Catalog No.
PHA95401
Species reactivity
Human
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human TLR5 (Ile21-Phe115).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
TIL3, TLR5, Toll/interleukin-1 receptor-like protein 3, Toll-like receptor 5
Purification
Purified by antigen affinity column.
Accession
O60602
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Exploration of the Pathogenicity and Inflammatory Mechanism of Wuxiang Virus: A Newly Identified Phlebovirus., PMID:40392072
Truncated flagellin lacking the hypervariable region: A structural basis for improved immune responses and adjuvanticity., PMID:40180103
TLR5 activation in respiratory epithelial cells orchestrate mucosal Th17 response through both indirect and direct pathways., PMID:40098159
Co-Delivery of Multiple Toll-Like Receptor Agonists and Avian Influenza Hemagglutinin on Protein Nanoparticles Enhances Vaccine Immunogenicity and Efficacy., PMID:39924738
Toll-like receptor upregulation in liver and peripheral blood mononuclear cells of patients with amoebic liver abscess., PMID:39919544
Structural engineering of flagellin as vaccine adjuvant: quest for the minimal domain of flagellin for TLR5 activation., PMID:39775323
Recombinant African swine fever virus p30-flagellin fusion protein promotes p30-specific humoral and cellular immune responses in mice., PMID:39671731
Differential Adjuvant Activity by Flagellins from Escherichia coli, Salmonella enterica Serotype Typhimurium, and Pseudomonas aeruginosa., PMID:39591115
Activated sympathetic nerve post stroke downregulates Toll-like receptor 5 and disrupts the gut mucosal barrier., PMID:39383869
Improving Vaccine Response through Probiotics and Micronutrient Supplementation: Evaluating the Role of TLR5 in Adult Female BALB/c Mice., PMID:39257145
Systemic antibody responses against gut microbiota flagellins implicate shared and divergent immune reactivity in Crohn's disease and chronic fatigue syndrome., PMID:39075559
mRNA vaccine design for Epstein-Barr virus: an immunoinformatic approach., PMID:39070665
Development of an anti-tauopathy mucosal vaccine specifically targeting pathologic conformers., PMID:38879560
Anti-carbamylated protein antibodies drive AEC II toward a profibrotic phenotype by interacting with carbamylated TLR5., PMID:38366924
Tlr5 deficiency exacerbates lupus-like disease in the MRL/lpr mouse model., PMID:38352866
Monocyte-derived transcriptomes explain the ineffectiveness of abatacept in rheumatoid arthritis., PMID:38167328
In silico designing and characterization of outer membrane protein K (OmpK) from Vibrio anguillarum and its expression in Nicotiana tabacum for the development of a plant-based vaccine against fish vibriosis., PMID:38151110
Therapeutic potential of Pseudomonas aeruginosa-mannose sensitive hemagglutinin (PA-MSHA) in cancer treatment., PMID:37871855
Protective antigen of Bacillus anthracis in combination with TLR4 or TLR5 agonist confers superior protection against lethal challenge in mouse model., PMID:37437686
Pathogenicity and innate immune responses induced by fowl adenovirus serotype 8b in specific pathogen-free chicken., PMID:37354616
Impact of Functional Polymorphisms on Drug Survival of Biological Therapies in Patients with Moderate-to-Severe Psoriasis., PMID:37240048
Intrinsic B cell TLR-BCR linked coengagement induces class-switched, hypermutated, neutralizing antibody responses in absence of T cells., PMID:37115935
Enhanced TLR5-dependent migration and activation of antigen-loaded airway dendritic cells by flagellin., PMID:36976041
Different immunological mechanisms between AQP4 antibody-positive and MOG antibody-positive optic neuritis based on RNA sequencing analysis of whole blood., PMID:36969199
