InVivoMAb Anti-Human SOD1 Antibody (AP-101)

Catalog No.

VHB86001

Species reactivity

Human

Host species

Human

Isotype

IgG1, kappa

Clonality

Monoclonal

Target

Superoxide dismutase [Cu-Zn], SOD1, hSod1, Superoxide dismutase 1

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P00441

Applications

Neutralization

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Clone ID

AP-101

Novel extracellular vesicle release pathway facilitated by toxic superoxide dismutase 1 oligomers., PMID:40291716

Hypothermia Shifts Neurodegeneration Phenotype in Neonatal Human Hypoxic-Ischemic Encephalopathy but Not in Related Piglet Models: Possible Relationship to Toxic Conformer and Intrinsically Disordered Prion-like Protein Accumulation., PMID:40277911

[Involvement of essential trace elements in the pathogenesis of thyroid diseases: diagnostic markers and analytical methods for determination]., PMID:40089880

Shear stress preconditioning enhances periodontal ligament stem cell survival., PMID:40086040

Secreted neurofilament light chain after neuronal damage induces myeloid cell activation and neuroinflammation., PMID:40056413

Enhanced Interleukin 6 Trans-Signaling Modulates Disease Process in Amyotrophic Lateral Sclerosis Mouse Models., PMID:39851451

Antibody-Based PET Imaging of Misfolded Superoxide Dismutase 1 in an Amyotrophic Lateral Sclerosis Mouse Model., PMID:39667814

Benzo (A) pyrene exposure alters alveolar epithelial and macrophage cells diversity and induces antioxidant responses in lungs., PMID:39506978

Specific analysis of SOD1 enzymatic activity in CSF from ALS patients with and without SOD1 mutations., PMID:39490682

Potential benefits of advanced chelate-based trace minerals in improving bone mineralization, antioxidant status, immunity, and gene expression modulation in heat-stressed broilers., PMID:39356694

Bisphenol A-induced oxidative stress increases the production of ovarian cancer stem cells in mice., PMID:39322090

A novel molecular target, superoxide dismutase 1, in ALK inhibitor-resistant lung cancer cells, detected through proteomic analysis., PMID:39313177

Human Placenta Extract (HPH) Suppresses Inflammatory Responses in TNF-α/IFN-γ-Stimulated HaCaT Cells and a DNCB Atopic Dermatitis (AD)-Like Mouse Model., PMID:39252632

Neutralizing Oxidized Phosphatidylcholine Reduces Airway Inflammation and Hyperreactivity in a Murine Model of Allergic Asthma., PMID:39194564

Direct observation of prion-like propagation of protein misfolding templated by pathogenic mutants., PMID:39009686

Possible pathogenic mechanisms for doxorubicin-induced splenic atrophy in a human breast cancer xenograft mouse model., PMID:38943348

MS785-MS27 Reactive Misfolded/Non-Native Zn-Deficient SOD1 Species Exhibit Cytotoxicity and Adopt Heterozygous Conformations in Motor Neurons., PMID:38891791

Synergistic Effect of Maternal Micronutrient Supplementation on ORFV DNA Vaccine Immune Response in a Pregnant Model., PMID:38874865

CCDC50 mediates the clearance of protein aggregates to prevent cellular proteotoxicity., PMID:38869076

Variability in SOD1-associated amyotrophic lateral sclerosis: geographic patterns, clinical heterogeneity, molecular alterations, and therapeutic implications., PMID:38811997

Dietary Artemisia arborescens Supplementation Effects on Growth, Oxidative Status, and Immunity of Gilthead Seabream (Sparus aurata L.)., PMID:38672308

Repurposing the diuretic benzamil as an anti-osteosarcoma agent that acts by suppressing integrin/FAK/STAT3 signalling and compromising mitochondrial function., PMID:38569602

Engineered Dual Antioxidant Enzyme Complexes Targeting ICAM-1 on Brain Endothelium Reduce Brain Injury-Associated Neuroinflammation., PMID:38534474

