Catalog No.
YHG61401
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Ala768
Predicted molecular weight
92.15 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q13618
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Cullin-3, KIAA0617, CUL-3, CUL3
Harnessing miRNA dynamics in HIV-1-infected macrophages: Unveiling new targeted therapeutics using systems biology., PMID:40453371
Dengue virus modulates critical cell cycle regulatory proteins in human megakaryocyte cells., PMID:40447783
Crosstalk between SUMOylation and ubiquitination controls the stability of transcription factor zinc finger protein 24: a novel antitumor mechanism in bladder cancer., PMID:40437183
Endoplasmic reticulum tubule junctions are sites of autophagy., PMID:40415242
Insights into the target-directed miRNA degradation mechanism in Drosophila ovarian cell culture., PMID:40328417
Modular-Based Synergetic Mechanisms of Jasminoidin and Ursodeoxycholic Acid in Cerebral Ischemia Therapy., PMID:40299522
Minding the synapse: A multi-omic approach reveals hidden regulators of neurodevelopment., PMID:40245839
The essential role of E3 ubiquitin ligases in the pathogenesis of neurodevelopmental and psychiatric disorders: Cul3, Cul4, Ube3a, and ZNRF1., PMID:40233431
Mechanistic Insights Into the Assembly of Functional CRL3 Dimeric Complexes., PMID:40211562
The tumor suppressor LZTR1: Its expression, purification and characterization., PMID:40204202
Discovery of a Novel CUL3 Variant: Unveiling Epilepsy and Newly Associated Dysmorphic Traits in a Turkish Patient., PMID:40176836
CSN-CRL Complexes: New Regulators of Adipogenesis., PMID:40149914
Staphylococcus aureus reprograms CASP8 (caspase 8) signaling to evade cell death and Xenophagy., PMID:40143428
The cross-talk between NRF2 and apoptosis in cancer., PMID:40126632
Enhanced memory despite severe sleep loss in Drosophila insomniac mutants., PMID:40111981
CBX3 promotes multidrug resistance by suppressing ferroptosis in colorectal carcinoma via the CUL3/NRF2/GPX2 axis., PMID:40089640
Activation, interaction and intimation of Nrf2 pathway and their mutational studies causing Nrf2 associated cancer., PMID:40088576
USP37 as a novel regulator of NRF2 protein stability and chemoresistance in HCC., PMID:40080254
Cullin 3 mitigates nonesterified fatty acid-induced oxidative stress in mammary epithelial cells: Involvement of BCL2/BECN1 and autophagy., PMID:40054686
Integrated multi-omic characterizations of the synapse reveal RNA processing factors and ubiquitin ligases associated with neurodevelopmental disorders., PMID:40054464
GCN5-related histone acetyltransferase HOOKLESS2 regulates fungal resistance and growth in tomato., PMID:40022479
Androgen receptor ubiquitination links KCTD13 to genitourinary tract defects., PMID:39968753
Biomarkers of Radioresistance in Head and Neck Cancer: A New Beginning., PMID:39964362
SPOP Suppresses Hepatocellular Carcinoma Growth and Metastasis by Ubiquitination and Proteasomal Degradation of TRAF6., PMID:39962908
UM171 glues asymmetric CRL3-HDAC1/2 assembly to degrade CoREST corepressors., PMID:39939761
Limiting cap-dependent translation increases 20S proteasomal degradation and protects the proteomic integrity in autophagy-deficient skeletal muscle., PMID:39878121
SPT5 regulates RNA polymerase II stability via Cullin 3-ARMC5 recognition., PMID:39854452
CUL4-Based Ubiquitin Ligases in Chromatin Regulation: An Evolutionary Perspective., PMID:39851492
The Cul3 ubiquitin ligase engages Insomniac as an adaptor to impact sleep and synaptic homeostasis., PMID:39841692
Camk2n1 deficiency reduces the NaCl cotransporter activity through the CUL3/KLHL3/WNK4 complex in the kidney., PMID:39798916
Study on mechanism of Spatholobi Caulis in the treatment of the hand-foot skin reaction induced by targeted drug therapy based on network pharmacology and molecular docking: An observational study., PMID:39792751
Cul3 substrate adaptor SPOP targets Nup153 for degradation., PMID:39785820
EHMT2-mediated R-loop formation promotes the malignant progression of prostate cancer via activating Aurora B., PMID:39763034
EGFR, TP53, and CUL3 Triple Mutation in Non-Small Cell Lung Cancer and its Potentially Poor Prognosis: A Case Report and Database Analysis., PMID:39727229
The Cullin3-Rbx1-KLHL9 E3 ubiquitin ligase complex ubiquitinates Rheb and supports amino acid-induced mTORC1 activation., PMID:39708321
Exploiting NRF2-ARE pathway activation in papillary renal cell carcinoma., PMID:39707614
Luteolin induces oxidative stress and apoptosis via dysregulating the cytoprotective Nrf2-Keap1-Cul3 redox signaling in metastatic castration-resistant prostate cancer cells., PMID:39699825
Familial Hyperkalemic Hypertension., PMID:39699086
Spop deficiency impairs adipogenesis and promotes thermogenic capacity in mice., PMID:39680603
Temporal and Spatial Characterization of CUL3KLHL20-driven Targeted Degradation of BET family, BRD Proteins by the Macrocycle-based Degrader BTR2004., PMID:39677683
Association between Locoregional Failure and NFE2L2/KEAP1/CUL3 Mutations in NRG/RTOG 9512: A Randomized Trial of Radiation Fractionation in T2N0 Glottic Cancer., PMID:39656603
CRL3ARMC5 ubiquitin ligase and Integrator phosphatase form parallel mechanisms to control early stages of RNA Pol II transcription., PMID:39667934
ZNF131-BACH1 transcriptionally accelerates RAD51-dependent homologous recombination repair and therapy-resistance of non-small-lung cancer cells by preventing their degradation from CUL3., PMID:39629137
Ubiquitin-Proteasome System in Periodontitis: Mechanisms and Clinical Implications., PMID:39626954
SPOP-mediated RIPK3 destabilization desensitizes LPS/sMAC/zVAD-induced necroptotic cell death., PMID:39540935
Redundant pathways for removal of defective RNA polymerase II complexes at a promoter-proximal pause checkpoint., PMID:39504960
CUL3-related neurodevelopmental disorder: Clinical phenotype of 20 new individuals and identification of a potential phenotype-associated episignature., PMID:39501558
ARMC5 selectively degrades SCAP-free SREBF1 and is essential for fatty acid desaturation in adipocytes., PMID:39491648
PRDX1 inhibits ferroptosis by binding to Cullin-3 as a molecular chaperone in colorectal cancer., PMID:39430237
Neddylation and Its Target Cullin 3 Are Essential for Adipocyte Differentiation., PMID:39404417
For research use only. Not for human or drug use.
