Anti-DLAT Polyclonal Antibody

Catalog No.

PHC81201

Species reactivity

Human, Mouse, Rat

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human DLAT (Gln374-Trp631).

Tested applications

ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000

Target

DLTA, M2 antigen complex 70 kDa subunit, 70 kDa mitochondrial autoantigen of primary biliary cirrhosis, Pyruvate dehydrogenase complex component E2, PDC-E2, DLAT, PBC, Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex, Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial, PDCE2

Purification

Purified by antigen affinity column.

Accession

P10515

Applications

ELISA, IHC, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Hypoxia inducible factor-1α drives cancer resistance to cuproptosis., PMID:40054467

Molecular mimicry-driven autoimmunity in chronic rhinosinusitis with nasal polyps., PMID:39984131

Autoantibodies Against Dihydrolipoamide S-Acetyltransferase Are Not Associated With Immune-Mediated Neuropathies., PMID:39556782

PEGylated Elesclomol@Cu(Ⅱ)-based Metal‒organic framework with effective nanozyme performance and cuproptosis induction efficacy for enhanced PD-L1-based immunotherapy., PMID:39554839

Cuproptosis-related genes predict prognosis and trastuzumab therapeutic response in HER2-positive breast cancer., PMID:38316885

Autoantibodies Against Dihydrolipoamide S-Acetyltransferase in Immune-Mediated Neuropathies., PMID:38181320

A Polymeric Hydrogel to Eliminate Programmed Death-Ligand 1 for Enhanced Tumor Radio-Immunotherapy., PMID:37988029

Glaucoma-Associated CDR1 Peptide Promotes RGC Survival in Retinal Explants through Molecular Interaction with Acidic Leucine Rich Nuclear Phosphoprotein 32A (ANP32A)., PMID:37509196

Curcumin Prevents the Glycation of Tricarboxylic Acid Cycle and Cell Respiration Proteins in the Heart of Mice Fed with a High-fructose Diet., PMID:35362381

E. coli and the etiology of human PBC: Antimitochondrial antibodies and spreading determinants., PMID:34608663

Cannabinoid Receptor 1 associates to different molecular complexes during GABAergic neuron maturation., PMID:33942314

Emerging views of mitophagy in immunity and autoimmune diseases., PMID:30951392

The HGF-MET axis coordinates liver cancer metabolism and autophagy for chemotherapeutic resistance., PMID:30786811

Deletion of Galectin-3 Enhances Xenobiotic Induced Murine Primary Biliary Cholangitis by Facilitating Apoptosis of BECs and Release of Autoantigens., PMID:26996208

Xenobiotics and loss of tolerance in primary biliary cholangitis., PMID:26755880

Making Sense of Autoantibodies in Cholestatic Liver Diseases., PMID:26593289

Analysis of Mycobacterial Protein Secretion., PMID:29675445

Innate immunity drives xenobiotic-induced murine autoimmune cholangitis., PMID:24547942

Escherichia coli infection induces autoimmune cholangitis and anti-mitochondrial antibodies in non-obese diabetic (NOD).B6 (Idd10/Idd18) mice., PMID:24128311

Antimitochondrial antibody heterogeneity and the xenobiotic etiology of primary biliary cirrhosis., PMID:23184636

The role of natural killer (NK) and NK T cells in the loss of tolerance in murine primary biliary cirrhosis., PMID:22519590

The multi-hit hypothesis of primary biliary cirrhosis: polyinosinic-polycytidylic acid (poly I:C) and murine autoimmune cholangitis., PMID:21910728

Electrophile-modified lipoic derivatives of PDC-E2 elicits anti-mitochondrial antibody reactivity., PMID:21763105

Mouse mammary tumor virus in anti-mitochondrial antibody producing mouse models., PMID:21334408

Apotopes and the biliary specificity of primary biliary cirrhosis., PMID:19185000

CD4 T-cell autoreactivity to the mitochondrial autoantigen PDC-E2 in AMA-negative primary biliary cirrhosis., PMID:18644699

Liver autoimmunity triggered by microbial activation of natural killer T cells., PMID:18474357

Ae2a,b-deficient mice develop antimitochondrial antibodies and other features resembling primary biliary cirrhosis., PMID:18471521

Autoimmune cholangitis in NOD.c3c4 mice is associated with cholangiocyte-specific Fas antigen deficiency., PMID:17482429

NOD.c3c4 congenic mice develop autoimmune biliary disease that serologically and pathogenetically models human primary biliary cirrhosis., PMID:16636131

PDC-E3BP is not a dominant T-cell autoantigen in primary biliary cirrhosis., PMID:16629643

Mycobacterium tuberculosis appears to lack alpha-ketoglutarate dehydrogenase and encodes pyruvate dehydrogenase in widely separated genes., PMID:16045627

Fate of immortalized human neuronal progenitor cells transplanted in rat spinal cord., PMID:15710850

[Analytic study of dot blotting for the detection of anti-Jo-1, anti-M2, anti-ribosomes and anti-LKM]., PMID:15297236

Self-association of class I major histocompatibility complex molecules in liposome and cell surface membranes., PMID:1322696

Clarification of the identity of the major M2 autoantigen in primary biliary cirrhosis., PMID:1851684

Identification of the platelet glycoprotein IIb/IIIa complex as a target antigen in primary biliary cirrhosis-associated autoimmune thrombocytopenia. Evidence that platelet-reactive autoantibodies can also bind to the mitochondrial antigen M2., PMID:2222752

Inhibition of enzyme function by human autoantibodies to an autoantigen pyruvate dehydrogenase E2: different epitope for spontaneous human and induced rabbit autoantibodies., PMID:1691062

Isolation of tryptic fragment of antigen from mitochondrial inner membrane proteins reacting with antimitochondrial antibody in sera of patients with primary biliary cirrhosis., PMID:2295468

Translational diffusion of class II major histocompatibility complex molecules is constrained by their cytoplasmic domains., PMID:2557353

[Autoantibodies in the diagnosis of autoimmune diseases of the liver]., PMID:2700108

Antimitochondrial antibodies in primary biliary cirrhosis recognize both specific peptides and shared epitopes of the M2 family of antigens., PMID:2474482

Identification and specificity of a cDNA encoding the 70 kd mitochondrial antigen recognized in primary biliary cirrhosis., PMID:3571977

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