Catalog No.
EHA41901
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
Arg372-Phe622
Predicted molecular weight
31.83 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O15118
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
NPC intracellular cholesterol transporter 1, Niemann-Pick C1 protein, NPC1
Wisteria floribunda agglutinin enhances Zaire ebolavirus entry through interactions at specific N-linked glycosylation sites on the virus glycoprotein complex., PMID:40476860
Discovery of novel diagnostic biomarkers of hepatocellular carcinoma associated with immune infiltration., PMID:40440122
Niemann Pick C1 mistargeting disrupts lysosomal cholesterol homeostasis contributing to neurodegeneration in a Batten disease model., PMID:40333988
Causal Associations Between Lipids, NPC1L1, and Liver Cancer Risk: Insights From Mendelian Randomization and Bioinformatics., PMID:40312834
Sex-dependent upregulation in oxylipins involved in inflammation resolution in the cerebellum of Niemann-Pick disease C1 mice., PMID:40306479
ApoE4 requires lipidation enhancement to resolve cellular lipid and protein abnormalities following NPC1 inhibition., PMID:40301465
Association between lipid-lowering drug targets and the risk of cystic kidney disease: a drug-target Mendelian randomization analysis., PMID:40289090
Npc1 gene mutation impairs multilineage differentiation potential of hepatic telocytes in murine models., PMID:40257496
Mapping Immunological, Host Receptor Binding Determinants, and Cathepsin Cleavage Site of EBOV Glycoprotein Utilizing the Qubevirus Platform., PMID:40256529
Evidence of Oxytosis/Ferroptosis in Niemann-Pick Disease Type C., PMID:40243519
Effects of opium on cholesterol metabolism in rats fed normal and high-fat/high-cholesterol diet., PMID:40230514
Causal Association Between Cholesterol-Lowering Drugs and Diabetic Microvascular Complications: A Drug-Target Mendelian Randomization Study., PMID:40225015
Mechanistic insights into arimoclomol mediated effects on lysosomal function in Niemann-pick type C disease., PMID:40215728
TPCs: FROM PLANT TO HUMAN., PMID:40197126
Uncovering the Causal Link Between Obesity-Associated Genes and Multiple Sclerosis: A Systematic Literature Review., PMID:40195065
Small-molecule activation of TFEB alleviates Niemann-Pick disease type C via promoting lysosomal exocytosis and biogenesis., PMID:40184172
Development of a neutralization assay and bioluminescent imaging mouse model for Dehong virus (DEHV) using a pseudovirus system., PMID:40172216
Identification of a Novel NPC1L1 Inhibitor from Danshen and Its Role in Nonalcoholic Fatty Liver Disease., PMID:40141435
Triglyceride-lowering effect of rice protein due to the regulation of fatty acid uptake and transport of triglyceride in rats fed normal/oil-enriched diets., PMID:40135185
Development of a prognostic risk model for colorectal cancer and association of the prognostic model with cancer stem cell and immune cell infiltration., PMID:40115909
Intracellular anionic substances cause tau liquid-liquid phase separation., PMID:40107109
Cloning, phylogenetic analysis, tissue expression profiling, and functional roles of NPC1L1 in chickens, quails, and ducks., PMID:40106905
Elevated Cerebrospinal Fluid Total Tau in Niemann-Pick Disease Type C1: Correlation With Clinical Severity and Response to Therapeutic Interventions., PMID:40064165
Ezetimibe alters micelle structure and reduces Niemann-Pick C1-like 1-mediated absorption of vitamins E and K1 in CaCo-2 cells., PMID:40054527
Expression of the Niemann-Pick C1-like 1 Protein in Gastric Cancer., PMID:40037881
Detecting the Difficult: An Intronic NPC1 Variant Hiding in Plain Sight., PMID:40026274
Prevalence of Neutralizing Antibodies to AAV2 and AAV9 in Individuals with Niemann-Pick Disease, Type C1., PMID:40014475
Cholesin mRNA Expression in Human Intestinal, Liver, and Adipose Tissues., PMID:40004948
Distinct pathways for the absorption and metabolism of β-carotene and zeaxanthin in the mouse intestine., PMID:39971162
Microbiota-derived 3-Methyl-L-histidine mediates the proatherogenic effect of high chicken protein diet., PMID:39949981
Associations of Lipid-Lowering Drugs With Blood Pressure and Fasting Glucose: A Mendelian Randomization Study., PMID:39902581
Cryo-EM structure of Sudan ebolavirus glycoprotein complexed with its human endosomal receptor NPC1., PMID:39894818
Altered lipid homeostasis and autophagy precipitate diffuse alveolar hemorrhage in murine lupus., PMID:39871963
Dual targeting PPARα and NPC1L1 metabolic vulnerabilities blocks tumorigenesis., PMID:39862918
Ezetimibe Anticancer Activity via the p53/Mdm2 Pathway., PMID:39857778
Cholesterol mobilization regulates dendritic cell maturation and the immunogenic response to cancer., PMID:39838105
Decoding the blueprint of receptor binding by filoviruses through large-scale binding assays and machine learning., PMID:39818205
Clinical manifestations and molecular genetics of seven patients with Niemann-Pick type-C: a case series with a novel variant., PMID:39789920
The multiple facets of Rab proteins modulating the cellular distribution of cholesterol from the late endosomal compartment., PMID:39788156
NPC1 controls TGFBR1 stability in a cholesterol transport-independent manner and promotes hepatocellular carcinoma progression., PMID:39762312
Lipids, lipid-lowering drugs and the risk of herpes zoster: a Mendelian randomization study., PMID:39755897
An integrative approach to identifying NPC1 as a susceptibility gene for gestational diabetes mellitus., PMID:39746811
Multiple cell types support productive infection and dynamic translocation of infectious Ebola virus to the surface of human skin., PMID:39742475
Causal effects of circulating lipids and lipid-lowering drugs on the risk of atopic dermatitis: a mendelian randomization study., PMID:39718588
Dipyridamole Ameliorates Memory Impairment and Increases Hippocampal Calbindin Expression in Niemann Pick C1 Mice., PMID:39716810
NPC1 promotes the progression of hepatocellular carcinoma by mediating the accumulation of neutrophils into the tumor microenvironment., PMID:39707615
The inactivation of the Niemann Pick C1 cholesterol transporter restricts SARS-CoV-2 entry into host cells by decreasing ACE2 abundance at the plasma membrane., PMID:39707537
Instationary metabolic flux analysis reveals that NPC1 inhibition increases glycolysis and decreases mitochondrial metabolism in brain microvascular endothelial cells., PMID:39706535
Genetic correlation between genes targeted by lipid-lowering drugs and venous thromboembolism: A drug-target Mendelian randomization study., PMID:39705479
The Plasmodium falciparum NCR1 transporter is an antimalarial target that exports cholesterol from the parasite's plasma membrane., PMID:39693420
For research use only. Not for human or drug use.
