Catalog No.
YHJ51904
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Asp1025
Predicted molecular weight
118.62 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9BYX4
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
MDA-5, IFIH1, Helicard, Clinically amyopathic dermatomyositis autoantigen 140 kDa, Interferon-induced with helicase C domain protein 1, Helicase with 2 CARD domains, RNA helicase-DEAD box protein 116, RIG-I-like receptor 2, Interferon-induced helicase C domain-containing protein 1, MDA5, Murabutide down-regulated protein, Melanoma differentiation-associated protein 5, CADM-140 autoantigen, RH116, RLR-2,
Anti-melanoma differentiation-associated gene 5 antibody associated rapidly progressive interstitial lung disease in a pediatric patient: a case report., PMID:40514742
The macrophage-intrinsic MDA5-IRF5 axis drives HIV-1 intron-containing RNA-induced inflammatory responses., PMID:40493408
Tumor clusters with divergent inflammation and human retroelement expression determine the clinical outcome of patients with serous ovarian cancer., PMID:40492347
Getah virus nonstructural protein 2 suppresses interferon-beta production by interrupting interferon regulatory factor 3 activation., PMID:40483467
Defect in hematopoiesis and embryonic lethality at midgestation of Vps13a/Vps13c double knockout mice., PMID:40463036
MDA5 variants trade antiviral activity for protection from autoimmune disease., PMID:40457382
ATG5 negatively regulates grass carp reovirus-induced immune-inflammatory response by degrading RIG-I and MDA5., PMID:40454785
Potential of Circular RNAs (circRNAs) Neoantigen Vaccines in Tumor Immunotherapy., PMID:40442904
The Function of TRIM25 in Antiviral Defense and Viral Immune Evasion., PMID:40431746
Anti-MDA5 antibody positive dermatomyositis complicated by interstitial lung disease with an improved outcome: A case report., PMID:40419927
Palbociclib and dsRNA sensor co-operate to enhance anti-cancer effects through ER stress and modulation of immune evasion., PMID:40413207
The viral early protein 4 of human papillomavirus type 16 suppresses innate antiviral immunity., PMID:40409624
Identification of pattern recognition receptors participating in the innate immune response to Tembusu virus., PMID:40374862
Shared and Distinctive Inflammation-Related Protein Profiling in Idiopathic Inflammatory Myopathy with/without Anti-MDA5 Autoantibodies., PMID:40357378
cGAS/STING-Independent Induction of Type I Interferon by Inhibitors of the Histone Methylase KDM5B., PMID:40353728
The C-terminal nsP1a protein of porcine astrovirus antagonizes interferon beta production by targets MAVS and IRF3 signaling., PMID:40339257
Human papillomavirus E1 proteins inhibit RIG-I/MDA5-MAVS, TLR3-TRIF, cGAS-STING, and JAK-STAT signaling pathways to evade innate antiviral immunity., PMID:40330484
RBM39 shapes innate immunity by controlling the expression of key factors of the interferon response., PMID:40330464
Anti- Melanoma Differentiation-Associated Gene 5 Antibody Positive Dermatomyositis: Recent Progress in Pathophysiology and Treatment., PMID:40323493
CD19 CAR-T cell therapy in a pediatric patient with MDA5+ dermatomyositis and rapidly progressive interstitial lung disease., PMID:40306284
Accessory viral protein, V, of Newcastle Disease Virus binds dsRNA to facilitate immune evasion., PMID:40290766
Cepharanthine mitigates NIBV-induced pyroptosis via the MDA5/NF-κB/NLRP3 signaling pathway., PMID:40273551
Human papillomavirus E2 proteins suppress innate antiviral signaling pathways., PMID:40264759
Urolithin A alleviates radiation pneumonitis by activating PINK1/PRKN-mediated Mitophagy., PMID:40253768
SLIRP amplifies antiviral signaling via positive feedback regulation and contributes to autoimmune diseases., PMID:40253699
Generation of an induced pluripotent stem cell (iPSC) line (INNDSUi0010-A) from a patient with Anti-MDA5 antibody-positive dermatomyositis., PMID:40250126
Oxidation of human mitochondrial RNA strongly potentiates immunostimulation in an interferon-associated manner., PMID:40247667
Analysis of the immune response in COVID-19., PMID:40246347
Severe infection risk in triple and quadruple therapy for anti-MDA5 antibody-positive dermatomyositis., PMID:40244469
Identifying two pathways to poor prognosis in patients with anti-MDA5 antibodies: insights from prognostic factor and cytokines analysis., PMID:40241163
METTL3 depletion blocks vesicular stomatitis virus replication in pancreatic cancer cells through the establishment of an intrinsic antiviral state., PMID:40214229
Characterization of exoribonuclease XRN1 as a cancer target and identification of adenosine-3',5'-bisphosphate as a potent enzyme inhibitor., PMID:40205031
ADAR1 p150 prevents HSV-1 from triggering PKR/eIF2α-mediated translational arrest and is required for efficient viral replication., PMID:40198737
N6-methyladenosine modification of the subgroup J avian leukosis viral RNAs attenuates host innate immunity via MDA5 signaling., PMID:40198675
ATPase activity profiling of three human DExD/H-box RNA helicases., PMID:40194700
MDA5 ISGylation is crucial for immune signaling to control viral replication and pathogenesis., PMID:40184173
ASFV pS183L protein negatively regulates RLR-mediated antiviral signalling by blocking MDA5 oligomerisation., PMID:40165208
Interferon-Inducible ADAR1 p150 Is Essential for the Survival of Oral Squamous Cell Carcinoma., PMID:40135601
MDA5 protein mediating persistent ER stress/unfolded protein response contributes to endothelial-mesenchymal-transition of lung microvascular endothelial cell in dermatomyositis., PMID:40122798
LL37 complexed to double-stranded RNA induces RIG-I-like receptor signalling and Gasdermin E activation facilitating IL-36γ release from keratinocytes., PMID:40121229
Nailfold videocapillaroscopy findings are associated with IIM subtypes and IFN activation., PMID:40114239
Amyopathic dermatomyositis associated with immune checkpoint inhibitor therapy in lung adenocarcinoma: a case report., PMID:40104725
Overexpression of LMOD1 induces oxidative stress and enhances cell apoptosis of melanoma through the RIG-I like receptor pathway., PMID:40068386
External validation of the 2017 EULAR/ACR classification criteria for idiopathic inflammatory myopathies in anti-MDA5 antibody-positive interstitial lung disease patients: A multicenter retrospective cohort study in China., PMID:40056481
Plasma levels of adhesion molecules are elevated in dermatomyositis-interstitial lung disease and associated with low paraoxonase-1 activity., PMID:40055821
TRIM38 Inhibits Zika Virus by Upregulating RIG-I/MDA5 Pathway and Promoting Ubiquitin-Mediated Degradation of Viral NS3 Protein., PMID:40006954
Genome-wide profiling of N6-methyladenosine-modified pseudogene-derived long noncoding RNAs reveals the tumour-promoting and innate immune-restraining function of RPS15AP12 in ovarian cancer., PMID:40000433
The African swine fever virus gene MGF_360-4L inhibits interferon signaling by recruiting mitochondrial selective autophagy receptor SQSTM1 degrading MDA5 antagonizing innate immune responses., PMID:39998221
RNF20 dual regulation of MDA5 signaling to maintain immune homeostasis in chickens., PMID:39998124
RNF167 mediates atypical ubiquitylation and degradation of RLRs via two distinct proteolytic pathways., PMID:39994288
For research use only. Not for human or drug use.
