Catalog No.
YHK83301
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ile101-Thr338
Predicted molecular weight
30.04 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q7Z333
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
SCAR1, ALS4, SETX, SEN1 homolog, Amyotrophic lateral sclerosis 4 protein, KIAA0625, Probable helicase senataxin, Senataxin
AIM2-Driven Inflammation in Periodontitis: Mechanisms and Systemic Implications., PMID:40463858
Developing a disease-specific accessible transcriptional signature as a biomarker for ataxia with oculomotor apraxia type 2., PMID:40413398
Unveiling ten novel SETX mutations: implications for ALS pathogenesis and clinical diversity., PMID:40338003
Allele-specific silencing of a dominant SETX mutation in familial amyotrophic lateral sclerosis type 4., PMID:40200577
Senataxin prevents replicative stress induced by the Myc oncogene., PMID:40108134
Delayed diagnosis of ataxia with oculomotor apraxia type 2 in a Peruvian patient, a case report., PMID:40068357
An integrated transcriptomic analysis unveils the regulatory roles of RNA binding proteins during human spermatogenesis., PMID:40034235
SUGP1 loss is the sole driver of SF3B1 hotspot mutant missplicing in cancer., PMID:40027711
Regulation of R-Loops in DNA Tumor Viruses., PMID:39452734
Tetrameric INTS6-SOSS1 complex facilitates DNA:RNA hybrid autoregulation at double-strand breaks., PMID:39445827
Allele-specific silencing of a dominant SETX mutation in familial amyotrophic lateral sclerosis type 4., PMID:39416141
Expression, purification, and biochemical analysis of the RNA-DNA hybrid helicase Sen1/SETX from Chaetomium thermophilum., PMID:39389664
Sen1: The Varied Virtues of a Multifaceted Helicase., PMID:39357815
Obsessive-compulsive disorder as a first manifestation of Ataxia with Oculomotor Apraxia type 2 due to a novel mutation of SETX gene., PMID:39294407
R-loops and impaired autophagy trigger cGAS-dependent inflammation via micronuclei formation in Senataxin-deficient cells., PMID:39120648
Senataxin RNA/DNA helicase promotes replication restart at co-transcriptional R-loops to prevent MUS81-dependent fork degradation., PMID:39119900
Role of senataxin in R-loop-mediated neurodegeneration., PMID:39070547
Senataxin mediates R-loop resolution on HPV episomes., PMID:39046232
PELI2 is a negative regulator of STING signaling that is dynamically repressed during viral infection., PMID:38917796
Exploring the Pathogenicity of SETX I1942T Variant in Ataxia with Oculomotor Apraxia Type 2 Through Segregation Analysis., PMID:38817201
Senataxin deficiency disrupts proteostasis through nucleolar ncRNA-driven protein aggregation., PMID:38717338
Machine learning-based identification of novel hub genes associated with oxidative stress in lupus nephritis: implications for diagnosis and therapeutic targets., PMID:38637124
Genetic heterogeneity within a consanguineous family involving TTPA and SETX genes., PMID:38109176
Genetic Heterogeneity Underlying Phenotypes with Early-Onset Cerebellar Atrophy., PMID:38003592
Role of Senataxin in Amyotrophic Lateral Sclerosis., PMID:37982993
Senataxin helicase, the causal gene defect in ALS4, is a significant modifier of C9orf72 ALS G4C2 and arginine-containing dipeptide repeat toxicity., PMID:37845749
Sen1 architecture: RNA-DNA hybrid resolution, autoregulation, and insights into SETX inactivation in AOA2., PMID:37832548
New allele of mouse DNA/RNA helicase senataxin causes meiotic arrest and infertility., PMID:37801077
Helicases in R-loop Formation and Resolution., PMID:37778731
Studies of Genetic and Proteomic Risk Factors of Amyotrophic Lateral Sclerosis Inspire Biomarker Development and Gene Therapy., PMID:37566027
Proteomic profiling of the brain from the wobbler mouse model of amyotrophic lateral sclerosis reveals elevated levels of the astrogliosis marker glial fibrillary acidic protein., PMID:37565261
Senataxin: A key actor in RNA metabolism, genome integrity and neurodegeneration., PMID:37558082
Genetic Investigation of Consanguineous Pakistani Families Segregating Rare Spinocerebellar Disorders., PMID:37510308
An autopsy case of sporadic, adult-onset amyotrophic lateral sclerosis with heterozygous p.N1935S SETX gene variant., PMID:37280161
Accuracy of a machine learning method based on structural and locational information from AlphaFold2 for predicting the pathogenicity of TARDBP and FUS gene variants in ALS., PMID:37208601
Ataxia and Hypogonadism: a Review of the Associated Genes and Syndromes., PMID:36997834
In Silico Exploration of Metabolically Active Peptides as Potential Therapeutic Agents against Amyotrophic Lateral Sclerosis., PMID:36982902
DDX47 untangles R-loops with only certain other helicases., PMID:36914533
Human senataxin is a bona fide R-loop resolving enzyme and transcription termination factor., PMID:36864660
Clinical feature difference between juvenile amyotrophic lateral sclerosis with SPTLC1 and FUS mutations., PMID:36801857
Coexisting amyotrophic lateral sclerosis and chorea: A case report and literature review., PMID:36596053
A Patient with Corticobasal Syndrome and Progressive Non-Fluent Aphasia (CBS-PNFA), with Variants in ATP7B, SETX, SORL1, and FOXP1 Genes., PMID:36553628
Genetic landscape of ALS in Malta based on a quinquennial analysis., PMID:36549973
R-loop-derived cytoplasmic RNA-DNA hybrids activate an immune response., PMID:36544021
FANCD2 promotes mitotic rescue from transcription-mediated replication stress in SETX-deficient cancer cells., PMID:36543851
Genotype-phenotype characterisation of long survivors with motor neuron disease in Scotland., PMID:36515702
Ataxia with oculomotor apraxia type 2 caused by a novel homozygous mutation in SETX gene, and literature review., PMID:36438189
Transcriptional targets of senataxin and E2 promoter binding factors are associated with neuro-degenerative pathways during increased autophagic flux., PMID:36271102
For research use only. Not for human or drug use.
