Catalog No.
YHG75401
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Pro599-Glu911
Predicted molecular weight
36.85 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q14203
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
p150-glued, p135, DAP-150, 150 kDa dynein-associated polypeptide, Dynactin subunit 1, DCTN1, DP-150
The genetics of motor neuron disease in New Zealand., PMID:40424855
Dynactin subunit 1 facilitates mast cell degranulation to drive food allergy pathogenesis., PMID:40404107
Identification of Novel Biomarkers Related to Vesicle Trafficking in Alzheimer's Disease Using Bioinformatics Approaches., PMID:40338387
Activation of DCTN1-RET Fusion Through Coiled-coil Domain as a Potential Target for RET Inhibitors., PMID:40155036
Protein molecular structures of USP53, NPY2R, and DCTN1-AS1 and impact on tumors: Analysis of prognostic biomarkers for diffuse large B-cell lymphoma., PMID:39818376
TDP-43 Cryptic RNAs in Perry Syndrome: Differences across Brain Regions and TDP-43 Proteinopathies., PMID:39788898
PLK2 disrupts autophagic flux to promote SNCA/α-synuclein pathology., PMID:39773002
An Inflammatory Myofibroblastic Tumor With a Novel ALKV1180L Mutation Leading to Acquired Resistance to Tyrosine Kinase Inhibitors., PMID:39565115
Dynactin-1 mediates rescue of impaired axonal transport due to reduced mitochondrial bioenergetics in amyotrophic lateral sclerosis motor neurons., PMID:39440303
Multisystem ALK-Positive Histiocytosis With DCTN1::ALK Fusion in an Adult, Responsive to Alectinib: Case Report and Literature Review., PMID:39403984
Clinical and neurophysiological characterization of p.Gly59Ser mutation in DCTN1: a study in a Thai family and a brief review., PMID:39395070
Epithelioid Fibrous Histiocytoma Is on a Continuum With Superficial ALK -rearranged Myxoid Spindle Cell Neoplasm : A Clinicopathologic Series of 35 Cases Including Alternate RET and NTRK3 Fusions., PMID:39329254
First family with Perry syndrome from Mexico., PMID:38978535
Spitz Melanoma With SLC20A1::ALK Fusion: A Novel Fusion Previously Undescribed in Spitz Melanocytic Neoplasm., PMID:38941542
The CCTδ subunit of the molecular chaperone CCT is required for correct localisation of p150Glued to spindle poles during mitosis., PMID:38897036
ALK-rearranged, CD34-positive spindle cell neoplasms resembling dermatofibrosarcoma protuberans: a study of seven cases., PMID:38867577
Whole-exome sequencing in a cohort of Chinese patients with isolated cervical dystonia., PMID:38845987
Genetic Screening of Patients with Sporadic Alzheimer's Disease and Frontotemporal Lobar Degeneration in the Chinese Population., PMID:38701145
Comprehensive analysis indicated that NDE1 is a potential biomarker for pan-cancer and promotes bladder cancer progression., PMID:38466053
BAG5 regulates HSPA8-mediated protein folding required for sperm head-tail coupling apparatus assembly., PMID:38454159
Swedish Alzheimer's disease variant perturbs activity of retrograde molecular motors and causes widespread derangement of axonal transport pathways., PMID:38447793
Spitz melanocytic neoplasms with MLPH::ALK fusions: Report of two cases with previously unreported features and literature review., PMID:38444194
Dysregulation of stress granule dynamics by DCTN1 deficiency exacerbates TDP-43 pathology in Drosophila models of ALS/FTD., PMID:38311779
Wild-Type DCTN1 Suppresses the Aggregation of DCTN1 Mutants Associated with Perry Disease., PMID:38267040
Perry Disease: Bench to Bedside Circulation and a Team Approach., PMID:38255218
Simple models to understand complex disease: 10 years of progress from Caenorhabditis elegans models of amyotrophic lateral sclerosis and frontotemporal lobar degeneration., PMID:38239833
Sophora tonkinensis and active compounds inhibit mitochondrial impairments, inflammation, and LDLR deficiency in myocardial ischemia mice through regulating the vesicle-mediated transport pathway., PMID:38007052
Proximity extension assay-based discovery of biomarkers for disease activity in chronic inflammatory demyelinating polyneuropathy., PMID:37879899
YTHDF2 facilitates aggresome formation via UPF1 in an m6A-independent manner., PMID:37803021
A novel DCTN1 mutation causing perry syndrome leads to abnormal splicing of mRNA: genetic and functional analyses., PMID:37668947
Perry Disease: Expanding the Genetic Basis., PMID:37476320
Aging Differentially Affects Axonal Autophagosome Formation and Maturation., PMID:37464898
Reduced levels of ALS gene DCTN1 induce motor defects in Drosophila., PMID:37360176
Perry syndrome: Novel DCTN1 mutation in a large kindred and first observation of prodromal disease., PMID:37336025
Comprehensive genetic screening of early-onset dementia patients in an Austrian cohort-suggesting new disease-contributing genes., PMID:37330543
Accuracy of a machine learning method based on structural and locational information from AlphaFold2 for predicting the pathogenicity of TARDBP and FUS gene variants in ALS., PMID:37208601
Multisystem ALK-positive histiocytosis: a multi-case study and literature review., PMID:36915094
Opsin 3 mediates UVA-induced keratinocyte supranuclear melanin cap formation., PMID:36869204
Bioinformatics and Next-Generation Data Analysis for Identification of Genes and Molecular Pathways Involved in Subjects with Diabetes and Obesity., PMID:36837510
Clinical feature difference between juvenile amyotrophic lateral sclerosis with SPTLC1 and FUS mutations., PMID:36801857
ALK Amplification and Rearrangements Are Recurrent Targetable Events in Congenital and Adult Glioblastoma., PMID:36780194
Whole-exome sequencing and bioinformatic analyses revealed differences in gene mutation profiles in papillary thyroid cancer patients with and without benign thyroid goitre background., PMID:36686473
A Chinese pedigree with Perry disease caused by the p.Y78H mutation in DCTN1: A 6-year clinical follow-up., PMID:36608707
Changes on proteomic and metabolomic profiling of cryopreserved sperm effected by melatonin., PMID:36538967
Extubation failure due to atypical parkinsonism with negligible motor and variable non-motor symptoms associated with a variant of DCTN1., PMID:36504048
[A novel mutation of SPAST gene in a hereditary spastic paraplegia type 4 family]., PMID:36456515
[Genetic distribution in Chinese patients with hereditary peripheral neuropathy]., PMID:36241230
ALK-rearranged Mesenchymal Neoplasms: A Report of 9 cases Further Expanding the Clinicopathologic Spectrum of Emerging Kinase Fusion Positive Group of Tumors., PMID:36125853
HTT (huntingtin) and RAB7 co-migrate retrogradely on a signaling LAMP1-containing late endosome during axonal injury., PMID:36048753
For research use only. Not for human or drug use.
