Catalog No.
RXX11301
Expression system
Mammalian Cells
Species reactivity
Staphylococcus aureus (strain MSSA476) (Q6GA86), Staphylococcus aureus (strain bovine RF122 / ET3-1) (Q2YX96), Staphylococcus aureus (strain COL) (Q5HGV5)
Host species
Mouse
Isotype
IgG2a
Clonality
Monoclonal
Target
isdB, frpB, sasJ, sirH, Iron-regulated surface determinant protein B, Fur-regulated protein B, Staphylococcal iron-regulated protein H, Staphylococcus aureus surface protein J
Concentration
2.47 mg/ml
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q6GA86
Applications
ELISA, SPR
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
SAA1456
Pathobiont-driven antibody sialylation through IL-10 undermines vaccination., PMID:39680460
A Unique Combination of Mn2+ and Aluminum Adjuvant Acted the Synergistic Effect., PMID:38660494
The characteristics of pre-existing humoral imprint determine efficacy of S. aureus vaccines and support alternative vaccine approaches., PMID:38232694
PEI-PLGA nanoparticles significantly enhanced the immunogenicity of IsdB137-361 proteins from Staphylococcus aureus., PMID:37506158
Targeting hemoglobin receptors IsdH and IsdB of Staphylococcus aureus with a single VHH antibody inhibits bacterial growth., PMID:37330175
Anti-staphylococcus aureus adaptive immunity is impaired in end-stage renal disease patients on hemodialysis: one-year longitudinal study., PMID:37304264
Non-protective immune imprint underlies failure of Staphylococcus aureus IsdB vaccine., PMID:35803276
In silico designed Staphylococcus aureus B-cell multi-epitope vaccine did not elicit antibodies against target antigens suggesting multi-domain approach., PMID:35341759
Staphylococcus aureus iron-regulated surface determinant B (IsdB) protein interacts with von Willebrand factor and promotes adherence to endothelial cells., PMID:34815454
StaphAIR: A Label-Free Antigen Microarray Approach to Detecting Anti-Staphylococcus aureus Antibody Responses in Orthopedic Infections., PMID:34596381
IgG4-specific responses in patients with Staphylococcus aureus bone infections are not predictive of postoperative complications., PMID:34549414
Immunodominance of Epitopes and Protective Efficacy of HI Antigen Are Differentially Altered Using Different Adjuvants in a Mouse Model of Staphylococcus aureus Bacteremia., PMID:34122448
Intramammary infection caused by Staphylococcus aureus increases IgA antibodies to iron-regulated surface determinant-A, -B, and -H in bovine milk., PMID:33838543
Serum antibodies against Staphylococcus aureus can prognose treatment success in patients with bone infections., PMID:33325051
IsdB antibody-mediated sepsis following S. aureus surgical site infection., PMID:33004694
A Bioinformatic Approach to Utilize a Patient's Antibody-Secreting Cells against Staphylococcus aureus to Detect Challenging Musculoskeletal Infections., PMID:32571786
The novel combinations of CTB, CpG, and aluminum hydroxide significantly enhanced the immunogenicity of clumping factor A 221-550 of Staphylococcus aureus., PMID:32501144
Rapid and Broad Immune Efficacy of a Recombinant Five-Antigen Vaccine against Staphylococcus Aureus Infection in Animal Models., PMID:32197534
Human VH1-69 Gene-Encoded Human Monoclonal Antibodies against Staphylococcus aureus IsdB Use at Least Three Distinct Modes of Binding To Inhibit Bacterial Growth and Pathogenesis., PMID:31641091
Human mAbs to Staphylococcus aureus IsdA Provide Protection Through Both Heme-Blocking and Fc-Mediated Mechanisms., PMID:30496483
Immune response effects of diverse vaccine antigen attachment ways based on the self-made nanoemulsion adjuvant in systemic MRSA infection., PMID:35540467
Germline-encoded neutralization of a Staphylococcus aureus virulence factor by the human antibody repertoire., PMID:27857134
Protective efficacy of the chimeric Staphylococcus aureus vaccine candidate IC in sepsis and pneumonia models., PMID:26865417
Protection of mice against Staphylococcus aureus infection by a recombinant protein ClfA-IsdB-Hlg as a vaccine candidate., PMID:26155981
A Diagnostic Serum Antibody Test for Patients With Staphylococcus aureus Osteomyelitis., PMID:26013151
Cross-protective effect of a novel multi-antigen-chimeric vaccine against Streptococcus and Staphylococcus aureus infection in mice., PMID:25288644
Evaluation of the protective immunity of a novel subunit fusion vaccine in a murine model of systemic MRSA infection., PMID:24324681
Improved protective efficacy of a chimeric Staphylococcus aureus vaccine candidate iron-regulated surface determinant B ( N 126- P 361) -target of RNAIII activating protein in mice., PMID:24117875
Naturally occurring IgG antibody levels to the Staphylococcus aureus protein IsdB in humans., PMID:23778314
Opsonic and protective properties of antibodies raised to conjugate vaccines targeting six Staphylococcus aureus antigens., PMID:23077517
Characterization of the mechanism of protection mediated by CS-D7, a monoclonal antibody to Staphylococcus aureus iron regulated surface determinant B (IsdB)., PMID:22919628
Phase IIa study of the immunogenicity and safety of the novel Staphylococcus aureus vaccine V710 in adults with end-stage renal disease receiving hemodialysis., PMID:22837094
Immunization with Staphylococcus aureus iron regulated surface determinant B (IsdB) confers protection via Th17/IL17 pathway in a murine sepsis model., PMID:22327491
The immunogenicity and safety of different formulations of a novel Staphylococcus aureus vaccine (V710): results of two Phase I studies., PMID:22192849
Progress toward a Staphylococcus aureus vaccine., PMID:22186773
[Cloning and expression of Staphylococcus aureus surface protein Isdb and its immune experiment in mice]., PMID:21847990
A fully human monoclonal antibody to Staphylococcus aureus iron regulated surface determinant B (IsdB) with functional activity in vitro and in vivo., PMID:21178283
Safety and immunogenicity of a novel Staphylococcus aureus vaccine: results from the first study of the vaccine dose range in humans., PMID:20943877
Evaluation of some Staphylococcus aureus iron-regulated proteins as vaccine targets., PMID:20416953
IsdA and IsdB antibodies protect mice against Staphylococcus aureus abscess formation and lethal challenge., PMID:20226248
Direct interaction of iron-regulated surface determinant IsdB of Staphylococcus aureus with the GPIIb/IIIa receptor on platelets., PMID:20007649
Selection and characterization of murine monoclonal antibodies to Staphylococcus aureus iron-regulated surface determinant B with functional activity in vitro and in vivo., PMID:19553551
Genetic requirements for Staphylococcus aureus abscess formation and persistence in host tissues., PMID:19525403
Serologic assay to quantify human immunoglobulin G antibodies to the Staphylococcus aureus iron surface determinant B antigen., PMID:19321693
Vaccine assembly from surface proteins of Staphylococcus aureus., PMID:17075065
A novel Staphylococcus aureus vaccine: iron surface determinant B induces rapid antibody responses in rhesus macaques and specific increased survival in a murine S. aureus sepsis model., PMID:16552052
For research use only. Not for human or drug use.
