Catalog No.
YHK82901
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Lys79-Lys547
Predicted molecular weight
55.86 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9H9T3
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Elongator complex protein 3, tRNA uridine(34) acetyltransferase, Protein lysine acetyltransferase ELP3, hELP3, ELP3
Histone and N-terminal acetyltransferases play important roles in female reproduction and embryogenesis of the red flour beetle Tribolium castaneum., PMID:40437965
Serum Collagen Biomarkers Are Reflective of Tissue Specific Fibroblasts Associated With Ulcerative Colitis Activity and Treatment Response to Ustekinumab., PMID:39969502
The efficient separation of bioactive components from Eucommia ulmoides Oliver using membrane filtration technology and its mechanisms in preventing alcoholic liver disease., PMID:39779014
E4F1 coordinates pyruvate metabolism and the activity of the elongator complex to ensure translation fidelity during brain development., PMID:39747033
Elongator subunit Elp3 regulates reproduction in Tribolium castaneum by interacting with FOXO., PMID:39744885
Decoding the role of tRNA modifications in cancer progression., PMID:39088870
Loss of Elp3 blocks intestinal tuft cell differentiation via an mTORC1-Atf4 axis., PMID:39085648
Functional Characterization of the Histone Acetyltransferase FcElp3 in Lotus Rhizome Rot-Causing Fungus Fusarium commune., PMID:39007807
Genome-wide identification, phylogenetic classification of histone acetyltransferase genes, and their expression analysis in sugar beet (Beta vulgaris L.) under salt stress., PMID:38448714
Simple models to understand complex disease: 10 years of progress from Caenorhabditis elegans models of amyotrophic lateral sclerosis and frontotemporal lobar degeneration., PMID:38239833
Radiotranscriptomics of non-small cell lung carcinoma for assessing high-level clinical outcomes using a machine learning-derived multi-modal signature., PMID:38102586
Histone and Histone Acetylation-Related Alterations of Gene Expression in Uninvolved Psoriatic Skin and Their Effects on Cell Proliferation, Differentiation, and Immune Responses., PMID:37833997
ELP3 stabilizes c-Myc to promote tumorigenesis., PMID:37771073
Amyloid pathology reduces ELP3 expression and tRNA modifications leading to impaired proteostasis., PMID:37640114
Electrophoretic Mobility Shift Assay (EMSA) and Microscale Thermophoresis (MST) Methods to Measure Interactions Between tRNAs and Their Modifying Enzymes., PMID:37166655
A novel ELP1 mutation impairs the function of the Elongator complex and causes a severe neurodevelopmental phenotype., PMID:36864284
Functional Characterization of the GNAT Family Histone Acetyltransferase Elp3 and GcnE in Aspergillus fumigatus., PMID:36768506
Cryo-EM structure of the fully assembled Elongator complex., PMID:36617428
Integrative Proteomics and Transcriptomics Profiles of the Oviduct Reveal the Prolificacy-Related Candidate Biomarkers of Goats (Capra hircus) in Estrous Periods., PMID:36499219
TFEB acetylation promotes lysosome biogenesis and ameliorates Alzheimer's disease-relevant phenotypes in mice., PMID:36441024
CRABP2 - A novel biomarker for high-risk endometrial cancer., PMID:36163055
A novel splice variant of Elp3/Kat9 regulates mitochondrial tRNA modification and function., PMID:36045139
Elp3-mediated codon-dependent translation promotes mTORC2 activation and regulates macrophage polarization., PMID:35920020
Relation between the circular and linear form of the Elongator Acetyltransferase Complex Subunit 3 in the progression of triple-negative breast cancer., PMID:35722999
Tumour cells are sensitised to ferroptosis via RB1CC1-mediated transcriptional reprogramming., PMID:35220675
Dicer promotes genome stability via the bromodomain transcriptional co-activator BRD4., PMID:35194019
ELP2 compound heterozygous variants associated with cortico-cerebellar atrophy, nodular heterotopia and epilepsy: Phenotype expansion and review of the literature., PMID:34653680
Role of SSD1 in Phenotypic Variation of Saccharomyces cerevisiae Strains Lacking DEG1-Dependent Pseudouridylation., PMID:34445460
Histone acetylation: a requirement for petunia floral scent., PMID:33948651
Dynamic histone acetylation in floral volatile synthesis and emission in petunia flowers., PMID:33606881
Loss of tRNA-modifying enzyme Elp3 activates a p53-dependent antitumor checkpoint in hematopoiesis., PMID:33507234
Loss of the Transfer RNA Wobble Uridine-Modifying Enzyme Elp3 Delays T Cell Cycle Entry and Impairs T Follicular Helper Cell Responses through Deregulation of Atf4., PMID:33483347
Clinical and molecular findings in a Turkish family with an ultra-rare condition, ELP2-related neurodevelopmental disorder., PMID:33393008
How Elongator Acetylates tRNA Bases., PMID:33152999
Elastin calcification in in vitro models and its prevention by MGP's N-terminal peptide., PMID:33059036
Systematic Surveys of Iron Homeostasis Mechanisms Reveal Ferritin Superfamily and Nucleotide Surveillance Regulation to be Modified by PINK1 Absence., PMID:33023155
tRNA-modifying enzyme mutations induce codon-specific mistranslation and protein aggregation in yeast., PMID:32893724
Eukaryotic life without tQCUG: the role of Elongator-dependent tRNA modifications in Dictyostelium discoideum., PMID:32609816
Hypoxia-induced acetylation of PAK1 enhances autophagy and promotes brain tumorigenesis via phosphorylating ATG5., PMID:32186433
Loss of Elongator- and KEOPS-Dependent tRNA Modifications Leads to Severe Growth Phenotypes and Protein Aggregation in Yeast., PMID:32085421
Elongator Subunit 3 (Elp3) Is Required for Zebrafish Trunk Development., PMID:32023806
ELP3 Acetyltransferase is phosphorylated and regulated by the oncogenic anaplastic lymphoma kinase (ALK)., PMID:31341009
Proteostasis is essential during cochlear development for neuron survival and hair cell polarity., PMID:31321879
Hypoxia-elevated circELP3 contributes to bladder cancer progression and cisplatin resistance., PMID:30745833
The Elongator subunit Elp3 is a non-canonical tRNA acetyltransferase., PMID:30733442
MIR sequences recruit zinc finger protein ZNF768 to expressed genes., PMID:30476274
Non-invasive profiling of protease-specific elastin turnover in lung cancer: biomarker potential., PMID:30467633
Elongator Is Required for Root Stem Cell Maintenance by Regulating SHORTROOT Transcription., PMID:30401723
Unfolded Protein Response Suppression in Yeast by Loss of tRNA Modifications., PMID:30360492
The Arabidopsis Elongator Subunit ELP3 and ELP4 Confer Resistance to Bacterial Speck in Tomato., PMID:30087688
For research use only. Not for human or drug use.
