Catalog No.
PHJ72201
Species reactivity
Human, Mouse, Rat
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human DNMT3B (Met1-Ser100).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
M.HsaIIIB, DNA (cytosine-5)-methyltransferase 3B, Dnmt3b, DNA methyltransferase HsaIIIB, DNA MTase HsaIIIB, DNMT3B
Purification
Purified by antigen affinity column.
Accession
Q9UBC3
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
The de novo DNA methyltransferase 3B is a novel epigenetic regulator of MYC in multiple myeloma, representing a promising therapeutic target to counter relapse., PMID:40241199
Combined Effect of Conventional Chemotherapy with Epigenetic Modulators on Glioblastoma., PMID:40004468
Exploring the intersection of epigenetics, DNA repair, and immunology from studies of ICF syndrome, an inborn error of immunity., PMID:38799442
Silencing of forkhead box C1 reduces nasal epithelial barrier damage in mice with allergic rhinitis via epigenetically upregulating secreted frizzled-related protein 5., PMID:38422887
Amino acids analysis reveals serum methionine contributes to diagnosis of the Kawasaki disease in mice and children., PMID:38008045
Enhanced CD19 activity in B cells contributes to immunodeficiency in mice deficient in the ICF syndrome gene Zbtb24., PMID:37990035
Epigenetic modifier alpha-ketoglutarate modulates aberrant gene body methylation and hydroxymethylation marks in diabetic heart., PMID:37101286
Characterization of a mouse model of ICF syndrome reveals enhanced CD19 activation in inducing hypogammaglobulinemia., PMID:36945532
Porcine Epidemic Diarrhea Virus nsp13 Protein Downregulates Neonatal Fc Receptor Expression by Causing Promoter Hypermethylation through the NF-κB Signaling Pathway., PMID:36602596
Autoimmunity in monogenic combined immune deficiencies with associated or syndromic features., PMID:36544766
[Mechanism of Mycobacterium tuberculosis on interleukin-6 receptor 3'-untranslated region methylation in CD4+T cells]., PMID:35381636
Huaier attenuates the adverse effects of pyroptosis by regulating the methylation of rat mesangial cells: an in vitro study., PMID:35351070
Global DNA methylation and increased DNMT3A expression in multiple myeloma patients., PMID:35173353
T Cell Repertoire Abnormality in Immunodeficiency Patients with DNA Repair and Methylation Defects., PMID:34825286
MALAT1 Promotes Tumorigenesis and Increases Cellular Sensitivity to Herceptin in HER2-positive Breast Cancer., PMID:34148540
Immunodeficiency, Centromeric Region Instability, and Facial Anomalies Syndrome (ICF) in a Boy with Variable Clinical and Immunological Presentations., PMID:33904683
Peripheral blood mononuclear cells are hypomethylated in active rheumatoid arthritis and methylation correlates with disease activity., PMID:33200208
Investigation of GSTP1 and epigenetic regulators expression pattern in a population of Iranian patients with prostate cancer., PMID:32831196
Melatonin-induced suppression of DNA methylation promotes odontogenic differentiation in human dental pulp cells., PMID:32718272
Clinical, Immunologic and Molecular Spectrum of Patients with Immunodeficiency, Centromeric Instability, and Facial Anomalies (ICF) Syndrome: A Systematic Review., PMID:32533820
Association analysis of DNA methyltransferases in IgA nephropathy., PMID:31931367
Epigenetics and prostate cancer: defining the timing of DNA methyltransferase deregulation during prostate cancer progression., PMID:31864524
Comprehensive bioinformatics study reveals targets and molecular mechanism of hesperetin in overcoming breast cancer chemoresistance., PMID:31659695
Regulation of DNA methylation levels in the process of oral mucosal regeneration in a rat oral ulcer model., PMID:31286466
Structural basis of specific DNA binding by the transcription factor ZBTB24., PMID:31226215
Blockade of TNFα to Improve Human CD34+ Cell Repopulating Activity in Allogeneic Stem Cell Transplantation., PMID:30723481
Effect of in ovo feeding of vitamin C on antioxidation and immune function of broiler chickens., PMID:30621801
Improved early development of porcine cloned embryos by treatment with quisinostat, a potent histone deacetylase inhibitor., PMID:30587665
Three Types of Immunodeficiency, Centromeric Instability, and Facial Anomalies (ICF) Syndrome Identified by Whole-Exome Sequencing in Saudi Hypogammaglobulinemia Patients: Clinical, Molecular, and Cytogenetic Features., PMID:30511102
Long noncoding RNA HOXB13-AS1 regulates HOXB13 gene methylation by interacting with EZH2 in glioma., PMID:30105866
B cell activation and plasma cell differentiation are inhibited by de novo DNA methylation., PMID:29765016
Expression of proteins upregulated in hepatocellular carcinoma in patients with alcoholic hepatitis (AH) compared to non-alcoholic steatohepatitis (NASH): An immunohistochemical analysis of candidate proteins., PMID:29425759
Iodine excess did not affect the global DNA methylation status and DNA methyltransferase expression in T and B lymphocytes from NOD.H-2h4 and Kunming mice., PMID:29253821
Expanding the mutation spectrum in ICF syndrome: Evidence for a gender bias in ICF2., PMID:28128455
Oct4 Methylation-Mediated Silencing As an Epigenetic Barrier Preventing Müller Glia Dedifferentiation in a Murine Model of Retinal Injury., PMID:27895551
Vesicourethral reflux-induced renal failure in a patient with ICF syndrome due to a novel DNMT3B mutation., PMID:27604394
Genetic, Cellular and Clinical Features of ICF Syndrome: a French National Survey., PMID:26851945
Epigenetic switch drives the conversion of fibroblasts into proinvasive cancer-associated fibroblasts., PMID:26667266
De novo DNA Methyltransferases Dnmt3a and Dnmt3b regulate the onset of Igκ light chain rearrangement during early B-cell development., PMID:26059604
A modular open platform for systematic functional studies under physiological conditions., PMID:26007658
DNA methyltransferase3a expression is an independent poor prognostic indicator in gastric cancer., PMID:25009393
Germline genes hypomethylation and expression define a molecular signature in peripheral blood of ICF patients: implications for diagnosis and etiology., PMID:24742017
Association of the DNMT3B -579G>T polymorphism with risk of thymomas in patients with myasthenia gravis., PMID:24260492
Upregulation of DNMT1 mediated by HBx suppresses RASSF1A expression independent of DNA methylation., PMID:24247422
AICAR sustains J1 mouse embryonic stem cell self-renewal and pluripotency by regulating transcription factor and epigenetic modulator expression., PMID:23988673
Hypomethylation and activation of syncytin-1 gene in endometriotic tissue., PMID:23888948
Development of an intracellular, DNA methyltransferase-specific, and gene-specific assay for studying dynamic DNA methylation., PMID:23888947
Heterogeneous clinical presentation in ICF syndrome: correlation with underlying gene defects., PMID:23486536
450K-array analysis of chronic lymphocytic leukemia cells reveals global DNA methylation to be relatively stable over time and similar in resting and proliferative compartments., PMID:22922567
Gene silencing of EREG mediated by DNA methylation and histone modification in human gastric cancers., PMID:22508389
For research use only. Not for human or drug use.
