Catalog No.
VHA94801
Species reactivity
Human
Host species
Human
Isotype
IgG4, kappa
Clonality
Monoclonal
Target
Cysteine knot superfamily 1, BMP antagonist 1, CKTSF1B1, Down-regulated in Mos-transformed cells protein, Increased in high glucose protein 2, IHG-2, DRM, GREM1, Gremlin-1, Cell proliferation-inducing gene 2 protein, DAN domain family member 2, DAND2
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
O60565
Applications
ELISA, FCM, Neutralization
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
Iv0131
Epithelial GREMLIN1 disrupts intestinal epithelial-mesenchymal crosstalk to induce a wnt-dependent ectopic stem cell niche through stromal remodelling., PMID:40467544
Over-expressed Phospholamban in Cancer-associated Fibroblasts Is a Driver for CMS4 Subtype Colorectal Cancer Formation., PMID:40288441
The Role of GREMLIN1, a Bone Morphogenetic Protein Antagonist, in Cancer Stem Cell Regulation., PMID:40277903
Evaluation of Gremlin-1 as a therapeutic target in metabolic dysfunction-associated steatohepatitis., PMID:39361025
Bone morphogenic protein-4 availability in the cardiac microenvironment controls inflammation and fibrosis in autoimmune myocarditis., PMID:39196111
Angiogenic and Fibrogenic Dual-effect of Gremlin1 on Proliferative Diabetic Retinopathy., PMID:38250154
Gremlin1 is a therapeutically targetable FGFR1 ligand that regulates lineage plasticity and castration resistance in prostate cancer., PMID:35624341
Epigenetic Modulation of Gremlin-1/NOTCH Pathway in Experimental Crescentic Immune-Mediated Glomerulonephritis., PMID:35215234
Protease-activated receptor-2 promotes osteogenesis in skeletal mesenchymal stem cells at the expense of adipogenesis: Involvement of interleukin-6., PMID:34430676
The Balance of Stromal BMP Signaling Mediated by GREM1 and ISLR Drives Colorectal Carcinogenesis., PMID:33197448
Antibody microarray analysis of amniotic fluid proteins associated with subsequent ruptured membranes in women with threatened preterm labor., PMID:33155323
Runs of Homozygosity in Modern Chicken Revealed by Sequence Data., PMID:33077478
Targeted Disruption of Bone Marrow Stromal Cell-Derived Gremlin1 Limits Multiple Myeloma Disease Progression In Vivo., PMID:32756430
Stage-specific regulation of Gremlin1 on the differentiation and expansion of human urinary induced pluripotent stem cells into endothelial progenitors., PMID:32468734
TGF-β pathway activation by idiopathic pulmonary fibrosis (IPF) fibroblast derived soluble factors is mediated by IL-6 trans-signaling., PMID:32070329
A panel of autoantibodies against tumor-associated antigens in the early immunodiagnosis of lung cancer., PMID:31980218
GREM1 is associated with metastasis and predicts poor prognosis in ER-negative breast cancer patients., PMID:31694641
Screening of tumor-associated antigens based on Oncomine database and evaluation of diagnostic value of autoantibodies in lung cancer., PMID:31629809
Gremlin, A Potential Urinary Biomarker of Anca-Associated Crescentic Glomerulonephritis., PMID:31053735
Excessive mechanical loading promotes osteoarthritis through the gremlin-1-NF-κB pathway., PMID:30926814
Inhibitory Antibodies against Activin A and TGF-β Reduce Self-Supported, but Not Soluble Factors-Induced Growth of Human Pulmonary Arterial Vascular Smooth Muscle Cells in Pulmonary Arterial Hypertension., PMID:30274147
Generation and Applications of a DNA Aptamer against Gremlin-1., PMID:28452949
GREM1 Is a Key Regulator of Synoviocyte Hyperplasia and Invasiveness., PMID:26834210
Gremlin promotes peritoneal membrane injury in an experimental mouse model and is associated with increased solute transport in peritoneal dialysis patients., PMID:25194662
Gremlin activates the Smad pathway linked to epithelial mesenchymal transdifferentiation in cultured tubular epithelial cells., PMID:24949470
Treatment with anti-gremlin 1 antibody ameliorates chronic hypoxia/SU5416-induced pulmonary arterial hypertension in mice., PMID:24160323
Sensing BMP pathway activity by immune detection of phosphorylated R-Smad proteins in mouse embryonic kidney., PMID:22639269
Co-expression of BMPs and BMP-inhibitors in human fractures and non-unions., PMID:22521262
Brain-derived neurotrophic factor is a regulator of human oocyte maturation and early embryo development., PMID:19463996
Angiopoietin-1 mediates the proangiogenic activity of the bone morphogenic protein antagonist Drm., PMID:18505784
Elevated levels of gremlin-1 in eutopic endometrium and peripheral serum in patients with endometriosis., PMID:18314105
The role of gremlin, a BMP antagonist, and epithelial-to-mesenchymal transition in proliferative vitreoretinopathy., PMID:17724219
Bone morphogenetic protein-4 inhibitor gremlin is overexpressed in idiopathic pulmonary fibrosis., PMID:16816361
In vitro induction of the pronephric duct in Xenopus explants., PMID:11940102
Identification of drm, a novel gene whose expression is suppressed in transformed cells and which can inhibit growth of normal but not transformed cells in culture., PMID:9234736
For research use only. Not for human or drug use.