MERS virus spike protein HTL-epitopes selection and multi-epitope vaccine design using computational biology., PMID:36935104
From Co-Infections to Autoimmune Disease via Hyperactivated Innate Immunity: COVID-19 Autoimmune Coagulopathies, Autoimmune Myocarditis and Multisystem Inflammatory Syndrome in Children., PMID:36769320
TLR5 agonists enhance anti-tumor immunity and overcome resistance to immune checkpoint therapy., PMID:36635337
Effects of Acute Cold Stress after Intermittent Cold Stimulation on Immune-Related Molecules, Intestinal Barrier Genes, and Heat Shock Proteins in Broiler Ileum., PMID:36496781
Short-chain fatty acids ameliorate necrotizing enterocolitis-like intestinal injury through enhancing Notch1-mediated single immunoglobulin interleukin-1-related receptor, toll-interacting protein, and A20 induction., PMID:36410023
Improving the ex vivo expansion of human tumor-reactive CD8 + T cells by targeting toll-like receptors., PMID:36394017
Flagellin Improves the Immune Response of an Infectious Bursal Disease Virus (IBDV) Subunit Vaccine., PMID:36366289
A Clinical Trial of Entolimod a TLR-5 Adjuvant for Vaccines Using Diphtheria or Tetanus as Carrier Proteins., PMID:36298456
Stimulation of naïve B cells with a fusion protein consisting of FlaA and Bet v 1 induces regulatory B cells ex vivo., PMID:36196479
Roseburia intestinalis stimulates TLR5-dependent intestinal immunity against Crohn's disease., PMID:36182776
A SARS-CoV-2 vaccine based on conjugation of SARS-CoV-2 RBD with IC28 peptide and mannan., PMID:36152702
Self-assembled flagella protein nanofibers induce enhanced mucosal immunity., PMID:36038418
Intestinal histopathology and immune responses following Escherichia coli lipopolysaccharide challenge in Nile tilapia fed enriched black soldier fly larval (BSF) meal supplemented with chitinase., PMID:36038101
Preparation and pre-clinical evaluation of flagellin-adjuvanted NOM vaccine candidate formulated with Spike protein against SARS-CoV-2 in mouse model., PMID:36030048
Different serotypes of Escherichia coli flagellin exert identical adjuvant effects., PMID:35953794
Optimal long peptide for flagellin-adjuvanted HPV E7 cancer vaccine to enhance tumor suppression in combination with anti-PD-1., PMID:35836530
Immunoinformatics Aided Design and In-Vivo Validation of a Cross-Reactive Peptide Based Multi-Epitope Vaccine Targeting Multiple Serotypes of Dengue Virus., PMID:35799781
Immune responses to Vibrio vulnificus formalin-killed vaccine and ghost vaccine in Scophthalmus maximus., PMID:35771999
The truncated form of flagellin (tFlic) provides the 2dCap subunit vaccine with better immunogenicity and protective effects in mice., PMID:35669451
Membrane orthologs of TLR5 of tongue sole Cynoglossus semilaevis: Expression patterns, signaling pathway and antibacterial property., PMID:35618170
Evaluation of the Whole Proteome of Achromobacter xylosoxidans to Identify Vaccine Targets for mRNA and Peptides-Based Vaccine Designing Against the Emerging Respiratory and Lung Cancer-Causing Bacteria., PMID:35186980
Yeast cell wall upregulated cell-mediated immune responses to Newcastle disease virus vaccine., PMID:35123352
Self-Assembly of Flagellin into Immunostimulatory Ring-like Nanostructures as an Antigen Delivery System., PMID:35080372
Activation of Toll-Like Receptors by Live Gram-Negative Bacterial Pathogens Reveals Mitigation of TLR4 Responses and Activation of TLR5 by Flagella., PMID:34888257
Recombinant Bacillus subtilis flagellin Hag is a potent immunostimulant with reduced proinflammatory properties compared to Salmonella enterica serovar Typhimurium FljB., PMID:34844822
Intermittent mild cold stimulation improves the immunity and cold resistance of spleens in broilers., PMID:34695632
For research use only. Not for human or drug use.
