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Anti-Certolizumab Polyclonal Antibody

Catalog #:   PAB94405 Specific References (50) DATASHEET
Host species: Rabbit
Isotype: IgG
Applications: ELISA
Accession: CAS: 428863-50-7
Overview

Catalog No.

PAB94405

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

Certolizumab

Tested applications

ELISA: 1:4000-1:8000

Target

Certolizumab

Specificity

The product is specific for Certolizumab. This antibody serves as an excellent positive control for Certolizumab immunogenicity (ADA) assays.

Concentration

0.5 mg/ml

Purification

Purified by antigen affinity column.

Accession

CAS: 428863-50-7

Applications

ELISA

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Stability and Storage

The product can be stored for 2 - 3 weeks at 2 to 8°C or for up to 12 months at -20°C. Avoid repeated freezing and thawing cycles.

Background

Certolizumab is a Fab fragment of a monoclonal antibody to human tumor necrosis factor alpha (TNFα) which has potent antiinflammatory activity and is used in the therapy of severe rheumatoid arthritis and inflammatory bowel disease. Antibodysystem Anti-Certolizumab Antibody, pAb, Rabbit is produced from sera of a rabbit immunized with Certolizumab.

Data Image
References

Influence of Pharmacokinetic-Pharmacodynamic Failure Mechanisms on Outcomes in Biologic Therapy Sequencing in Inflammatory Bowel Disease: A Retrospective Cohort Study., PMID:40531271

Certolizumab pegol to prevent adverse pregnancy outcomes in patients with antiphospholipid syndrome and lupus anticoagulant (IMPACT): results of a prospective, single-arm, open-label, phase 2 trial., PMID:40483169

Glucocorticoid treatment in early rheumatoid arthritis is independently associated with increased PCSK9 levels: data from a randomised controlled trial., PMID:40480650

Pharmacogenomics of TNF inhibitors., PMID:40469293

Predicting Clinical Response to Monoclonal TNF Inhibitors in Rheumatoid Arthritis: A Transcriptomic Approach Based on Transmembrane TNF Reverse Signaling and Nrf2 Activation., PMID:40428231

Novel Small-Molecule Treatment and Emerging Biological Therapy for Psoriasis., PMID:40299379

Triple biologic therapy for refractory Crohn's disease., PMID:40251965

Discontinuation vs. continuation of concomitant methotrexate in patients with rheumatoid arthritis on certolizumab pegol: results from a randomised, controlled trial., PMID:40188084

Pharmacovigilance study and genetic target prediction analysis of FDA adverse event reports (FAERS) for drug-induced sinusitis., PMID:40128146

Certolizumab enhances spinal cord injury recovery in rats through inhibition of the TNF-α signaling pathway and neuronal apoptosis., PMID:40009347

Conducting a real-world study of Tumor Necrosis factor-alpha inhibitors-induced Systemic Lupus Erythematosus based on the FAERS database., PMID:40000785

Rheumatoid factors revisited in the age of biologic therapy., PMID:39982406

Risankizumab and Certolizumab Pegol Dual-Targeted Therapy for Crohn's Disease and Axial Spondyloarthritis: A Case Report., PMID:39981170

The use of aptamers as therapeutic inhibitors and biosensors of TNF-alpha., PMID:39971069

Management of Anal Fistula with Crohn's Disease., PMID:39882221

Pharmacovigilance Pregnancy Data in a Population of Japanese Patients With Chronic Inflammatory Disease Exposed to Certolizumab Pegol., PMID:39812078

What is rheumatoid factor? From screening to personalized management., PMID:39792161

Impaired coagulation parameters in early RA are restored by effective antirheumatic therapy: a prospective pilot study., PMID:39740931

Effectiveness and Treatment Persistence of Vedolizumab Compared to Anti-Tumour Necrosis Factor-α in Patients With Crohn's Disease: A Systematic Literature Review and Meta-Analysis., PMID:39707930

Comparative Study of Adalimumab, Infliximab and Certolizumab Pegol in the Treatment of Cystoid Macular Edema Due to Behçet's Disease., PMID:39685848

[Not Available]., PMID:39564635

Indirect comparison of deucravacitinib and other systemic treatments for moderate to severe plaque psoriasis in Asian populations: A systematic literature review and network meta-analysis., PMID:39526612

