Catalog No.
YHK83001
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Pro12-Lys83
Predicted molecular weight
36.38 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9NRR5
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
A1Up, Connexin43-interacting protein of 75 kDa, CIP75, C1orf6, UBIN, Ataxin-1 ubiquitin-like-interacting protein A1U, Ataxin-1 interacting ubiquitin-like protein, UBQLN4, Ubiquilin-4
Identification of the hub genes involved in ATF5 mediated stress response in vitrified mouse oocytes based on WGCNA., PMID:40409046
Inhibiting SNX14 Alleviates Epileptic Seizures by Regulating GluA2 Degradation via the Lysosomal Pathway., PMID:40237949
Prediction of acute myeloid leukemia prognosis based on autophagy features and characterization of its immune microenvironment., PMID:39650664
UBQLN4 promotes the proliferation and invasion of non-small cell lung cancer cell by regulating PI3K/AKT pathway., PMID:38969831
Circ_0000006 and circ_0000160 regulate hsa-let-7e-5p/UBQLN4 axis in aortic dissection progression., PMID:38820386
Short disordered termini and proline-rich domain are major regulators of UBQLN1/2/4 phase separation., PMID:38041404
Short N-terminal disordered regions and the proline-rich domain are major regulators of phase transitions for full-length UBQLN1, UBQLN2 and UBQLN4., PMID:37808720
Ubiquilin-4 induces immune escape in gastric cancer by activating the notch signaling pathway., PMID:37702916
UBQLN Family Members Regulate MYC in Lung Adenocarcinoma Cells., PMID:37444499
Genomic Amplification of UBQLN4 Is a Prognostic and Treatment Resistance Factor., PMID:36291176
UBQLN4 promotes STING proteasomal degradation during cisplatin-induced DNA damage in triple-negative breast cancer., PMID:35839317
Albendazole induces immunotherapy response by facilitating ubiquitin-mediated PD-L1 degradation., PMID:35577504
RTL8 promotes nuclear localization of UBQLN2 to subnuclear compartments associated with protein quality control., PMID:35247097
The Cyanotoxin 2,4-DAB Reduces Viability and Causes Behavioral and Molecular Dysfunctions Associated with Neurodegeneration in Larval Zebrafish., PMID:35029765
UBQLN4 is activated by C/EBPβ and exerts oncogenic effects on colorectal cancer via the Wnt/β-catenin signaling pathway., PMID:34930912
Identification of Mutator-Derived lncRNA Signatures of Genomic Instability for Promoting the Clinical Outcome in Hepatocellular Carcinoma., PMID:34840594
HYPK coordinates degradation of polyneddylated proteins by autophagy., PMID:34836490
Genome Instability-Related miRNAs Predict Survival, Immune Landscape, and Immunotherapy Responses in Gastric Cancer., PMID:34761007
ER expression associates with poor prognosis in male lung squamous carcinoma after radical resection., PMID:34548052
A Comprehensive Multiomics Analysis Identified Ubiquilin 4 as a Promising Prognostic Biomarker of Immune-Related Therapy in Pan-Cancer., PMID:34539785
UBQLN4 is an ATM substrate that stabilizes the anti-apoptotic proteins BCL2A1 and BCL2L10 in mesothelioma., PMID:34245648
Regulation of MRE11A by UBQLN4 leads to cisplatin resistance in patients with esophageal squamous cell carcinoma., PMID:33605536
Shared and divergent phase separation and aggregation properties of brain-expressed ubiquilins., PMID:33431932
Angiogenesis-Centered Molecular Cross-Talk in Amyotrophic Lateral Sclerosis Survival: Mechanistic Insights., PMID:32558493
Ubqln4 Facilitates Endoplasmic Reticulum-to-Cytosol Escape of a Nonenveloped Virus during Infection., PMID:32161173
Ubiquilins regulate autophagic flux through mTOR signalling and lysosomal acidification., PMID:30804504
UBQLN4 Represses Homologous Recombination and Is Overexpressed in Aggressive Tumors., PMID:30612738
Tryptophan 32 mediates SOD1 toxicity in a in vivo motor neuron model of ALS and is a promising target for small molecule therapeutics., PMID:30528257
The UbL-UBA Ubiquilin4 protein functions as a tumor suppressor in gastric cancer by p53-dependent and p53-independent regulation of p21., PMID:29899380
Overexpression of the Ubiquilin-4 (UBQLN4) is Associated with Cell Cycle Arrest and Apoptosis in Human Normal Gastric Epithelial Cell Lines GES-1 Cells by Activation of the ERK Signaling Pathway., PMID:29807370
Identification of differentially expressed genes in childhood asthma., PMID:29794786
Nuclear export of ubiquitinated proteins via the UBIN-POST system., PMID:29666234
Candidate genes investigation for severe nonalcoholic fatty liver disease based on bioinformatics analysis., PMID:28796060
A novel ALS-associated variant in UBQLN4 regulates motor axon morphogenesis., PMID:28463112
UBQLN4 recognizes mislocalized transmembrane domain proteins and targets these to proteasomal degradation., PMID:27113755
ATP1A3 Mutation in Adult Rapid-Onset Ataxia., PMID:26990090
Global cellular responses to β-methyl-amino-L-alanine (BMAA) by olfactory ensheathing glial cells (OEC)., PMID:25797319
Ubiquilin4 is an adaptor protein that recruits Ubiquilin1 to the autophagy machinery., PMID:23459205
Mapping of Chikungunya virus interactions with host proteins identified nsP2 as a highly connected viral component., PMID:22258240
Ubiquitin-independent proteasomal degradation of endoplasmic reticulum-localized connexin43 mediated by CIP75., PMID:20940304
Mumps virus small hydrophobic protein targets ataxin-1 ubiquitin-like interacting protein (ubiquilin 4)., PMID:20702650
A novel connexin43-interacting protein, CIP75, which belongs to the UbL-UBA protein family, regulates the turnover of connexin43., PMID:18079109
The effects of the polyglutamine repeat protein ataxin-1 on the UbL-UBA protein A1Up., PMID:15280365
Molecular cloning of a novel ubiquitin-like protein, UBIN, that binds to ER targeting signal sequences., PMID:11162551
Identification and characterization of an ataxin-1-interacting protein: A1Up, a ubiquitin-like nuclear protein., PMID:11001934
For research use only. Not for human or drug use.
