Catalog No.
YHK60801
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Lys653-Lys967
Predicted molecular weight
38.66 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9H2X9
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
KIAA1176, SLC12A5, Neuronal K-Cl cotransporter, KCC2, hKCC2, Solute carrier family 12 member 5, Electroneutral potassium-chloride cotransporter 2, K-Cl cotransporter 2
Biophysical characterization and ion transport with cell-based and proteoliposome reconstitution assays of invertebrate K+-Cl- cotransporters., PMID:40509965
An Evaluation of Cation-Chloride Cotransporters NKCC1 and KCC2 in Carbamazepine-Resistant Rats., PMID:40429905
Modulation of GABAergic System in a Chicken Retinal Ischemic Model: The Role of Chloride Cotransporters., PMID:40353346
Etomidate-Induced myoclonus in Sprague‒Dawley rats involves the activation of neocortical Calpain-2 and its decrement on KCC2 protein., PMID:40281446
Inefficient maturation of disease-linked mutant forms of the KCC2 potassium-chloride cotransporter correlates with predicted pathogenicity., PMID:40074080
Embryonic exposure to valproic acid and neonicotinoid deteriorates the hyperpolarizing GABA shift and impairs long-term potentiation of excitatory transmission in the local circuit of intermediate medial mesopallium of chick telencephalon., PMID:40037548
A "Knob Switch" Model for the Phosphoregulatory Mechanism of KCC3 at the Carboxy-Terminal Domain., PMID:40009635
Cerebellum KCC2 protein expression plasticity in response to cerebral cortical stroke., PMID:39909157
Exploring the molecular interface of gene expression dynamics and prostate cancer susceptibility in response to HBCD exposure., PMID:39906184
Maternal immune activation alters the GABAergic system in the prefrontal cortex of female rat offspring: Role of interleukin-6., PMID:39884421
Uncovering novel KCC2 regulatory motifs through a comprehensive transposon-based mutant library., PMID:39881966
Structural basis for human NKCC1 inhibition by loop diuretic drugs., PMID:39875725
VCP controls KCC2 degradation through FAF1 recruitment and accelerates emergence from anesthesia., PMID:39793039
Differential regulation of K+-Cl- cotransporter 2 (KCC2) and Na+-K+-Cl- cotransporter 1 (NKCC1) expression by zolpidem in CA1 and CA3 hippocampal subregions of the lithium-pilocarpine status epilepticus rat model., PMID:39779249
Protein Structural Modeling and Transport Thermodynamics Reveal That Plant Cation-Chloride Cotransporters Mediate Potassium-Chloride Symport., PMID:39684666
Identification of early Alzheimer's disease subclass and signature genes based on PANoptosis genes., PMID:39650656
A sustained-release gel alleviates neuropathic pain in SNI mice by reversing Glu/GABA imbalance and chloride efflux disorders., PMID:39647722
In vivo dynamic tracking of cerebral chloride regulation using molecularly tailored liquid/liquid interfacial ultramicro iontronics., PMID:39630900
Loss of the zinc receptor ZnR/GPR39 in mice enhances anxiety-related behavior and motor deficits, and modulates KCC2 expression in the amygdala., PMID:39581978
Restoring Compromised Cl- in D2 Neurons of a Huntington's Disease Mouse Model Rescues Motor Disability., PMID:39500579
Loss of PHF6 causes spontaneous seizures, enlarged brain ventricles and altered transcription in the cortex of a mouse model of the Börjeson-Forssman-Lehmann intellectual disability syndrome., PMID:39405291
ETV4‑mediated transcriptional activation of SLC12A5 exacerbates ferroptosis resistance and glucose metabolism reprogramming in breast cancer cells., PMID:39370816
VEGF, but Not BDNF, Prevents the Downregulation of KCC2 Induced by Axotomy in Extraocular Motoneurons., PMID:39337430
Combined use of CLP290 and bumetanide alleviates neuropathic pain and its mechanism after spinal cord injury in rats., PMID:39267289
Midbrain KCC2 downregulation: Implications for stress-related and substance use behaviors., PMID:39142020
Chloride deregulation and GABA depolarization in MTOR-related malformations of cortical development., PMID:39106285
Human-Induced Pluripotent Stem Cell (iPSC)-Derived GABAergic Neuron Differentiation in Bipolar Disorder., PMID:39056776
The P2X7 Hypothesis of Central Post-Stroke Pain., PMID:38928280
Hypothalamic-Pituitary-Adrenal Axis Dysfunction Elevates SUDEP Risk in a Sex-Specific Manner., PMID:38914464
Effect of Lipopolysaccharide on the Duration of Zolpidem-Induced Loss of Righting Reflex in Mice., PMID:38902210
Regulation of Neuronal Chloride Homeostasis by Pro- and Mature Brain-Derived Neurotrophic Factor (BDNF) via KCC2 Cation-Chloride Cotransporters in Rat Cortical Neurons., PMID:38892438
Unveiling the therapeutic potential of IHMT-337 in glioma treatment: targeting the EZH2-SLC12A5 axis., PMID:38886655
Isoflurane-induced neuroinflammation and NKCC1/KCC2 dysregulation result in long-term cognitive disorder in neonatal mice., PMID:38840092
Intraventricular haemorrhage in premature infants: the role of immature neuronal salt and water transport., PMID:38815055
GABAergic system and chloride cotransporters as potential therapeutic targets to mitigate cell death in ischemia., PMID:38808645
Reduced Gene Expression of KCC2 Accelerates Axonal Regeneration and Reduces Motor Dysfunctions after Tibial Nerve Severance and Suturing., PMID:38788828
Borax affects cellular viability by inducing ER stress in hepatocellular carcinoma cells by targeting SLC12A5., PMID:38780503
Tonic excitation by astrocytic GABA causes neuropathic pain by augmenting neuronal activity and glucose metabolism., PMID:38760512
Noise-induced hearing loss alters potassium-chloride cotransporter KCC2 and GABA inhibition in the auditory centers., PMID:38724641
NKCC1 in Neonatal Cochlear Support Cells Reloads Ions Necessary for Cochlear Spontaneous Activity., PMID:38724477
GABA transporter mGat4 is involved in multiple neural functions in mice., PMID:38697303
A potassium-chloride co-transporter with altered genome architecture functions as a suppressor in glioma., PMID:38685685
Evidence for Two Subpopulations of Cerebrospinal Fluid-Contacting Neurons with Opposite GABAergic Signaling in Adult Mouse Spinal Cord., PMID:38684364
The suppressive effect of the specific KCC2 modulator CLP290 on seizure in mice., PMID:38677001
A novel pathogenic SLC12A5 missense variant in epilepsy of infancy with migrating focal seizures causes impaired KCC2 chloride extrusion., PMID:38660387
[Screening for Characteristic Genes of Different Traditional Chinese Medicine Syndromes of Psoriasis Vulgaris: A Study Based on Bioinformatics and Machine Learning]., PMID:38645867
Identification and bioinformatics analysis of lncRNAs in serum of patients with ankylosing spondylitis., PMID:38622662
The expression system influences stability, maturation efficiency, and oligomeric properties of the potassium-chloride co-transporter KCC2., PMID:38373478
The mechanistic functional landscape of retinitis pigmentosa: a machine learning-driven approach to therapeutic target discovery., PMID:38321543
Suppression of HCN channels in the spinal dorsal horn restores KCC2 expression and attenuates diabetic neuropathic pain., PMID:38191090
For research use only. Not for human or drug use.
