Catalog No.
YHC15201
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Leu32-Ser493
Predicted molecular weight
55.67 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P05181
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
CYP2E, 4-nitrophenol 2-hydroxylase, CYP2E1, Cytochrome P450 2E1, CYPIIE1, Cytochrome P450-J
L-Theanine Mitigates Chronic Alcoholic Intestinal Injury by Regulating Intestinal Alcohol and Linoleic-Arachidonic Acid Metabolism in Rats., PMID:40507212
2'-Fucosyllactose Modulates the Intestinal Immune Response to Gut Microbiota and Buffers Experimental Colitis in Mice: An Integrating Investigation of Colonic Proteomics and Gut Microbiota Analysis., PMID:40501496
Shenzhuo formulation ameliorates diabetic nephropathy by regulating cytochrome P450-mediated arachidonic acid metabolism., PMID:40487618
Development of a TK6-derived cell line expressing four human cytochrome P450s for genotoxicity testing., PMID:40436327
The DNA Repair Protein MGMT Protects against the Genotoxicity of N-Nitrosodimethylamine, but Not N-Nitrosodiethanolamine and N-Nitrosomethylaniline, in Human HepG2 Liver Cells with CYP2E1 Expression., PMID:40390554
A narrative review on alcohol and alimentary tract cancer with special emphasis on acetaldehyde and oxidative stress., PMID:40378880
Optimization of Hesperidin Nanoparticles as a Promising CYP2E1 and CYP3A11 Regulator in Paracetamol-Intoxicated Mice., PMID:40370238
Sugarcane Molasses Polyphenol Extract Attenuates Alcohol-Induced Chronic Liver Damage via Antioxidant, Anti-Inflammatory, and CYP2E1/Keap1/NF-κB Pathway Modulation., PMID:40362898
Gardenin A alleviates alcohol-induced oxidative stress and inflammation in HepG2 and Caco2 cells via AMPK/Nrf2 pathway., PMID:40318507
Discovery of a CYP2E1 inhibitor and its therapeutic potential in severe acute pancreatitis., PMID:40318482
Cytochrome P450 2E1 aggravates DXR-induced myocardial injury through imbalanced mitochondrial OPA1., PMID:40307912
Uncovering the Efficacy of Cinnamomum tamala Leaf Extract Against Paracetamol-Induced Hepatotoxicity in Swiss Albino Mice., PMID:40300760
Sargassum horneri extract attenuates high-dose acetaminophen-induced hepatotoxicity by enhancing the antioxidant activity and inhibiting acetaminophen activation in the mouse liver., PMID:40291109
Acetaldehyde-driven mRNA methylation and expression changes in ethanol-metabolizing enzyme genes., PMID:40252050
In vivo inhibition of CYP2E1 fails to reduce pulegone-induced liver injury in mice., PMID:40249652
The Functional Components and Hepatic Protective Mechanism of Wolfberry Vinegar by Mixed-Culture Fermentation., PMID:40238496
Roles of Oxidative Stress and Autophagy in Alcohol-Mediated Brain Damage., PMID:40227291
Human prostacyclin and thromboxane synthases: Molecular interactions, regulation, and pharmacology., PMID:40222477
The role of cytochrome P4502E1 in ethanol mediated diseases: a narrative update., PMID:40192654
Characterization of hepatic pathology during azoxymethane-induced acute liver failure., PMID:40182596
High dose acetaminophen re-polarizes CD11b+ cells in the tumor microenvironment towards an activated macrophage phenotype., PMID:40158231
Alcohol-Metabolizing Enzymes, Liver Diseases and Cancer., PMID:40157374
Magnesium isoglycyrrhizinate prevented the liver injury of acetaminophen by promoting mitochondrial biogenesis., PMID:40151340
Maternal MitoQ Treatment Is Protective Against Programmed Alterations in CYP Activity Due to Antenatal Dexamethasone., PMID:40142951
Chitosan Oligosaccharides Prevent Alcohol-Induced Liver Disease by Attenuating Inflammation and Oxidative Stress., PMID:40137320
