Catalog No.
RHE55401
Expression system
Mammalian Cells
Species reactivity
Human
Host species
Alpaca
Isotype
VHH-8His-Cys-tag
Clonality
Monoclonal
Target
Intercrine reduced in hepatomas, hSDF-1, Stromal cell-derived factor 1, SDF-1, Pre-B cell growth-stimulating factor, SDF1, SDF1A, C-X-C motif chemokine 12, SDF1B, CXCL12, IRH, PBSF, hIRH
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Purified by Nickel column.
Accession
P48061
Applications
ELISA, RIA
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
SAA1273
Constitutive activity of an atypical chemokine receptor revealed by inverse agonistic nanobodies., PMID:39574661
Multivalent CXCR4-targeting nanobody formats differently affect affinity, receptor clustering, and antagonism., PMID:39098732
The nanobody targeting PD-L1 and CXCR4 counteracts pancreatic stellate cell-mediated tumour progression by disrupting tumour microenvironment., PMID:38581990
Molecular characterization of the CXCR4 / CXCR7 axis in germ cell tumors and its targetability using nanobody-drug-conjugates., PMID:37996954
Tumour inhibitory activity on pancreatic cancer by bispecific nanobody targeting PD-L1 and CXCR4., PMID:36284271
CXCR4-targeting nanobodies differentially inhibit CXCR4 function and HIV entry., PMID:30342024
Nanobody-Fc constructs targeting chemokine receptor CXCR4 potently inhibit signaling and CXCR4-mediated HIV-entry and induce antibody effector functions., PMID:30342023
CXCR4-Specific Nanobodies as Potential Therapeutics for WHIM syndrome., PMID:28768817
Llama-derived single variable domains (nanobodies) directed against chemokine receptor CXCR7 reduce head and neck cancer cell growth in vivo., PMID:23979133
Neutralizing nanobodies targeting diverse chemokines effectively inhibit chemokine function., PMID:23836909
Halting metastasis through CXCR4 inhibition., PMID:23211868
CXCR4 nanobodies (VHH-based single variable domains) potently inhibit chemotaxis and HIV-1 replication and mobilize stem cells., PMID:21059953
For research use only. Not for human or drug use.
