Catalog No.
YHK83201
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Cys1177-Glu1258
Predicted molecular weight
37.90 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q96PY6
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
NEK1, Serine/threonine-protein kinase Nek1, Renal carcinoma antigen NY-REN-55, KIAA1901, Never in mitosis A-related kinase 1, NimA-related protein kinase 1
Mutations in NEK1 cause ciliary dysfunction as a novel pathogenic mechanism in amyotrophic lateral sclerosis., PMID:40389989
Expanding the genetic spectrum of short rib polydactyly syndrome: Novel DYNC2H1 variants and functional insights., PMID:40339774
The Molecular Intersection of NEK1, C21ORF2, Cyclin F, and VCP in ALS Pathogenesis., PMID:40282367
The low-dose CHK1 inhibitor prexasertib triggers VDAC1 dephosphorylation to activate mtDNA-STING signaling and synergize immunotherapy., PMID:40249707
A novel NEK1 variant disturbs the interaction between the C-terminal fragment of NEK1 and the VDAC1 channel, causing lethal short-rib polydactyly syndrome., PMID:40147672
MTFR1 phosphorylation-activated adaptive mitochondrial fusion is essential for colon cancer cell survival during glucose deprivation., PMID:40121946
Targeting NEK Kinases in Gastrointestinal Cancers: Insights into Gene Expression, Function, and Inhibitors., PMID:40076620
Plasmodium NEK1 coordinates MTOC organisation and kinetochore attachment during rapid mitosis in male gamete formation., PMID:39255311
ALS-associated C21ORF2 variant disrupts DNA damage repair, mitochondrial metabolism, neuronal excitability and NEK1 levels in human motor neurons., PMID:39227882
NEK1 haploinsufficiency worsens DNA damage, but not defective ciliogenesis, in C9ORF72 patient-derived iPSC-motoneurons., PMID:39222049
HDAC8 Enhances the Function of HIF-2α by Deacetylating ETS1 to Decrease the Sensitivity of TKIs in ccRCC., PMID:39073752
Association between NEK1 gene polymorphisms and the potential risk of sporadic Parkinson's disease in the Chinese Northern Han population: A case-control study., PMID:39032803
Prognostic value and immune infiltration of the NEK family in clear cell renal cell carcinoma., PMID:39029088
Clinicopathological analysis of NEK1 variants in amyotrophic lateral sclerosis., PMID:38986433
Clinical and genetic characteristics of 1672 cases of amyotrophic lateral sclerosis in China: a single-center retrospective study., PMID:38896262
Genotypes and phenotypes of motor neuron disease: an update of the genetic landscape in Scotland., PMID:38852112
Prognostic value and therapeutic potential of NEK family in stomach adenocarcinoma., PMID:38706902
Reanalysis of Whole-Exome Sequencing Data of an Infant with Suspected Diagnosis of Jeune Syndrome Revealed a Likely Pathogenic Variant in GRK2: A Newly Associated Gene for Jeune Syndrome Phenotype., PMID:38585547
The Mitochondrial Connection: The Nek Kinases' New Functional Axis in Mitochondrial Homeostasis., PMID:38534317
Genetics screening in an Italian cohort of patients with Amyotrophic Lateral Sclerosis: the importance of early testing and its implication., PMID:38112783
Genetic testing and diagnostic strategies of fetal skeletal dysplasia: a preliminary study in Wuhan, China., PMID:37875969
Genetic overlap between ALS and other neurodegenerative or neuromuscular disorders., PMID:37849306
Differential Expression of NEK Kinase Family Members in Esophageal Adenocarcinoma and Barrett's Esophagus., PMID:37835513
Loss of function of the ALS-associated NEK1 kinase disrupts microtubule homeostasis and nuclear import., PMID:37585529
Studies of Genetic and Proteomic Risk Factors of Amyotrophic Lateral Sclerosis Inspire Biomarker Development and Gene Therapy., PMID:37566027
Targeting Prostate Cancer, the 'Tousled Way'., PMID:37446279
Functional characterization of C21ORF2 association with the NEK1 kinase mutated in human in diseases., PMID:37188479
Advantages of routine next-generation sequencing over standard genetic testing in the amyotrophic lateral sclerosis clinic., PMID:37159497
Conserved NIMA kinases regulate multiple steps of endocytic trafficking., PMID:37099601
NEK Family Review and Correlations with Patient Survival Outcomes in Various Cancer Types., PMID:37046733
Genetic variability in sporadic amyotrophic lateral sclerosis., PMID:37043475
In Silico Exploration of Metabolically Active Peptides as Potential Therapeutic Agents against Amyotrophic Lateral Sclerosis., PMID:36982902
Genetic and clinical characteristics of ALS patients with NEK1 gene variants., PMID:36443167
A case of siblings with juvenile retinitis pigmentosa associated with NEK1 gene variants., PMID:36341712
Recent Updates on the Genetics of Amyotrophic Lateral Sclerosis and Frontotemporal Dementia., PMID:35768750
Genetic factors for survival in amyotrophic lateral sclerosis: an integrated approach combining a systematic review, pairwise and network meta-analysis., PMID:35754054
NEK1 and STMN2 short tandem repeat lengths are not associated with Australian amyotrophic lateral sclerosis risk., PMID:35613520
DNA Damage, Defective DNA Repair, and Neurodegeneration in Amyotrophic Lateral Sclerosis., PMID:35572138
In Mitosis You Are Not: The NIMA Family of Kinases in Aspergillus, Yeast, and Mammals., PMID:35409400
Integrative Analysis of the Expression Levels and Prognostic Values for NEK Family Members in Breast Cancer., PMID:35368696
Population-based targeted RNA sequencing reveals novel disease-related gene fusions in pediatric and adult T-ALL., PMID:35339799
Involvement of muscle satellite cell dysfunction in neuromuscular disorders: Expanding the portfolio of satellite cell-opathies., PMID:35302338
Nek1-inhibitor and temozolomide-loaded microfibers as a co-therapy strategy for glioblastoma treatment., PMID:35202726
Analysis of the effect of NEKs on the prognosis of patients with non-small-cell lung carcinoma based on bioinformatics., PMID:35105934
LINC00883 Promotes Drug Resistance of Glioma Through a microRNA-136/NEK1-Dependent Mechanism., PMID:35083134
Illuminating a Dark Kinase: Structure-Guided Design, Synthesis, and Evaluation of a Potent Nek1 Inhibitor and Its Effects on the Embryonic Zebrafish Pronephros., PMID:35081715
The NEK family of serine/threonine kinases as a biomarker for cancer., PMID:35037094
Potential Prognostic Biomarkers of NIMA (Never in Mitosis, Gene A)-Related Kinase (NEK) Family Members in Breast Cancer., PMID:34834441
Alterations of DNA damage response pathway: Biomarker and therapeutic strategy for cancer immunotherapy., PMID:34729299
For research use only. Not for human or drug use.