Effects of magnolol on the liver antioxidant status in rats with diabetes., PMID:40126860
Identification of cytochrome P450 2E1 as a novel target in neuroinflammation and development of its inhibitor Q11 as a treatment strategy., PMID:40122152
Liver microsomal protein content and activity in patients with hepatocellular carcinoma and cirrhosis: implications for the in vivo prediction of individual hepatic clearance., PMID:40115928
Cytochrome P450 Enzyme-Mediated Enantioselective Biotransformation of Chiral Fungicide Tebuconazole in Earthworm., PMID:40098277
CYP2A6 suppresses hepatocellular carcinoma via inhibiting SRC/Wnt/β-Catenin pathway., PMID:40069491
Huangqi and Danshen improve the chronic nephrotoxicity of cyclosporin A by regulating lipid metabolism., PMID:40056636
Insights into CdTe quantum dots induced hepatotoxicity: Regulation of cytochromes P450 isoenzymes function in liver microsomes from in vivo and in vitro studies., PMID:40044020
Pharmacogenomics-Based Detection of Variants Involved in Pain, Anti-inflammatory and Immunomodulating Agents Pathways by Whole Exome Sequencing and Deep in Silico Investigations Revealed Novel Chemical Carcinogenesis and Cancer Risks., PMID:40026294
[Application of Human Liver Organoids for Pharmaceutical Research]., PMID:40024731
Acute Acetaminophen Hepatotoxicity And Platelet Dysfunction., PMID:40014260
Comparative study of cytochrome P450 expression in the kidneys of Lepus yarkandensis and Oryctolagus cuniculus., PMID:40011673
Repression of the ERRγ-CYP2E1 pathway by FGF4 mitigates alcohol-associated liver injury., PMID:40009617
Effects of Chronic Alcohol Intake on the Composition of the Ensemble of Drug-Metabolizing Enzymes and Transporters in the Human Liver., PMID:39997363
Protective effects of oral pharmaceutical solution of fucoxanthin against paracetamol-induced liver injury: modulation of drug-metabolizing enzymes, oxidative stress, and apoptotic pathways in rats., PMID:39992072
Quinic acid alleviates liver toxicity induced by acetaminophen in mice via anti-oxidative and anti-inflammatory effects., PMID:39985580
Role of Cytochromes P450 in Intestinal Barrier Function: Possible Involvement in the Pathogenesis of Leaky Gut Syndrome., PMID:39971825
Kehuang capsule inhibits MAPK and AKT signaling pathways to mitigate CCl4-induced acute liver injury., PMID:39958915
Genetic polymorphisms and anti-tuberculosis drug-induced liver injury: an umbrella review of the evidence., PMID:39954223
Mechanism of Regio- and Enantioselective Hydroxylation of Arachidonic Acid Catalyzed by Human CYP2E1: A Combined Molecular Dynamics and Quantum Mechanics/Molecular Mechanics Study., PMID:39932478
Effects of periconceptional ethanol on mitochondrial content and oxidative stress in maternal liver and placentas from male and female fetuses in rats., PMID:39924874
Mediterranean diet improves liver health but does not protect against azoxymethane-induced colon tumorigenesis compared to Western diet in A/J mice., PMID:39919552
Environmentally persistent free radicals stimulate CYP2E1-mediated generation of reactive oxygen species at the expense of substrate metabolism., PMID:39884817
Effects of acteoside from Cistanche tubulosa on the plasma metabolome of cancer-related fatigue mice inoculated with colon cancer cells., PMID:39872045
Scopoletin alleviates acetaminophen-induced hepatotoxicity through modulation of NLRP3 inflammasome activation and Nrf2/HMGB1/TLR4/NF-κB signaling pathway., PMID:39870009
Lactobacillus extracellular vesicles alleviate alcohol-induced liver injury in mice by regulating gut microbiota and activating the Nrf-2 signaling pathway., PMID:39865864