Catalog No.
YHG52701
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ala2-Arg77
Predicted molecular weight
37.05 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q13428
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
TCOF1, Treacher Collins syndrome protein, Treacle protein
Treacle's ability to form liquid phase condensates is essential for nucleolar fibrillar center assembly, efficient rRNA transcription and processing, and rRNA gene repair. [YHG52701]
FuHsi maintains nucleolar integrity., PMID:40435705
Novel nonsense mutation in the TCOF1 gene associated with treacher collins syndrome: A case report., PMID:40390636
Identification of novel TCOF1 mutations in Treacher Collins syndrome and their functional characterization., PMID:40240907
High-content screening identifies ganoderic acid A as a senotherapeutic to prevent cellular senescence and extend healthspan in preclinical models., PMID:40128218
NBS1 facilitates preribosomal RNA biogenesis., PMID:40067889
Deciphering TCOF1 mutations in Chinese Treacher Collins syndrome patients: insights into pathogenesis and transcriptional disruption., PMID:39920764
FOSL1 is a key regulator of a super-enhancer driving TCOF1 expression in triple-negative breast cancer., PMID:39523372
Molecular and Clinical Heterogeneity in Hungarian Patients with Treacher Collins Syndrome-Identification of Two Novel Mutations by Next-Generation Sequencing., PMID:39518953
Protein UFMylation regulates early events during ribosomal DNA-damage response., PMID:39277864
Untangling Zebrafish Genetic Annotation: Addressing Complexities and Nomenclature Issues in Orthologous Evaluation of TCOF1 and NOLC1., PMID:39269459
Apoptotic metabolites ameliorate bone aging phenotypes via TCOF1/FLVCR1-mediated mitochondrial homeostasis., PMID:39237990
Extensive protein pyrophosphorylation revealed in human cell lines., PMID:38664588
Genotype-phenotype associations in microtia: a systematic review., PMID:38594752
The transcription of the main gene associated with Treacher-Collins syndrome (TCOF1) is regulated by G-quadruplexes and cellular nucleic acid binding protein (CNBP)., PMID:38553547
A novel intronic TCOF1 pathogenic variant in a Chinese family with Treacher Collins syndrome., PMID:38500116
The intracellular interplay between galectin-1 and FGF12 in the assembly of ribosome biogenesis complex., PMID:38468333
[Diagnosis of a Chinese pedigree affected with Treacher-Collins syndrome due to a novel variant of TCOF1 gene through whole exome sequencing]., PMID:38448022
Two novel pathogenic variants in the TCOF1 found in two Chinese cases of Treacher Collins syndrome., PMID:38444283
Distinct states of nucleolar stress induced by anticancer drugs., PMID:38099650
TCOF1 promotes the colorectal cancer progression by stabilizing β-catenin., PMID:37935810
Clinical and molecular study of Egyptian patients with Treacher Collins syndrome., PMID:37646764
Pathogenic Genes for Congenital Microtia: A Bioinformatics Analysis., PMID:37643078
[TCOF1 Gene variation in Treacher Collins syndrome and evaluation of speech rehabilitation after bone bridge surgery]., PMID:37640998
Quantitative phosphoproteomics reveals molecular pathway network alterations in human early-stage primary hepatic carcinomas: potential for 3P medical approach., PMID:37605650
An evolutionarily nascent architecture underlying the formation and emergence of biomolecular condensates., PMID:37586369
Target genes of N6-methyladenosine regulatory protein ALKBH5 are associated with prognosis of patients with lung adenocarcinoma., PMID:37426138
Ribosome biosynthesis and Hedgehog activity are cooperative actionable signaling mechanisms in breast cancer following radiotherapy., PMID:37380890
Nucleolar protein treacle ribosome biogenesis factor 1 maintains gastric cancer cell proliferation by regulating R-loop associated DNA replication stress., PMID:36941105
Zoobiquity experiments show the importance of the local MMP9-plasminogen axis in inflammatory bowel diseases in both dogs and patients., PMID:36933193
Genetic mutations in ribosomal biogenesis gene TCOF1 identified in human neural tube defects., PMID:36808708
Exploration and validation of the prognostic value of RNA-binding proteins in hepatocellular carcinoma., PMID:36524514
FGF12 is a novel component of the nucleolar NOLC1/TCOF1 ribosome biogenesis complex., PMID:36411431
Establishment and verification of a prognostic model of liver cancer by RNA-binding proteins based on the TCGA database., PMID:36249884
A systematic review on Treacher Collins syndrome: Correlation between molecular genetic findings and clinical severity., PMID:36203321
Nucleolar Protein Treacle Is Important for the Efficient Growth of Mumps Virus., PMID:36135364
A Novel Missense Variant in the TCOF1 Gene in one Chinese Case With Treacher Collins Syndrome., PMID:36082953
Dynamic regulation and requirement for ribosomal RNA transcription during mammalian development., PMID:35881792
Treacle is Upregulated in Cancer and Correlates With Poor Prognosis., PMID:35794866
Treacle Sticks the Nucleolar Responses to DNA Damage Together., PMID:35646927
Prenatally diagnosed microdeletion in the TCOF1 gene in fetal congenital primary Treacher Collins Syndrome., PMID:35595448
BMPR-IB gene disruption causes severe limb deformities in pigs., PMID:35362676
The oncogenic role of treacle ribosome biogenesis factor 1 (TCOF1) in human tumors: a pan-cancer analysis., PMID:35093935
Tcof1 haploinsufficiency promotes early T cell precursor-like leukemia in NrasQ61R/+ mice., PMID:35082403
TCOF1 coordinates oncogenic activation and rRNA production and promotes tumorigenesis in HCC., PMID:34904330
Discovery of AL-GDa62 as a Potential Synthetic Lethal Lead for the Treatment of Gastric Cancer., PMID:34878770
Modulation of transcriptional mineralocorticoid receptor activity by casein kinase 1., PMID:34847273
TCOF1 upregulation in triple-negative breast cancer promotes stemness and tumour growth and correlates with poor prognosis., PMID:34718356
Phenotypic and Molecular Heterogeneity in Mandibulofacial Dysostoses: A Case Series From India., PMID:34714179
Identification of three novel TCOF1 mutations in patients with Treacher Collins Syndrome., PMID:34580285
For research use only. Not for human or drug use.