Tryptophan residues in TDP-43 and SOD1 modulate the cross-seeding and toxicity of SOD1., PMID:38522514

Engineering a monobody specific to monomeric Cu/Zn-superoxide dismutase associated with amyotrophic lateral sclerosis., PMID:38511674

Bovine Colostrum Supplementation in Rabbit Diet Modulates Gene Expression of Cytokines, Gut-Vascular Barrier, and Red-Ox-Related Molecules in the Gut Wall., PMID:38473185

Selective elimination of younger erythrocytes in blood circulation and associated molecular changes in benzo (a) pyrene induced mouse model of lung cancer., PMID:38178996

RGMa collapses the neuronal actin barrier against disease-implicated protein and exacerbates ALS., PMID:37992159

Identification of high-performing antibodies for Superoxide dismutase [Cu-Zn] 1 (SOD1) for use in Western blot, immunoprecipitation, and immunofluorescence., PMID:37860271

Effects of infliximab on oxidative stress and inflammation of H9c2 cells induced by H2O2., PMID:37807314

Elevated α5 integrin expression on myeloid cells in motor areas in amyotrophic lateral sclerosis is a therapeutic target., PMID:37523555

Lipid nanoparticle delivery of siRNA targeting Cyp2e1 gene attenuates subacute alcoholic liver injury in mice., PMID:37476942

Blocking an epitope of misfolded SOD1 ameliorates disease phenotype in a model of amyotrophic lateral sclerosis., PMID:37394908

β-Lapachone Exerts Anticancer Effects by Downregulating p53, Lys-Acetylated Proteins, TrkA, p38 MAPK, SOD1, Caspase-2, CD44 and NPM in Oxaliplatin-Resistant HCT116 Colorectal Cancer Cells., PMID:37373014

A novel antibody to treat SOD1-related amyotrophic lateral sclerosis., PMID:37090477

Efficacy of oligodendrocyte precursor cells as delivery vehicles for single-chain variable fragment to misfolded SOD1 in ALS rat model., PMID:36874245

Accelerated Senescence and Apoptosis in the Rat Liver during the Progression of Diabetic Complications., PMID:36818894

Anti-SOD1 Nanobodies That Stabilize Misfolded SOD1 Proteins Also Promote Neurite Outgrowth in Mutant SOD1 Human Neurons., PMID:36555655

Therapeutic tools for familial ALS., PMID:36503675

SERS "hot spot" enhance-array assay for misfolded SOD1 correlated with white matter lesions and aging., PMID:36464456

Blood Coral Polysaccharide Helps Prevent D-Gal/LPS-Induced Acute Liver Failure in Mice., PMID:35966003

Gene Therapy in Amyotrophic Lateral Sclerosis., PMID:35805149

Inhibition of myostatin and related signaling pathways for the treatment of muscle atrophy in motor neuron diseases., PMID:35727341

Accumulation of misfolded SOD1 outlines distinct patterns of motor neuron pathology and death during disease progression in a SOD1G93A mouse model of amyotrophic lateral sclerosis., PMID:35584812

Increased LCN2 (lipocalin 2) in the RPE decreases autophagy and activates inflammasome-ferroptosis processes in a mouse model of dry AMD., PMID:35473441

Involvement of muscle satellite cell dysfunction in neuromuscular disorders: Expanding the portfolio of satellite cell-opathies., PMID:35302338

Chlorovirus ATCV-1 Accelerates Motor Deterioration in SOD1-G93A Transgenic Mice and Its SOD1 Augments Induction of Inflammatory Factors From Murine Macrophages., PMID:35280283

Respiratory onset of amyotrophic lateral sclerosis in a pregnant woman with a novel SOD1 mutation., PMID:35253968

Toll-Like Receptor- and Protein Kinase R-Induced Type I Interferon Sustains Infection of Leishmania donovani in Macrophages., PMID:35154115

Superoxide Dismutase Prevents SARS-CoV-2-Induced Plasma Cell Apoptosis and Stabilizes Specific Antibody Induction., PMID:35047106

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