Cargo of small extracellular vesicles from neuronal origin shows progression of dementia in individuals with Down syndrome., PMID:40524460
Lecanemab Binds to Transgenic Mouse Model-Derived Amyloid-β Fibril Structures Resembling Alzheimer's Disease Type I, Type II and Arctic Folds., PMID:40495448
High precision and cost-effective multiplex quantification of amyloid-β40, amyloid-β42, p181Tau, p217Tau, neurofilament light chain, and glial fibrillary acidic protein from plasma and serum., PMID:40356374
An innovative electrochemiluminescent immunosensor using dual amplified signals from AuNPs@CoSn(OH)6 for the detection of the AD biomarker: amyloid beta 1-40., PMID:40326625
Amyloid-β-regulated gene circuits for programmable Alzheimer's disease therapy., PMID:40161792
Multianalyte Nanopore Detection of Alzheimer's Biomarkers: A Label-Free Platform with Improved Sensitivity and Range., PMID:40129019
Associations of Cerebrospinal Fluid Orexin-A, Alzheimer Disease Biomarkers, and Cognitive Performance., PMID:39957622
Biomarker treatment effects in two phase 3 trials of gantenerumab., PMID:39887500
Multi-Targeting Macrocyclic Peptides as Nanomolar Inhibitors of Self- and Cross-Seeded Amyloid Self-Assembly of α-Synuclein., PMID:39822034
Brain MRI volumetry and atrophy rating scales as predictors of amyloid status and eligibility for anti-amyloid treatment in a real-world memory clinic setting., PMID:39708177
Ultrasensitive Detection of Blood-Based Alzheimer's Disease Biomarkers: A Comprehensive SERS-Immunoassay Platform Enhanced by Machine Learning., PMID:39537190
Morphological and Molecular Profiling of Amyloid-β Species in Alzheimer's Pathogenesis., PMID:39446217
Performance of Plasma Biomarkers Combined with Structural MRI to Identify Candidate Participants for Alzheimer's Disease-Modifying Therapy., PMID:39350364
MEDI1814 selectively reduces free Aβ42 in cerebrospinal fluid of non-clinical species and Alzheimer's disease patients., PMID:39319998
Lecanemab demonstrates highly selective binding to Aβ protofibrils isolated from Alzheimer's disease brains., PMID:38906341
Quantitative systems pharmacology-based exploration of relevant anti-amyloid therapy challenges in clinical practice., PMID:38774587
Divergent Age-Dependent Conformational Rearrangement within Aβ Amyloid Deposits in APP23, APPPS1, and AppNL-F Mice., PMID:38652895
Comparison of cerebrospinal fluid, plasma and neuroimaging biomarker utility in Alzheimer's disease., PMID:38505230
The effect of human PBMCs immobilization on their Аβ42 aggregates-dependent proinflammatory state on a cellular model of Alzheimer's disease., PMID:38406587
Timing of Biomarker Changes in Sporadic Alzheimer's Disease in Estimated Years from Symptom Onset., PMID:38400792
Anti-CMV IgG Seropositivity is Associated with Plasma Biomarker Evidence of Amyloid-β Accumulation., PMID:38393897
Effect of hormone replacement therapy on amyloid beta (Aβ) plaque density in the rhesus macaque amygdala., PMID:38274989
Amyloid beta 42 alters cardiac metabolism and impairs cardiac function in male mice with obesity., PMID:38225272
Amyloid Modifier SERF1a Accelerates Alzheimer's Amyloid-β Fibrillization and Exacerbates the Cytotoxicity., PMID:38211979
Amyloid Beta Oligomers Activate Death Receptors and Mitochondria-Mediated Apoptotic Pathways in Cerebral Vascular Smooth Muscle Cells; Protective Effects of Carbonic Anhydrase Inhibitors., PMID:38132159
Serum immunoglobulins and biomarkers of dementia: a population-based study., PMID:37936180
Delivery of the Brainshuttle™ amyloid-beta antibody fusion trontinemab to non-human primate brain and projected efficacious dose regimens in humans., PMID:37823690
Amyloid fibril proteomics of AD brains reveals modifiers of aggregation and toxicity., PMID:37710351
CSF and plasma Aβ42/40 across Alzheimer's disease continuum: comparison of two ultrasensitive Simoa® assays targeting distinct amyloid regions., PMID:37656487
Distinct Molecular Signatures of Amyloid-Beta and Tau in Alzheimer's Disease Associated with Down Syndrome., PMID:37511361
Thimet oligopeptidase as a potential CSF biomarker for Alzheimer's disease: A cross-platform validation study., PMID:37502019
Inhibition of Amyloid β Aggregation and Cytotoxicity by Berbamine Hydrochloride., PMID:37470691
Neuroprotective Effects of IVIG against Alzheimer' s Disease via Regulation of Antigen Processing and Presentation by MHC Class I Molecules in 3xTg-AD Mice., PMID:37357300
Circulating antibodies to Helicobacter pylori are associated with biomarkers of neurodegeneration in cognitively intact adults., PMID:37352754
Clinical utility of an antibody-free LC-MS method to detect brain amyloid deposition in cognitively unimpaired individuals from the screening visit of the A4 Study., PMID:37274930
Improving the Accuracy, Robustness, and Dynamic Range of Digital Bead Assays., PMID:37229528
A combined physiologically-based pharmacokinetic and quantitative systems pharmacology model for modeling amyloid aggregation in Alzheimer's disease., PMID:36632701
Clinical performance of an antibody-free assay for plasma Aβ42/Aβ40 to detect early alterations of Alzheimer's disease in individuals with subjective cognitive decline., PMID:36604729
Herpes simplex virus alters Alzheimer's disease biomarkers - A hypothesis paper., PMID:36396609
Porphyromonas gingivalis Conditioned Medium Induces Amyloidogenic Processing of the Amyloid-β Protein Precursor upon in vitro Infection of SH-SY5Y Cells., PMID:36275415
Development of β-sheet structure in Aβ aggregation intermediates diminishes exposed hydrophobic surface area and enhances proinflammatory activity., PMID:35905824
Alzheimer's disease diagnosis based on detection of autoantibodies against Aβ using Aβ40 peptide in liposomes., PMID:35447142
Structural basis of Alzheimer β-amyloid peptide recognition by engineered lipocalin proteins with aggregation-blocking activity., PMID:35355502
Soluble TREM2 in CSF and its association with other biomarkers and cognition in autosomal-dominant Alzheimer's disease: a longitudinal observational study., PMID:35305339
Neuroprotective Effects of Probiotic-Supplemented Diet on Cognitive Behavior of 3xTg-AD Mice., PMID:35035837
Establishing pre-analytical requirements and maximizing peptide recovery in the analytical phase for mass spectrometric quantification of amyloid-β peptides 1-42 and 1-40 in CSF., PMID:34881836
Ultrasensitive capacitance sensor to detect amyloid-beta 1-40 in human serum using supramolecular recognition of β-CD/RGO/ITO micro-disk electrode., PMID:34736644
The Efficacy of High- or Low-Frequency Transcranial Magnetic Stimulation in Alzheimer's Disease Patients with Behavioral and Psychological Symptoms of Dementia., PMID:34716559
The global Alzheimer's Association round robin study on plasma amyloid β methods., PMID:34692980
Performance of the plasma Aβ42/Aβ40 ratio, measured with a novel HPLC-MS/MS method, as a biomarker of amyloid PET status in a DPUK-KOREAN cohort., PMID:34686209
For research use only. Not for human or drug use.
