Catalog No.
EHF90701
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
Gln30-Tyr406
Predicted molecular weight
45.67 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q01973
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Neurotrophic tyrosine kinase, receptor-related 1, Inactive tyrosine-protein kinase transmembrane receptor ROR1, NTRKR1, ROR1
Quantification of Wnt3a, Wnt5a and Wnt16 Binding to Multiple Frizzleds Under Physiological Conditions Using NanoBit/BRET., PMID:40497984
Optimization of 1-Methyl-3-(pyridin-3-yl)-1H-indol Derivatives as ROR1 Inhibitors with Improved Activity and Selectivity., PMID:40456695
Uncovering a Novel Role of ROR1 in the Epigenetic Regulation of Tumor Suppressor Gene CREB3L1 in Triple-Negative Breast Cancer Cells., PMID:40427627
Structure-directing optimization of N-(2,3-dihydrobenzo[b] [1,4]dioxin-6-yl)benzamide derivatives as selective receptor tyrosine kinase-like orphan receptor 1 (ROR1) inhibitors for cancer therapy., PMID:40409056
Endoplasmic reticulum stress disrupts signaling via altered processing of transmembrane receptors., PMID:40307870
Wnt5a induces ROR1 dependent NF-κB activation to enhance MMP-9 expression and invasiveness in chronic lymphocytic leukemia., PMID:40295829
Novel macromolecule CPD4 suppresses cell proliferation and metastasis of triple-negative breast cancer by targeting ROR1 protein., PMID:40274160
Non-canonical Wnt co-receptors ROR1/ROR2 are differentially regulated by hypoxia in colon cancer cells., PMID:40268059
Short-Chain Fatty Acids Modulate Anti-ROR1 CAR T-Cell Function and Exhaustion in an Intestinal Adenocarcinoma-on-Chip Model., PMID:40249196
A ROR1 targeted bispecific T cell engager shows high potency in the pre-clinical model of triple negative breast cancer., PMID:40165319
Unveiling circulating targets in pancreatic cancer: Insights from proteogenomic evidence and clinical cohorts., PMID:40060891
Downregulation of RORl via STAT3 and P300 Promotes P38 Pathway- Dependent Lens Epithelial Cells Apoptosis in Age-Related Cataract., PMID:40019609
Mediating Mendelian randomization in the proteome identified potential drug targets for obesity-related allergic asthma., PMID:39893495
Discovery of the first potent ROR1 degrader for the treatment of non-small cell lung cancer., PMID:39889450
A novel ROR1-targeting antibody-PROTAC conjugate promotes BRD4 degradation for solid tumor treatment., PMID:39816690
Genome-wide association neural networks identify genes linked to family history of Alzheimer's disease., PMID:39775791
The Multi-Kinase Inhibitor GZD824 (Olverembatinib) Shows Pre-Clinical Efficacy in Endometrial Cancer., PMID:39739675
Insights into genetic aberrations and signalling pathway interactions in chronic lymphocytic leukemia: from pathogenesis to treatment strategies., PMID:39732734
A prodrug nanodevice co-delivering docetaxel and ROR1 siRNA for enhanced triple negative breast cancer therapy., PMID:39730101
Identification of a novel anti-ROR1 nanobody through phage display and its biochemical characterization., PMID:39645564
RORing CAR T Cells in Solid and Hematologic Cancers: Same but Different., PMID:39625823
Discovery of 3-(2-aminobenzo[d]thiazol-5-yl) benzamide derivatives as potent anticancer agents via ROR1 inhibition., PMID:39591876
Twofold Expression of Receptor Tyrosine Kinase 2 (ROR2) in Giant Cell Tumors of Bone: Outcome of a Case‒Control Study., PMID:39555360
Highly specific detection of ROR1 cancer biomarker with bipolar electrochemiluminescence., PMID:39514011
Tumour assessment of ROR1 levels in various adult leukaemia and lymphoma types., PMID:39495778
Phase I Study of ROR1-Specific CAR-T Cells in Advanced Hematopoietic and Epithelial Malignancies., PMID:39466024
ROR1 facilitates glioblastoma growth via stabilizing GRB2 to promote c-Fos expression in glioma stem cells., PMID:39447031
A Sequential Population Pharmacokinetic Model of Zilovertamab Vedotin in Patients with Hematologic Malignancies Extrapolated to the Pediatric Population., PMID:39438409
Wnt family members regulating osteogenesis and their origins., PMID:39283365
Engineering potent chimeric antigen receptor T cells by programming signaling during T-cell activation., PMID:39266656
PRL1 interacts with and stabilizes RPA2A to regulate carbon deprivation-induced senescence in Arabidopsis., PMID:39229867
Unlocking the potential: advancements and future horizons in ROR1-targeted cancer therapies., PMID:39145866
Novel humanized monoclonal antibodies against ROR1 for cancer therapy., PMID:39138527
[Screening and validation of therapeutic targets for chronic sinusitis with nasal polyps based on proteomics]., PMID:39107122
Polyoxygenated cembrane-type diterpenes from the Hainan soft coral Lobophytum crassum as a promising source of anticancer agents with ErbB3 and ROR1 inhibitory potential., PMID:39075227
Variant Transcript of ROR1 ENST00000545203 Does Not Encode ROR1 Protein., PMID:39062146
Pentagalloyl Glucose (PGG) Exhibits Anti-Cancer Activity against Aggressive Prostate Cancer by Modulating the ROR1 Mediated AKT-GSK3β Pathway., PMID:39000112
Receptor tyrosine kinase-like orphan receptor serves as a potential target in cancer immunotherapy., PMID:38973261
How receptor tyrosine kinase-like orphan receptor 1 meets its partners in chronic lymphocytic leukemia., PMID:38949887
Development of Peptide Paratope Mimics Derived from the Anti-ROR1 Antibody and Long-Acting Peptide-Drug Conjugates for Targeted Cancer Therapy., PMID:38943600
Discovery of Novel Receptor Tyrosine Kinase-like Orphan Receptor 1 (ROR1) Inhibitors for Cancer Treatment., PMID:38913699
Characterization of Wnt Signaling Pathway Aberrations in Metastatic Prostate Cancer., PMID:38912907
Astrocytes-Secreted WNT5B Disrupts the Blood-Brain Barrier Via ROR1/JNK/c-JUN Cascade During Meningitic Escherichia Coli Infection., PMID:38896157
ROR1-AS1: A Meaningful Long Noncoding RNA in Oncogenesis., PMID:38859780
Exosomal ROR1 in peritoneal fluid identifies peritoneal disseminated PDAC and is associated with poor survival., PMID:38846943
Heterogeneous Profile of ROR1 Protein Expression across Tumor Types., PMID:38791952
Exosomal lncRNA ROR1-AS1 from cancer-associated fibroblasts inhibits ferroptosis of lung cancer cells through the IGF2BP1/SLC7A11 signal axis., PMID:38729321
WNT5B drives osteosarcoma stemness, chemoresistance and metastasis., PMID:38689429
Dihydroartemisinin inhibits tumor progress via blocking ROR1-induced STAT3-activation in non-small cell lung cancer., PMID:38678671
Armored TGFβRIIDN ROR1-CAR T cells reject solid tumors and resist suppression by constitutively-expressed and treatment-induced TGFβ1., PMID:38609317
For research use only. Not for human or drug use.
