Catalog No.
YHH38903
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
His603-Gln979
Predicted molecular weight
42.52 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q16849
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
ICA512-TMF, ICA512-CCF, Receptor-type tyrosine-protein phosphatase-like N, Islet cell autoantigen 3, ICA512, PTPRN, Islet cell antigen 512, ICA 512, PTP IA-2, ICA3, ICA512-NTF, R-PTP-N
Forsythoside B suppresses glioblastoma by upregulating the expression of PTPRN., PMID:40383262
DNA methylation profiles for breast cancer subtype classifications: A translational study from microarray to methylation-specific PCR (MSP)., PMID:40352186
Broad Target Screening Reveals Abundance of FKBP12-Based Molecular Glues in Focused Libraries., PMID:40336336
What is known and unknown about the role of neuroendocrine genes Ptprn and Ptprn2., PMID:39926347
Construction and validation of a prognostic model based on oxidative stress-related genes in non-small cell lung cancer (NSCLC): predicting patient outcomes and therapy responses., PMID:39669999
General population screening for type 1 diabetes using islet autoantibodies at the preschool vaccination visit: a proof-of-concept study (the T1Early study)., PMID:38925883
Protein Tyrosine Phosphatase Receptors N and N2 Control Pituitary Melanotroph Development and POMC Expression., PMID:38923438
A Novel Ubiquitin Ligase Adaptor PTPRN Suppresses Seizure Susceptibility through Endocytosis of NaV1.2 Sodium Channels., PMID:38874331
Identification of Prognostic Markers of Glioblastoma through Bioinformatics Analysis., PMID:38639614
TBK1, a prioritized drug repurposing target for amyotrophic lateral sclerosis: evidence from druggable genome Mendelian randomization and pharmacological verification in vitro., PMID:38443977
Development of an ostrich-derived single-chain variable fragment (scFv) against PTPRN extracellular domain., PMID:38355744
Exploring the mechanism of Celastrol in the treatment of rheumatoid arthritis based on systems pharmacology and multi-omics., PMID:38238321
Condensation of the β-cell secretory granule luminal cargoes pro/insulin and ICA512 RESP18 homology domain., PMID:37159024
Construction and validation of a cuproptosis-related prognostic model for glioblastoma., PMID:36814929
Common and female-specific roles of protein tyrosine phosphatase receptors N and N2 in mice reproduction., PMID:36611058
Non-HLA Antibodies and Their Role in Highly Sensitized Patients., PMID:36319497
Regulation Networks of Non-Coding RNA-Associated ceRNAs in Cisplatin-Induced Acute Kidney Injury., PMID:36230932
Exploration of the underlying biological differences and targets in ovarian cancer patients with diverse immunotherapy response., PMID:36189254
Genome-wide meta-analysis and omics integration identifies novel genes associated with diabetic kidney disease., PMID:35763030
PTPRN Serves as a Prognostic Biomarker and Correlated with Immune Infiltrates in Low Grade Glioma., PMID:35741647
Prognostic significance of AP-2α/γ targets as cancer therapeutics., PMID:35361846
Identification of Key Genes Associated with Brain Metastasis from Breast Cancer: A Bioinformatics Analysis., PMID:35296631
Glutamic Acid Decarboxylase and Tyrosine Phosphatase-Related Islet Antigen-2 Positivity among Children and Adolescents with Diabetes in Korea., PMID:35263538
Seroreactivity Against Tyrosine Phosphatase PTPRN Links Type 2 Diabetes and Colorectal Cancer and Identifies a Potential Diagnostic and Therapeutic Target., PMID:35040477
Knockdown of Ptprn-2 delays the onset of puberty in female rats., PMID:34607132
Genetic variation at ERBB3/IKZF4 and sexual dimorphism in epitope spreading in single autoantibody-positive relatives., PMID:34448034
Simplifying prediction of disease progression in pre-symptomatic type 1 diabetes using a single blood sample., PMID:34338806
Characteristics of children diagnosed with type 1 diabetes before vs after 6 years of age in the TEDDY cohort study., PMID:34291312
Overexpression of PTPRN Promotes Metastasis of Lung Adenocarcinoma and Suppresses NK Cell Cytotoxicity., PMID:34150744
The oxylipin profile is associated with development of type 1 diabetes: the Diabetes Autoimmunity Study in the Young (DAISY)., PMID:33893822
Total Platelet Transcriptomics and Its Network Analysis by RNA-Seq and miRNA-Seq and PCA Application in Essential Thrombocythaemia., PMID:33227791
Diagnostic value of combined islet antigen-reactive T cells and autoantibodies assays for type 1 diabetes mellitus., PMID:33064907
Different interaction of onset age and duration of type 1 diabetes on the dynamics of autoantibodies to insulinoma-associated antigen-2 and zinc transporter 8., PMID:32696593
Molecular docking and machine learning analysis of Abemaciclib in colon cancer., PMID:32640984
HLA-DR-DQ haplotypes and specificity of the initial autoantibody in islet specific autoimmunity., PMID:32613719
Why is the presence of autoantibodies against GAD associated with a relatively slow progression to clinical diabetes?, PMID:32451571
Regulated Endocrine-Specific Protein-18, an Emerging Endocrine Protein in Physiology: A Literature Review., PMID:31294787
Type 1 diabetes genetic risk score discriminates between monogenic and Type 1 diabetes in children diagnosed at the age of <5 years in the Iranian population., PMID:31276222
Autoantibodies Directed Toward a Novel IA-2 Variant Protein Enhance Prediction of Type 1 Diabetes., PMID:31167877
Detecting autoreactive B cells in the peripheral blood of people with type 1 diabetes using ELISpot., PMID:31152768
ICA512 RESP18 homology domain is a protein-condensing factor and insulin fibrillation inhibitor., PMID:30979722
Identification of a Simple and Novel Cut-Point Based Cerebrospinal Fluid and MRI Signature for Predicting Alzheimer's Disease Progression that Reinforces the 2018 NIA-AA Research Framework., PMID:30775985
Rotavirus Infection Enhances Levels of Autoantibodies Against Islet Cell Antigens GAD65 and IA-2 in Children with Type 1 Diabetes., PMID:30588857
Identification of glioblastoma gene prognosis modules based on weighted gene co-expression network analysis., PMID:30382873
Autoantibodies against ZnT8 are rare in Central-European LADA patients and absent in MODY patients, including those positive for other autoantibodies., PMID:30377089
Autoantibodies to the IA-2 Extracellular Domain Refine the Definition of "A+" Subtypes of Ketosis-Prone Diabetes., PMID:30327357
CTLA-4 +49 G/A, a functional T1D risk SNP, affects CTLA-4 level in Treg subsets and IA-2A positivity, but not beta-cell function., PMID:29973665
Autoimmunity-Associated PTPN22 Polymorphisms in Latent Autoimmune Diabetes of the Adult Differ from Those of Type 1 Diabetes Patients., PMID:29895027
Prognostic Value of Phosphotyrosine Phosphatases in Hepatocellular Carcinoma., PMID:29742497
Current Challenges and Opportunities in Treating Glioblastoma., PMID:29669750
For research use only. Not for human or drug use.
