Catalog No.
YHK82601
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ser545-Glu742
Predicted molecular weight
24.84 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q96M96
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Actin filament-binding protein frabin, ZFYVE6, FYVE, RhoGEF and PH domain-containing protein 4, FGD1-related F-actin-binding protein, FGD4, FRABP, Zinc finger FYVE domain-containing protein 6
Multi-omics profiling reveals key factors involved in Ewing sarcoma metastasis., PMID:39757762
A Novel Mutation in Frabin (FGD4) Causing a Mild Phenotype of CMT4H in an Indian Patient., PMID:38108359
The impact of single nucleotide polymorphisms on return-to-work after taxane-based chemotherapy in breast cancer., PMID:36598552
Imbalance of NRG1-ERBB2/3 signalling underlies altered myelination in Charcot-Marie-Tooth disease 4H., PMID:36314052
Integrated Analysis of Cortex Single-Cell Transcriptome and Serum Proteome Reveals the Novel Biomarkers in Alzheimer's Disease., PMID:36009085
Atorvastatin reduces IOP in ocular hypertension in vivo and suppresses ECM in trabecular meshwork perhaps via FGD4., PMID:35417030
Current profile of Charcot-Marie-Tooth disease in Africa: A systematic review., PMID:35383421
Pathology of the peripheral neuropathy Charcot-Marie-Tooth disease type 4H in Holstein Friesian cattle with a splice site mutation in FGD4., PMID:35300540
The Importance of Multiple Gene Analysis for Diagnosis and Differential Diagnosis in Charcot Marie Tooth Disease., PMID:34169998
Sibling Cases of Charcot-Marie-Tooth Disease Type 4H with a Homozygous FGD4 Mutation and Cauda Equina Thickening., PMID:34148957
Polymorphism of FGD4 and myelosuppression in patients with esophageal squamous cell carcinoma., PMID:33709789
Phase II study of eribulin in combination with gemcitabine for the treatment of patients with locally advanced or metastatic triple negative breast cancer (ERIGE trial). Clinical and pharmacogenetic results on behalf of the Gruppo Oncologico Italiano di Ricerca Clinica (GOIRC)., PMID:33399082
EPEC Recruits a Cdc42-Specific GEF, Frabin, To Facilitate PAK Activation and Host Cell Colonization., PMID:33144373
MiR-23a induced the activation of CDC42/PAK1 pathway and cell cycle arrest in human cov434 cells by targeting FGD4., PMID:32772928
Circular RNA circFGD4 suppresses gastric cancer progression via modulating miR-532-3p/APC/β-catenin signalling pathway., PMID:32633323
A Genome-Wide Screen in Mice To Identify Cell-Extrinsic Regulators of Pulmonary Metastatic Colonisation., PMID:32245826
Identification of novel pathogenic copy number variations in Charcot-Marie-Tooth disease., PMID:31852984
FGD4 (Frabin) Overexpression in Pancreatic Neuroendocrine Neoplasms., PMID:31688594
A very mild phenotype of Charcot-Marie-Tooth disease type 4H caused by two novel mutations in FGD4., PMID:31152969
Expression of FGD4 positively correlates with the aggressive phenotype of prostate cancer., PMID:30558664
Frequent genes in rare diseases: panel-based next generation sequencing to disclose causal mutations in hereditary neuropathies., PMID:28902413
A novel mutation in FGD4 causes Charcot-Marie-Tooth disease type 4H with cranial nerve involvement., PMID:28847448
A novel mutation in the FGD4 gene causing Charcot-Marie-Tooth disease., PMID:28543957
MYO6 is targeted by Salmonella virulence effectors to trigger PI3-kinase signaling and pathogen invasion into host cells., PMID:28348208
Mechanisms of Impaired Neutrophil Migration by MicroRNAs in Myelodysplastic Syndromes., PMID:28130497
Sex-specific variation in signaling pathways and gene expression patterns in human leukocytes in response to endotoxin and exercise., PMID:27832807
Genotypes of CYP2C8 and FGD4 and their association with peripheral neuropathy or early dose reduction in paclitaxel-treated breast cancer patients., PMID:27736846
The other face of miR-17-92a cluster, exhibiting tumor suppressor effects in prostate cancer., PMID:27650539
[Peroneal myoatrophy type 4H FGD4 new gene mutation in one case and literature review]., PMID:26957070
Testing of candidate single nucleotide variants associated with paclitaxel neuropathy in the trial NCCTG N08C1 (Alliance)., PMID:26763541
Charcot-Marie-Tooth Disease Type 4H Resulting from Compound Heterozygous Mutations in FGD4 from Nonconsanguineous Korean Families., PMID:26400421
Suppression of chemotaxis by SSeCKS via scaffolding of phosphoinositol phosphates and the recruitment of the Cdc42 GEF, Frabin, to the leading edge., PMID:25356636
Aluminum Nanoparticles Induce ERK and p38MAPK Activation in Rat Brain., PMID:24386518
The first Japanese case of Charcot-Marie-Tooth disease type 4H with a novel FGD4 c.837-1G>A mutation., PMID:23770104
A novel mutation in FGD4/FRABIN causes Charcot Marie Tooth disease type 4H in patients from a consanguineous Tunisian family., PMID:23550889
Molecular analysis of the genes causing recessive demyelinating Charcot-Marie-Tooth disease in Japan., PMID:23466821
p63RhoGEF-mediated formation of a single polarized lamellipodium is required for chemotactic migration in breast carcinoma cells., PMID:23380069
Myelin is dependent on the Charcot-Marie-Tooth Type 4H disease culprit protein FRABIN/FGD4 in Schwann cells., PMID:23171661
A genome-wide association study identifies novel loci for paclitaxel-induced sensory peripheral neuropathy in CALGB 40101., PMID:22843789
Two novel missense mutations in FGD4/FRABIN cause Charcot-Marie-Tooth type 4H (CMT4H)., PMID:22734899
Epstein-Barr virus-encoded LMP1 interacts with FGD4 to activate Cdc42 and thereby promote migration of nasopharyngeal carcinoma cells., PMID:22589722
Genome-wide association study of copy number variants suggests LTBP1 and FGD4 are important for alcohol drinking., PMID:22295116
[Ultrastructural lesions of axonal mitochondria in patients with childhood-onset Charcot-Marie-Tooth disease due to MFN2 mutations]., PMID:19718987
The amino acid motif L/IIxxFE defines a novel actin-binding sequence in PDZ-RhoGEF., PMID:19618964
Differential protein expression by dendritic cells from atopic and non-atopic individuals after stimulation by the major house dust mite allergen Der p 1., PMID:19494521
Further evidence that mutations in FGD4/frabin cause Charcot-Marie-Tooth disease type 4H., PMID:19332693
A novel Frabin (FGD4) nonsense mutation p.R275X associated with phenotypic variability in CMT4H., PMID:19221294
For research use only. Not for human or drug use.
