, Neurodegeneration, and the Pathogenesis of ALS/FTD., PMID:36062310
Recent Updates on the Genetics of Amyotrophic Lateral Sclerosis and Frontotemporal Dementia., PMID:35768750
Genetic factors for survival in amyotrophic lateral sclerosis: an integrated approach combining a systematic review, pairwise and network meta-analysis., PMID:35754054
DNA Damage, Defective DNA Repair, and Neurodegeneration in Amyotrophic Lateral Sclerosis., PMID:35572138
TDP-43 is a ubiquitylation substrate of the SCFcyclin F complex., PMID:35231559
Extracellular vesicles-derived microRNAs expression as biomarkers for neurological radiation injury: Risk assessment for space exploration., PMID:35065761
Comprehensive Analysis of Expression, Prognostic Value, and Immune Infiltration for Ubiquitination-Related FBXOs in Pancreatic Ductal Adenocarcinoma., PMID:35046938
Cyclin F drives proliferation through SCF-dependent degradation of the retinoblastoma-like tumor suppressor p130/RBL2., PMID:34851822
Increased expression of Cyclin F in liver cancer predicts poor prognosis: A study based on TCGA database., PMID:34397798
Identification of hub genes in colorectal cancer based on weighted gene co-expression network analysis and clinical data from The Cancer Genome Atlas., PMID:34308980
A Novel Signature of CCNF-Associated E3 Ligases Collaborate and Counter Each Other in Breast Cancer., PMID:34201347
Comprehensive Analysis of Cyclin Family Gene Expression in Colon Cancer., PMID:33996604
Unbiased Label-Free Quantitative Proteomics of Cells Expressing Amyotrophic Lateral Sclerosis (ALS) Mutations in CCNF Reveals Activation of the Apoptosis Pathway: A Workflow to Screen Pathogenic Gene Mutations., PMID:33986643
Prioritization of candidate genes for a South African family with Parkinson's disease using in-silico tools., PMID:33770142
ALS/FTD-causing mutation in cyclin F causes the dysregulation of SFPQ., PMID:33729478
Expression of Genomic Instability-Related Molecules: Cyclin F, RRM2 and SPDL1 and Their Prognostic Significance in Pancreatic Adenocarcinoma., PMID:33670609
Dysregulations of Expression of Genes of the Ubiquitin/SUMO Pathways in an In Vitro Model of Amyotrophic Lateral Sclerosis Combining Oxidative Stress and SOD1 Gene Mutation., PMID:33670299
Trimethylamine N-oxide mediated Y-box binding protein-1 nuclear translocation promotes cell cycle progression by directly downregulating Gadd45a expression in a cellular model of chronic kidney disease., PMID:33556375
Comprehensive Analysis of Differently Expressed and Methylated Genes in Preeclampsia., PMID:33204297
Sirtuin 5 Is Regulated by the SCFCyclin F Ubiquitin Ligase and Is Involved in Cell Cycle Control., PMID:33168699
circRNA circ-MYBL2 is a novel tumor suppressor and potential biomarker in multiple myeloma., PMID:33058028
Potential regulatory factors in the pathogenesis of ankylosing spondylitis., PMID:33040822
Cyclin F and KIF20A, FOXM1 target genes, increase proliferation and invasion of ovarian cancer cells., PMID:32771525
For research use only. Not for human or drug use.