Influence of rheumatoid factor levels and TNF inhibitor structure on secondary nonresponse in rheumatoid arthritis patients., PMID:39296891

Comparison of established and preliminarily proposed ASAS MRI working group cut-offs for inflammatory MRI lesions in the sacroiliac joints in radiographic and non-radiographic axial spondyloarthritis., PMID:39231546

Impact of high rheumatoid factor levels on treatment outcomes with certolizumab pegol and adalimumab in patients with rheumatoid arthritis., PMID:39222436

Population PK modeling of certolizumab pegol in pregnant women with chronic inflammatory diseases., PMID:39219320

Exploratory analysis of the potential disconnect between objective inflammatory response and clinical response following certolizumab pegol treatment in patients with active axial spondyloarthritis., PMID:39209369

Certolizumab-induced sarcoidosis in a patient with psoriatic arthritis - a case report and review of literature., PMID:39180528

[Old and New Biologics and Small Molecules in Inflammatory Bowel Disease: Anti-Tumor Necrosis Factors]., PMID:39176459

Persistence of advanced systemic pharmacological treatment of moderate-to-severe psoriasis among bio-naïve patients-A retrospective register-based cohort study in Finland and Sweden., PMID:39092632

Association of rheumatoid factor, anti-citrullinated protein antibodies and shared epitope with clinical response to initial treatment in patients with early rheumatoid arthritis: data from a randomised controlled trial., PMID:39079894

Safety of TNF-α inhibitors: A real-world study based on the US FDA Adverse Event Reporting System Database., PMID:39029031

Certolizumab Has Favorable Efficacy on Preventing Pancreas and Target Organs Damage in Acute Pancreatitis., PMID:38986079

Retention rate of a novel autoinjector e-Device introduced to patients with chronic arthritis treated with certolizumab pegol in clinical practice: an observational implementation study., PMID:38975797

Added IMPACT: The first successful natural birth using certolizumab in obstetric APS., PMID:38970993

Targeting TNF-α: The therapeutic potential of certolizumab pegol in the early period of cerebral ischemia reperfusion injury in mice., PMID:38908079

Cardiovascular Adverse Events Associated with Tumor Necrosis Factor-Alpha Inhibitors: A Real-World Pharmacovigilance Analysis., PMID:38866553

Network meta-analysis: Comparative onset of early effect of biologics and small molecules in moderately to severely active luminal Crohn's disease., PMID:38863153

Ex vivo cell-based assay for assessment of response to TNF inhibitors in patients with rheumatic diseases., PMID:38796682

Evolving Landscape of Biologic Therapy for Pediatric Psoriasis., PMID:38796269

Biologics for Psoriasis., PMID:38796266

Treatment Discontinuation in Patients with Psoriasis Treated with Biologics: A Retrospective Analysis of German Health Claims Data., PMID:38787476

Acute peripartum pancreatitis complicating seronegative antiphospholipid antibody syndrome in pregnancy., PMID:38772869

Neurological disorders following the use of tumor necrosis factor-α inhibitors in inflammatory bowel disease patients: a real-world pharmacovigilance analysis., PMID:38769926

Certolizumab pegol effectiveness, survival and safety in patients with psoriasis: A multicenter retrospective analysis in daily clinical practice by the Spanish Psoriasis Group., PMID:38736107

Long-term clinical outcomes of certolizumab pegol treatment in non-radiographic axial spondyloarthritis stratified by baseline MRI and CRP status., PMID:38724259

Meta-analysis: Persistence of advanced therapies in the treatment of inflammatory bowel disease., PMID:38651771

Safety and effectiveness of certolizumab pegol in Japanese patients with rheumatoid arthritis: Up to 3-year results from a postmarketing surveillance study., PMID:38619380

Bartonella Henselae Related Unilateral Anterior Uveitis and Subsequent Multifocal Retinitis in a Case Under Certolizumab Treatment., PMID:38584900

Pharmacokinetics of Monoclonal Antibodies Throughout Pregnancy: A Systematic Literature Review., PMID:38583128

Datasheet
$ 354
Product specifications
50 μg 354 100 μg 680

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Anti-Certolizumab Polyclonal Antibody [PAB94405]
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