Anti-Human MMP12 Nanobody (SAA1293)

Catalog No.

RHE24701

Expression system

Mammalian Cells

Species reactivity

Human

Host species

Alpaca

Isotype

VHH-8His-Cys-tag

Clonality

Monoclonal

Target

Macrophage elastase, HME, ME, MMP12, Matrix metalloproteinase-12, MME, hME, MMP-12, Macrophage metalloelastase

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Purified by Nickel column.

Accession

P39900

Applications

ELISA

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Clone ID

SAA1293

CD131 antagonism blocks inflammation, emphysema and fibrosis in an asthma-COPD overlap mouse model originating in early life., PMID:39814691

IL-33/ST2 enhances MMP-12 expression by macrophages to mediate inflammatory and immune response in IgG4-Related Ophthalmic Disease., PMID:39299101

Airway proteomics reveals broad residual anti-inflammatory effects of prednisolone in mepolizumab-treated asthma., PMID:39097197

Tumor-Immune Signatures of Treatment Resistance to Brentuximab Vedotin with Ipilimumab and/or Nivolumab in Hodgkin Lymphoma., PMID:38934093

Multi-omics Analysis Reveals Immune Features Associated with Immunotherapy Benefit in Patients with Squamous Cell Lung Cancer from Phase III Lung-MAP S1400I Trial., PMID:38277235

Modulating asthma-COPD overlap responses with IL-17 inhibition., PMID:37965351

Apoptosis inhibitor of macrophage (AIM)/CD5L is involved in the pathogenesis of COPD., PMID:37592330

Topical emollient prevents the development of atopic dermatitis and atopic march in mice., PMID:37029953

Smoking status impacts treatment efficacy in smoke-induced lung inflammation: A pre-clinical study., PMID:36160400

Targeting the human βc receptor inhibits inflammatory myeloid cells and lung injury caused by acute cigarette smoke exposure., PMID:35599245

Autologous hematopoietic stem cell transplantation promotes connective tissue remodeling in systemic sclerosis patients., PMID:35488348

Targeted delivery of pentagalloyl glucose inhibits matrix metalloproteinase activity and preserves elastin in emphysematous lungs., PMID:34537081

Whole Genome Gene Expression: Histologic and Immunohistologic Study of Grafted Bone Using Allograft and Xenograft., PMID:33909719

Neutrophils and IL-1α Regulate Surfactant Homeostasis during Cigarette Smoking., PMID:33722877

Transforming growth factor-β1 inhibits interleukin-1β-induced expression of inflammatory genes and Cathepsin S activity in human vascular smooth muscle cells., PMID:33683760

Effect of anti-IL17 and/or Rho-kinase inhibitor treatments on vascular remodeling induced by chronic allergic pulmonary inflammation., PMID:33357114

Development and validation of a prognostic and immunotherapeutically relevant model in hepatocellular carcinoma., PMID:33241026

Tape-Strip Proteomic Profiling of Atopic Dermatitis on Dupilumab Identifies Minimally Invasive Biomarkers., PMID:32849633

Generation of highly selective monoclonal antibodies inhibiting a recalcitrant protease using decoy designs., PMID:32716053

Inflammation shapes pathogenesis of murine arrhythmogenic cardiomyopathy., PMID:32529556

Treatment with inhaled formulation of angiotensin-(1-7) reverses inflammation and pulmonary remodeling in a model of chronic asthma., PMID:32517880

Cigarette smoke-initiated autoimmunity facilitates sensitisation to elastin-induced COPD-like pathologies in mice., PMID:32366484

Cold-inducible RNA-binding protein contributes to tissue remodeling in chronic rhinosinusitis with nasal polyps., PMID:32198936

The Proteolytic Cleavage of Therapeutic Monoclonal Antibody Hinge Region: More Than a Matter of Subclass., PMID:32117299

Schwann Cell-Derived CCL2 Promotes the Perineural Invasion of Cervical Cancer., PMID:32064233

Targeting ST2 expressing activated regulatory T cells in Kras-mutant lung cancer., PMID:32002289

A panel of autoantibodies against tumor-associated antigens in the early immunodiagnosis of lung cancer., PMID:31980218

Characterization of the local wound environment following treatment of chronic leg ulcers with SIS wound matrix., PMID:31866230

Screening of tumor-associated antigens based on Oncomine database and evaluation of diagnostic value of autoantibodies in lung cancer., PMID:31629809

MMP2 Polymorphism Affects Plasma Matrix Metalloproteinase (MMP)-2 Levels, and Correlates with the Decline in Lung Function in Hypersensitivity Pneumonitis Positive to Autoantibodies Patients., PMID:31590404

Human basal cell carcinoma: the induction of anagen hair follicle differentiation., PMID:31556145

Matrix metalloproteinase-12 produced by Ly6Clow macrophages prolongs the survival after myocardial infarction by preventing neutrophil influx., PMID:31009606

Elastin-Specific Autoimmunity in Smokers With Thoracic Aortic Aneurysm and Dissection is Independent of Chronic Obstructive Pulmonary Disease., PMID:30957625

Blocking the IL-1β signalling pathway prevents chronic viral myocarditis and cardiac remodeling., PMID:30673858

Effect of Anti-IL17 Antibody Treatment Alone and in Combination With Rho-Kinase Inhibitor in a Murine Model of Asthma., PMID:30233389

The Matrix Metalloproteinases Panel in Multiple Sclerosis Patients Treated with Natalizumab: A Possible Answer to Natalizumab Non- Responders., PMID:29968546

Loss of Response to Anti-Tumor Necrosis Factor Alpha Therapy in Crohn's Disease Is Not Associated with Emergence of Novel Inflammatory Pathways., PMID:29372477

Inhibition of Fibroblast Activation Protein Restores a Balanced Extracellular Matrix and Reduces Fibrosis in Crohn's Disease Strictures Ex Vivo., PMID:29361086

Apelin: A putative novel predictive biomarker for bevacizumab response in colorectal cancer., PMID:28487489

Depletion of Neutrophils Promotes the Resolution of Pulmonary Inflammation and Fibrosis in Mice Infected with Paracoccidioides brasiliensis., PMID:27690127

Efficacy and safety of ustekinumab treatment in adults with moderate-to-severe atopic dermatitis., PMID:27304428

Enhanced protection from fibrosis and inflammation in the combined absence of IL-13 and IFN-γ., PMID:27125685

Proteolytic cleavage and loss of function of biologic agents that neutralize tumor necrosis factor in the mucosa of patients with inflammatory bowel disease., PMID:26170138

Identification of matrix metalloproteinase inhibitors by chemical arrays., PMID:25988721

MMP-12-mediated by SARM-TRIF signaling pathway contributes to IFN-γ-independent airway inflammation and AHR post RSV infection in nude mice., PMID:25652021

Macrophages from the synovium of active rheumatoid arthritis exhibit an activin A-dependent pro-inflammatory profile., PMID:25319955

Inhibition of elastase-pulmonary emphysema in dominant-negative MafB transgenic mice., PMID:25170302

Cigarette smoke-induced iBALT mediates macrophage activation in a B cell-dependent manner in COPD., PMID:25128521

Netrin-1 induces MMP-12-dependent E-cadherin degradation via the distinct activation of PKCα and FAK/Fyn in promoting mesenchymal stem cell motility., PMID:24738865

Lack of clinical manifestations in asymptomatic dengue infection is attributed to broad down-regulation and selective up-regulation of host defence response genes., PMID:24727912

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